Long Persistence of a Streptococcus pneumoniae 23F Clone in a Cystic Fibrosis Patient

Rieger, Martin; Mauch, H.; Hakenbeck, Regine

doi:10.1128/msphere.00201-17

Cited by 5 publications

(3 citation statements)

References 75 publications

(91 reference statements)

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“…There is evidence, however, that transfer of homologous DNA seems to occur between S. mitis and S. oralis (Kilian et al, 2008). A recent report of in vivo interspecies gene transfer by Rieger et al (2017) revealed the acquisition of a pbp2x mosaic gene of S. pneumoniae by a S. mitis strain, supporting a “two-way street” in gene exchange between the two species. Since the pbp gene is close to the capsule locus, recombination events in this region may also facilitate the transfer of capsule genes from one species to the other.…”

Section: Horizontal Gene Transfer In Streptococcus Pneumoniae and Clomentioning

confidence: 93%

Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications

Salvadori

Junges

Morrison

et al. 2019

Front. Cell. Infect. Microbiol.

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The mitis group of streptococci comprises species that are common colonizers of the naso-oral-pharyngeal tract of humans. Streptococcus pneumoniae and Streptococcus mitis are close relatives and share ~60–80% of orthologous genes, but still present striking differences in pathogenic potential toward the human host. S. mitis has long been recognized as a reservoir of antibiotic resistance genes for S. pneumoniae , as well as a source for capsule polysaccharide variation, leading to resistance and vaccine escape. Both species share the ability to become naturally competent, and in this context, competence-associated killing mechanisms such as fratricide are thought to play an important role in interspecies gene exchange. Here, we explore the general mechanism of natural genetic transformation in the two species and touch upon the fundamental clinical and evolutionary implications of sharing similar competence, fratricide mechanisms, and a large fraction of their genomic DNA.

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Section: Horizontal Gene Transfer In Streptococcus Pneumoniae and Clomentioning

confidence: 93%

Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications

Salvadori

Junges

Morrison

et al. 2019

Front. Cell. Infect. Microbiol.

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“…The genes coding for these low affinity PBPs are mosaic genes formed by recombination between strains, in many cases between pneumococcus and other streptococcal species ( Dowson et al, 1989 ; Sibold et al, 1992 ; Chi et al, 2007 ; Sauerbier et al, 2012 ; Mousavi et al, 2017 ). A recent study captured a gene exchange event between a strain of S. mitis and pneumococcus isolated from a longitudinal study in a cystic fibrosis patient ( Rieger et al, 2017 ). An additional example for a functional class of genes that undergoes exchange across species is peptides implicated in cell-cell communication.…”

Section: Gene Transfer In the Pneumococcus: Implications For The Pangmentioning

confidence: 99%

Puzzling Over the Pneumococcal Pangenome

Hiller

Sá-Leão

2018

Front. Microbiol.

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The Gram positive bacterium Streptococcus pneumoniae (pneumococcus) is a major human pathogen. It is a common colonizer of the human host, and in the nasopharynx, sinus, and middle ear it survives as a biofilm. This mode of growth is optimal for multi-strain colonization and genetic exchange. Over the last decades, the far-reaching use of antibiotics and the widespread implementation of pneumococcal multivalent conjugate vaccines have posed considerable selective pressure on pneumococci. This scenario provides an exceptional opportunity to study the evolution of the pangenome of a clinically important bacterium, and has the potential to serve as a case study for other species. The goal of this review is to highlight key findings in the studies of pneumococcal genomic diversity and plasticity.

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“…It is assumed that gene exchange by transformation has contributed significantly to the increasing incidence of penicillin-resistant S. pneumoniae [ 163 , 164 ], and this is probably also the case in S. suis . In this context, the acquisition of a pbp2x gene of S. pneumoniae by a Streptococcus mitis strain has been reported [ 165 ]. Thus, exchange of pbp sequences could quickly generate β-lactam-resistant strains by introducing multiple simultaneously occurring substitutions in a single gene.…”

Section: Transfer Of Antibiotic-resistance Genesmentioning

confidence: 99%

How Streptococcus suis escapes antibiotic treatments

Uruén

Garcia

Fraile

et al. 2022

Vet Res

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Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and humans. S. suis infections are responsible for large economic losses in pig production. The lack of effective vaccines to prevent the disease has promoted the extensive use of antibiotics worldwide. This has been followed by the emergence of resistance against different classes of antibiotics. The rates of resistance to tetracyclines, lincosamides, and macrolides are extremely high, and resistance has spread worldwide. The genetic origin of S. suis resistance is multiple and includes the production of target-modifying and antibiotic-inactivating enzymes and mutations in antibiotic targets. S. suis genomes contain traits of horizontal gene transfer. Many mobile genetic elements carry a variety of genes that confer resistance to antibiotics as well as genes for autonomous DNA transfer and, thus, S. suis can rapidly acquire multiresistance. In addition, S. suis forms microcolonies on host tissues, which are associations of microorganisms that generate tolerance to antibiotics through a variety of mechanisms and favor the exchange of genetic material. Thus, alternatives to currently used antibiotics are highly demanded. A deep understanding of the mechanisms by which S. suis becomes resistant or tolerant to antibiotics may help to develop novel molecules or combinations of antimicrobials to fight these infections. Meanwhile, phage therapy and vaccination are promising alternative strategies, which could alleviate disease pressure and, thereby, antibiotic use.

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Long Persistence of a Streptococcus pneumoniae 23F Clone in a Cystic Fibrosis Patient

Cited by 5 publications

References 75 publications

Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications

Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications

Puzzling Over the Pneumococcal Pangenome

How Streptococcus suis escapes antibiotic treatments

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