Long-pulse dye laser for photodynamic therapy: Investigations in vitro and in vivo

Karrer, Sigrid; Bäumler, Wolfgang; Abels, Christoph; Hohenleutner, Ulrích; Landthaler, Míchael; Szeimies, Rolf‐Markus

doi:10.1002/(sici)1096-9101(1999)25:1<51::aid-lsm7>3.0.co;2-y

Cited by 109 publications

(51 citation statements)

References 25 publications

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“…As it had been demonstrated that PDT with PDL enables treatment of NMSC equally efficient to non‐coherent light sources, yet at significantly lower pain levels, PDL are frequently used light sources for PDT 12 . Key et al.…”

Section: Introductionmentioning

confidence: 99%

Aesthetic effects of topical photodynamic therapy

Kohl

Torezan

Landthaler

et al. 2010

Acad Dermatol Venereol

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Topical photodynamic therapy has shown to be effective for the treatment of several aspects of skin ageing. Multiple studies have demonstrated improvement of fine wrinkles, mottled hyperpigmentation, tactile roughness and sallowness. These results are supported by immunohistochemical analysis that revealed both upregulation of collagen production and increased epidermal proliferation. Neocollagenesis as an indirect dermal effect of photodynamic therapy is stimulated through cytokine induction. This article reviews the available literature for photodynamic rejuvenation while discussing cosmetic effects, light sources, adverse effects and the mechanism of action.

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Section: Introductionmentioning

confidence: 99%

Aesthetic effects of topical photodynamic therapy

Kohl

Torezan

Landthaler

et al. 2010

Acad Dermatol Venereol

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“…In the long‐term follow‐up, non‐coherent red light sources have shown good results when using MAL for acne treatment 7,8,12 . Compared with these results, the pulsed light source demonstrated good outcome in the treatment of superficial actinic keratosis 13 . The pulsed light source transmits energy in the several milliseconds time window.…”

Section: Discussionmentioning

confidence: 99%

Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light

et al. 2012

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Various methods of photodynamic therapy (PDT) for acne have been introduced. However, comparative studies among them are still needed. We performed this study to compare the effect of methyl aminolevulinate (MAL) PDT for acne between red light and intense pulsed light (IPL). Twenty patients were enrolled in this eight-week, prospective, split-face study. We applied MAL cream over the whole face with a three-hour incubation time. Then patients were irradiated with 22 J/cm(2) of red light on one-half of the face and 8-10 J/cm(2) of IPL on the other half during each treatment session. We performed three treatment sessions at two-week intervals and followed-up patients until four weeks after the last session. Inflammatory and non-inflammatory acne lesions were reduced significantly on both sides. The red light side showed a better response than the IPL side after the first treatment. Serious adverse effects after treatment were not observed. MAL-PDT with red light and IPL are both an effective and safe modality in acne treatment. Red light showed a faster response time than IPL. After multiple sessions, both light sources demonstrated satisfactory results. We suggest that reducing the total dose of red light is desirable when performing MAL-PDT in Asian patients with acne compared with Caucasians.

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“…For a successful PDT-treatment using ALA-or MAL-PDT both laser and incoherent light sources can be used and there is no difference regarding the profile of light. Even pulsed laser light sources matching one of the Q-bands at 585 nm have comparable results to an incoherent light source in the treatment of AK [22]. Also the use of a long-pulsed dye laser at 595 nm seems to be effective for the same indication [19].…”

Section: Light Sources and Action Mechanismmentioning

confidence: 99%

Photodynamic Therapy and Skin Cancer

Papakonstantinou¹,

Löhr²,

Raap³

2018

Dermatologic Surgery and Procedures

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Non-melanoma skin cancer (NMSC) is the most common type of cancer among white skin individuals worldwide with an increasing incidence over the last years. NMSC is mostly treated with surgical or non-invasive methods such as cryotherapy or topical chemotherapeutics. Over the last years, there has been a rapidly growing interest in the use of photodynamic therapy (PDT) which is a well-tolerated, safe and effective alternative treatment option. PDT involves a photosensitizer, a light source and tissue oxygen and is based on a photo-oxidation reaction in the target tissue which results to a selective destruction of the cancer cells. PDT has been approved for treatment of actinic keratosis, Bowen's disease and basal cell carcinoma in Europe. Off-label uses include treatment of invasive squamous cell carcinoma, cutaneous T-cell lymphoma, Kaposi's sarcoma, Paget's disease and prevention of recurrence of squamous cell carcinoma in organ-transplant recipients. Also combination of PDT with other treatment options such as cryotherapy, surgery and topical therapies has been reported with improved efficacy, tolerability and long-term results. Development of novel photosensitizers and light sources together with targeted delivery systems will increase specificity, efficiency and treatment field of PDT in the future. This chapter aims to give the reader an overview of the important applications of PDT, including indications, approved treatments, advantages and disadvantages of this method such as future trends.

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Long-pulse dye laser for photodynamic therapy: Investigations in vitro and in vivo

Cited by 109 publications

References 25 publications

Aesthetic effects of topical photodynamic therapy

Aesthetic effects of topical photodynamic therapy

Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light

Photodynamic Therapy and Skin Cancer

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