1999
DOI: 10.1073/pnas.96.21.11713
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Long-range charge hopping in DNA

Abstract: The fundamental mechanisms of charge migration in DNA are pertinent for current developments in molecular electronics and electrochemistry-based chip technology. The energetic control of hole (positive ion) multistep hopping transport in DNA proceeds via the guanine, the nucleobase with the lowest oxidation potential. Chemical yield data for the relative reactivity of the guanine cations and of charge trapping by a triple guanine unit in one of the strands quantify the hopping, trapping, and chemical kinetic p… Show more

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Cited by 413 publications
(443 citation statements)
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“…As shown in Figure 4A, photoirradiation of Duplex II caused efficient cleavage at all GG sites, even at the GG 6 doublet, indicating that the hole injected from the AQ chromophore arrived at the GG 6 site. 38 Addition of the 15-mer ODN 7 to Duplex II to form Triplex III dramatically reduced cleavage at the GG 6 site, while the GG 4 and GG 5 sites were still cleaved. This result strongly suggests that hole transport between the GG 5 and GG 6 sites was suppressed effectively by the binding of ODN 7 to form a partial triplex, whereas the hole injected by the AQ photosensitizer could still migrate to the GG 5 site.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…As shown in Figure 4A, photoirradiation of Duplex II caused efficient cleavage at all GG sites, even at the GG 6 doublet, indicating that the hole injected from the AQ chromophore arrived at the GG 6 site. 38 Addition of the 15-mer ODN 7 to Duplex II to form Triplex III dramatically reduced cleavage at the GG 6 site, while the GG 4 and GG 5 sites were still cleaved. This result strongly suggests that hole transport between the GG 5 and GG 6 sites was suppressed effectively by the binding of ODN 7 to form a partial triplex, whereas the hole injected by the AQ photosensitizer could still migrate to the GG 5 site.…”
Section: Resultsmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9] On the basis of this promising hole transport ability of DNA duplexes and the intrinsic fact that DNA forms highly organized structures, DNA is recognized as a potential candidate material for nanoscale molecular devices. [10][11][12][13][14][15][16][17][18] To utilize DNA duplexes in this way, DNA duplexes need to be equipped with an on/off switching functionality of their hole transport efficiency.…”
Section: Introductionmentioning
confidence: 99%
“…Time resolved spectroscopy and steady state oxidative damage analyses point toward an incoherent multistep hopping mechanism, 49,60,[76][77][78][79][80][81][82] in which the hole migrates essentially by hopping between G neighboring sites, 59 with the possibility of tunnelling over short distances, when two G sites are separated by two or almost three A and/or T sites. The hopping process is in most of the cases slow, thus limiting potential applications to nano-scale electronic devices, 83,84 but since significant enhancements of HT rates have been observed both by including in the strand modified nucleobases, with a lower oxidation potentials than natural ones, or by using sequences consisting of blocks of homopurine sequences, 85,86 research in the field is still very active.…”
Section: Coherent Hole Transfer In Dnamentioning
confidence: 99%
“…Both the problem and the approach to its solution are similar to the one solved earlier for random charge injection. 6 The probability of finding the hole at the nth trapping site W(n) is obtained in the form (13) that further turns into eq 13a in the diffusion-controlled case of k t ≫ k (ω→∞).…”
Section: Steady-state Solutionmentioning
confidence: 99%