Long-Pulsed Dye Laser of 595 nm in Combination With Pigment-Specific Modalities for a Patient Exhibiting Increased Vascularity Within Lesions of Melasma

Geddes, Elizabeth R.; Stout, Ashlyn B.; Friedman, Paul M.

doi:10.1097/dss.0000000000000652

Cited by 7 publications

(10 citation statements)

References 5 publications

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“…Pulsed dye laser in combination with Kligman's trio provided significantly better results compared to the trio alone in a prospective intra-individual comparative trial (Passeron et al, 2011). These results have recently been confirmed by another group (Geddes, Stout, & Friedman, 2016). Unfortunately, pulsed dye laser treatment should be restricted to skin type III and lower as PIH strongly limits the interest of such a laser approach in darker skin types.…”

Section: Therapeutic Significancementioning

confidence: 91%

Melasma, a photoaging disorder

Passeron

Picardo

2018

Pigment Cell Melanoma Res

168

194

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Summary Melasma is a common hyperpigmentary disorder. The impact on the quality of life of affected individuals is well demonstrated, demanding new therapeutic strategies. However, the treatment of melasma remains highly challenging. Melasma is often considered as the main consequence of female hormone stimulation on a predisposed genetic background. Although these two factors do contribute to this acquired pigmentary disorder, the last decade has revealed several other key players and brought new pieces to the complex puzzle of the pathophysiology of melasma. Here, we summarize the latest evidence on the pathophysiology of melasma, and we suggest that melasma might be a photoaging skin disorder affecting genetically predisposed individuals. Such data must be taken into consideration by clinicians as they could have a profound impact on the treatment and the prevention of melasma.

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Section: Therapeutic Significancementioning

confidence: 91%

Melasma, a photoaging disorder

Passeron

Picardo

2018

Pigment Cell Melanoma Res

168

194

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“…Importantly, in skin types IV and higher the risk of PIH is important and the combination approach is no longer superior to Kligman's trio alone for these subgroups. The usefulness of PDL in treating melasma has been confirmed recently …”

Section: Clinical Indicationsmentioning

confidence: 92%

“…The usefulness of PDL in treating melasma has been confirmed recently. 147 Intense pulsed light sources have shown mild to marked improvement of melasma lesions. 52,[148][149][150][151] The risk of PIH remains important but appears to be lower than the one observed with QS lasers.…”

Section: Recommendationmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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Background Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side‐effects. Objective The aim of this review was to give evidence‐based recommendations for the use of lasers and IPLS in the treatment of hyperpigmented lesions. Methods These recommendations were produced for the European Society of Laser Dermatology by a consensus panel made up of experts in the field of pigment laser surgery. Recommendations on the use of lasers and light treatments were made based on the quality of evidence for efficacy, safety, tolerability, cosmetic outcome, patient satisfaction/preference and, where appropriate, on the experts' opinion. Results Lasers and IPLS are very effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments. Conclusion Although potentially very effective, lasers and IPLS cannot be proposed for all types of hyperpigmented lesions. In all cases, precise recognition of the disorder is mandatory for choosing between these devices and other therapeutic approaches.

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“…5 Growing evidence suggests that increases in vascularization and vascular components in melasma lesions may play significant role in the pathogenesis of melasma. 3 Indeed, 595-nm long-pulsed dye lasers targeting vascular components have been found to elicit added improvement and long-lasting effects in melasma treatments. 3,4 Also, a recent study showed that endothelial cells promote skin pigmentation through endothelin receptor activation.…”

Section: Discussionmentioning

confidence: 99%

“…Vascular targeting lasers for melasma have been shown to elicit clinical improvements in the lesions and to decrease recurrence rates thereof. 3,4 In this report, we present a case of refractory ABNOM that showed clinical improvement upon targeting underlying vessels with two sessions of combined picosecond 1,064-nm and wavelength-converted 595-nm Nd:YAG laser treatment.…”

Section: Introductionmentioning

confidence: 97%

Improvement in Acquired Bilateral nevus of ota-Like Macules with Picosecond-Domain Wavelength-converted 595-nm neodymium:Yttrium Aluminium Garnet Laser Treatment

Suk¹,

Cho²

2016

Medical Lasers

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The acquired bilateral nevus of Ota-like macules (ABNOM) is a common dermal pigmentary condition in Asians. Histologically, these lesions are similar to the nevus of Ota. However, ABNOM lesions differ in that melanocytes are located more superficially and clustered perivascularly. To treat ABNOM, various pigment-targeting Q-switched lasers have been used, although the treatment of ABNOM is more difficult than that of nevus of Ota. In this current report, we treated a patient with refractory ABNOM by targeting vessels in ABNOM lesions using a picoseconddomain wavelength-converted 595-nm neodymium:yttrium aluminium garnet (Nd:YAG) laser. The patient showed clinical improvement in underlying vascular components and ABNOM lesions after two sessions of combined treatment with picosecond-domain 1,064-nm and wavelength-converted 595-nm Nd:YAG lasers. Accordingly, we suggest that a similar treatment may be promising as a therapeutic method for treating ABNOM.

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Long-Pulsed Dye Laser of 595 nm in Combination With Pigment-Specific Modalities for a Patient Exhibiting Increased Vascularity Within Lesions of Melasma

Cited by 7 publications

References 5 publications

Melasma, a photoaging disorder

Melasma, a photoaging disorder

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Improvement in Acquired Bilateral nevus of ota-Like Macules with Picosecond-Domain Wavelength-converted 595-nm neodymium:Yttrium Aluminium Garnet Laser Treatment

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