“…The protein product of KCNQ1 (Kv7.1 α‐subunit), when co‐expressed with its β‐subunit, encoded by KCNE1 , forms the slowly activating channel that conducts I KS (Ackerman et al., 2011; Nerbonne & Kass, 2005). The first known subtypes of inherited LQTS, LQT1–3, which account for the majority of congenital LQTS, were distinguished by mapping to distinct chromosomes, with LQT1 mapping to chromosome 11 (Keating et al., 1991). LQT1, found to be due to mutations in the KCNQ1 gene, is the most common LQTS variant, representing 30–35% of all congenital LQTS (Ackerman et al., 2011).…”