Long-read sequencing reveals novel isoform-specific eQTLs and regulatory mechanisms of isoform expression
Yuya Nagura,
Mihoko Shimada,
Ryoji Kuribayashi
et al.
Abstract:Genetic variations linked to changes in gene expression are known as expression quantitative loci (eQTLs). The identification of eQTLs provides a profound understanding of the mechanisms governing gene expression. However, prior studies have primarily utilized short-read sequencing techniques, and the analysis of eQTLs on isoforms has been relatively limited. In this study, we employed long-read sequencing technology (Oxford Nanopore) on B cells from 67 healthy Japanese individuals to explore genetic variation… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.