Background: In comparison to other arterial and venous conduits, the left internal mammary artery (LIMA) conduit showed superior graft patency and outstanding excellent long-term clinical outcomes. In situ LIMA grafting to the left anterior descending artery (LAD) is believed to be the "gold standard" of coronary revascularization for decades. Objective: We aimed to compare between two surgical methods for grafting diffusely diseased LAD. Patients and Methods: This retrospective clinical trial was carried out on 80 adult cases with diffuse LAD disease in addition to right coronary artery and left circumflex artery involvement or their branches. They were scheduled for coronary artery bypass grafting (CABG) using the cardiopulmonary bypass in Cardiac