Long-range Correlated Glucose Fluctuations in Diabetes

Abstract

Such long-range positive correlation in glucose homeostasis may reflect pathogenic mechanisms of diabetes, i.e., the lack of the tight control in blood glucose regulation. Using modern time series analysis methods such as DFA, continuous evaluation of glucose dynamics could promote better diagnoses and prognoses of diabetes and a better understanding of the fundamental mechanism of glucose dysregulation in diabetes.

Differences in complexity of glycemic profile in survivors and nonsurvivors in an intensive care unit: A pilot study*

“…0.29 in healthy volunteers. All of the critically ill patients in our series had DFA values greater than those reported by Ogata et al (23,31), which supports our hypothesis that critical illness and multisystem organ dysfunction are characterized by a loss of complexity in the glycemic profile.…”

Adiponectin Reduces Glucotoxicity-Induced Apoptosis of INS-1 Rat Insulin-Secreting Cells on a Microfluidic Chip

“…Experiments in vitro have provided evidence that chronic persistent hyperglycemia can reduce the mRNA expression of insulin gene in pancreatic islet β -cells (Robertson et al 2007). In addition to persistent hyperglycemia, another commonly accepted circumstance in diabetic patients is the repeated fluctuation in blood sugar (Ogata et al 2007). There are also a few published papers referring to the toxic effect of fluctuating glucose on pancreatic β -cells in vitro (Del Guerra et al 2007).…”

Protection of pancreatic β-cells against glucotoxicity by short-term treatment with GLP-1

“…Fluctuation from hypoglycemia to hyperglycemia is a common and important phenomenon in diabetic patients, in whom the fluctuations are more severe than those in healthy individuals [16]. To induce glucotoxicity by fluctuating glucose levels, INS-1 cells and dispersed islet cells were exposed to fluctuating glucose concentrations from 2.5 mM (low glucose) for 1 h to 17 mM (high glucose) for 48 h, and from 5 mM (low glucose) for 1 h to 25 mM (high glucose) for 48 h, respectively.…”