Long‐Range Electron Transfer in Peptides and Proteins

Isied, Stephan S.

doi:10.1002/9780470166338.ch5

Cited by 54 publications

(3 citation statements)

References 159 publications

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“…SSA24Fc was synthesized differently due to its poor solubility in 4 N HCl dioxane solution. Boc-(Ala-Aib) 4 -OBzl was modified with DL-α-lipoic acid after similar deprotection of the Boc group, and then the OBzl group was removed by treatment with a 1 N NaOH aqueous solution in methanol and dioxane. This fragment was coupled to the N -terminal of the 16mer having the ferrocene moiety at the C-terminal, which was the intermediate for synthesis of SSA16Fc by HATU and DIEA to afford SSA24Fc.…”

Section: Synthesis Of Helical Peptidesmentioning

confidence: 99%

“…Boc-(Ala-Aib) 4 -OBzl and Boc-(Ala-Aib) 8 -OBzl were synthesized according to the method reported in the literature [24] where Boc stands for tertbutyloxycarbonyl and OBzl for benzyl ester. Chemical modifications of the peptides (8mer and 16mer) with the ferrocene moiety at the C-terminal and lipoic acid at the N -terminal were done similar to our previous work [10].…”

Section: Synthesis Of Helical Peptidesmentioning

confidence: 99%

“…Electron transfer though peptide secondary structures has been of great interest for clarifying efficient electron-transfer reactions occurring in protein assemblies in nature [1][2][3][4][5]. Especially, electron transfer through helices has attracted much attention because it is believed that α-helical segments play an essential role in mediating an electron and determining its direction in biological systems [6].…”

Section: Introductionmentioning

confidence: 99%

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Distance dependence of long‐range electron transfer through helical peptides

Kai

Takeda

Morita

et al. 2007

Journal of Peptide Science

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Helical peptides of 8mer, 16mer, and 24mer carrying a disulfide group at the N -terminal and a ferrocene moiety at the C-terminal were synthesized, and they were self-assembled on gold by a sulfur-gold linkage. Infrared reflection-absorption spectroscopy and ellipsometry confirmed that they formed a monolayer with upright orientation. Cyclic voltammetry showed that the electron transfer from the ferrocene moiety to gold occurred even with the longest 24mer peptide. Chronoamperometry and electrochemical impedance spectroscopy were carried out to determine the standard electron transfer rate constants. It was found that the dependence of the electron-transfer rates on the distance was significantly weak with the extension of the chain from 16mer to 24mer (decay constant β = 0.02-0.04). This dependence on distance cannot be explained by an electron tunneling mechanism even if increased hydrogen-bonding cooperativity or molecular dynamics is considered. It is thus concluded that this long-range electron transfer is operated by an electron hopping mechanism.

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Section: Synthesis Of Helical Peptidesmentioning

confidence: 99%

Section: Synthesis Of Helical Peptidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Distance dependence of long‐range electron transfer through helical peptides

Kai

Takeda

Morita

et al. 2007

Journal of Peptide Science

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Mediated Electron‐transfer between Redox‐enzymes and Electrode Supports

Katz¹,

Shipway²,

Willner³

2002

Encyclopedia of Electrochemistry

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The sections in this article are Introduction Electron‐transfer Provided by Diffusional Mediators Dissolved Enzymes Activated by Diffusional Mediators Monolayer‐ or Multilayer‐enzyme Electrodes Activated by Diffusional Mediators Polymer‐ or Inorganic Matrix‐immobilized Enzymes Activated by Diffusional Mediators The Electrical Contacting of Dissolved Enzymes at Mediator‐Functionalized Electrodes Chiroselective Electron‐transfer‐mediated Biotransformations Chiral Diffusional Electron‐transfer Mediators Chiral Monolayer‐immobilized Electron‐transfer Mediators The Electrical Contacting of Mediator‐modified Enzymes Dissolved Redox Enzymes Functionalized with Electron‐transfer Mediators Monolayer‐ and Multilayer‐enzyme Assemblies Functionalized with Electron‐transfer Mediators Polymer‐ and Inorganic Matrix‐bound Enzymes Contacted by Coimmobilized Mediators The Electrical Contacting of Enzymes in Mediator‐functionalized Polymers The Electrical Contacting of Enzymes in Mediator‐functionalized Sol–gel Matrices The Electrical Contacting of Enzymes in Mediator‐containing Graphite Paste Composites The Electrical Contacting of FAD ‐enzymes by Mediator‐functionalized FAD Electrical Contacting of Enzymes by Reconstitution of Apo‐flavoenzymes with Relay‐ FAD Cofactor Units Electrical Contacting of Enzymes by Surface‐reconstitution of Apo‐flavoenzymes on Relay‐ FAD ‐functionalized Electrodes The Electrical Contacting of NAD ( P ) + ‐dependent Enzymes The Electrochemical Regeneration of NAD ( P ) + ‐cofactors The Electrochemical Regeneration of NAD ( P ) H ‐cofactors The Association of NAD ( P ) + ‐dependent Enzymes with NAD ( P ) + Cofactors by Covalent and Entrapment Methods The Integration of NAD ( P ) + ‐dependent Enzymes with Monolayer Arrays of NAD + ‐cofactor and Redox‐catalysts Electrical Contacting by Interprotein Electron‐transfer Soluble Cytochromes as Electron‐transfer Mediators Heme‐protein Monolayers as Electron‐transfer Mediators Microperoxidase‐11 Monolayers Heme‐containing D e n ovo Protein Monolayers Cyt c ‐aligned Monolayers Associated with Cytochrome Oxidase Applications of Enzymes Electrically Contacted by Mediated Electron‐transfer Biosensors Based on Electrically “Wired” Enzyme Electrodes Bioelectrocatalyzed Synthesis by “Wired” Enzyme Assemblies Biofuel Cells Based on “Wired” Enzyme Assemblies The External Control of the Electron‐transfer Process Photochemical Control by Enzyme‐bound Photoisomerizable Units Photochemical Control by Electrode‐bound Photoisomerizable Units Photochemical Control by Mediator‐bound Photoisomerizable Units Conclusion and Perspectives Acknowledgment

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Biomimetic Electron‐Transfer Chemistry of Porphyrins and Metalloporphyrins

Fukuzumi¹,

Imahori²

2001

Electron Transfer in Chemistry

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Long‐Range Electron Transfer in Peptides and Proteins

Cited by 54 publications

References 159 publications

Distance dependence of long‐range electron transfer through helical peptides

Distance dependence of long‐range electron transfer through helical peptides

Mediated Electron‐transfer between Redox‐enzymes and Electrode Supports

Biomimetic Electron‐Transfer Chemistry of Porphyrins and Metalloporphyrins

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