Long-period fiber grating sensor for detection of viruses

Janczuk-Richter, Marta; Dominik, Magdalena; Roźniecka, Ewa; Koba, Marcin; Mikulic, Predrag; Bock, Wojtek J.; Łoś, Marcin; Śmietana, Mateusz; Niedziółka‐Jönsson, Joanna

doi:10.1016/j.snb.2017.04.148

Cited by 85 publications

(31 citation statements)

References 36 publications

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“…Each time a significant shift of the resonance wavelength versus noise for 1 ng/mL of added VLP was obtained, and the results are in agreement. Spectral changes observed for VLPs detection were comparable with those obtained for bacteriophage detection with an LPFG sensor [27]. We observed a decrease in sensitivity for higher norovirus VLP concentrations, indicating a possible saturation of receptors with VLPs ( Figure 5B).…”

Section: Detection Of Norovirus Vlps With Lpfg Sensorsupporting

confidence: 78%

“…The LPFGs with the grating period Λ = 226.8 µm were written in a 5-cm-long section of hydrogen-loaded Corning SMF-28e fiber according to [27]. During the fabrication process, the optical transmission of the fiber was monitored (Yokogawa AQ6370B spectrum analyzer and Leukos SM30 supercontinuum white light laser).…”

Section: Lpfg Fabrication and Measurementsmentioning

confidence: 99%

“…Due to slightly lower RI sensitivity of LPFG sensor used for selectivity measurements, the shift for 10 ng/mL norovirus VLP was lower than in the case of previous measurements, but it was still reasonably large. The LPFG sensor can be reused after the regeneration process, as described in [27].…”

Section: Detection Of Norovirus Vlps With Lpfg Sensormentioning

confidence: 99%

“…In addition to high sensitivity, the LPFG does not introduce any additional insertion losses or reflections. LPFG sensors may offer very high RI sensitivity and have already been used as biosensors for the detection of proteins [19][20][21], nucleic acids [22,23], bacteria [24][25][26], and bacteriophages [27]. The main advantages of LPFG biosensors are the real-time and label-free operation, possible miniaturization, and remote sensing capabilities.…”

Section: Introductionmentioning

confidence: 99%

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Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Janczuk-Richter

Gromadzka

Richter

et al. 2020

Sensors

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Since the norovirus is the main cause of acute gastroenteritis all over the world, its fast detection is crucial in medical diagnostics. In this work, a rapid, sensitive, and selective optical fiber biosensor for the detection of norovirus virus-like particles (VLPs) is reported. The sensor is based on highly sensitive long-period fiber gratings (LPFGs) coated with antibodies against the main coat protein of the norovirus. Several modification methods were verified to obtain reliable immobilization of protein receptors on the LPFG surface. We were able to detect 1 ng/mL norovirus VLPs in a 40-min assay in a label-free manner. Thanks to the application of an optical fiber as the sensor, there is a possibility to increase the user’s safety by separating the measurement point from the signal processing setup. Moreover, our sensor is small and light, and the proposed assay is straightforward. The designed LPFG-based biosensor could be applied in both fast norovirus detection and in vaccine testing.

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Section: Detection Of Norovirus Vlps With Lpfg Sensorsupporting

confidence: 78%

Section: Lpfg Fabrication and Measurementsmentioning

confidence: 99%

Section: Detection Of Norovirus Vlps With Lpfg Sensormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Janczuk-Richter

Gromadzka

Richter

et al. 2020

Sensors

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“…More important however, is their use as sensors as they exhibit many and important advantages over traditional electrical sensors, offering high precision, stability over time, immunity to electromagnetic interference, support for long range detection, suitability for use in explosive environments, and inherently offering multiplexed sensing via a single fiber-optic channel [6][7][8]. Because of their advantages they are applied in a wide variety of fields such as industrial automation, energy, automotive, aerospace, security and even medicine [9][10]. The use of FBG allows measurements of physical quantities and parameters such as mechanical stresses, displacement, pressure and temperature change [4].…”

Section: Introductionmentioning

confidence: 99%

Transmission line method for the simulation of fiber Bragg gratings

et al. 2019

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A new method for the analysis and design of fiber Bragg gratings (FBG) based on the theory of transmission lines has been developed and verified both theoretically and experimentally. The method is an extension of the Coupled Mode Theory and utilizes the equivalent transmission lines in order to simulate any type of grating, with an easy and direct implementation. The method provides the ability to analyze the optical devices without using full wave approaches, while also facilitating the incorporation of core materials with a complex or nonlinear refractive index, non-uniform distributions of the grating's refractive index, and tilted and phase shifted gratings. The approach also allows the design of the grating for a given reflection spectra. Numerical results of the method's application on a randomly varied inscription of the refractive index of a FBG have also been simulated and discussed. Using this method, the characteristics of an Erbium-Doped FBG have been simulated and the predictions verified experimentally.

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Quantitative Assessment of Fungal Biomarkers in Clinical Samples via an Interface‐Modulated Optical Fiber Biosensor

Chen,

Wu,

Zhao

et al. 2024

Advanced Materials

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Invasive fungal infections pose a significant public health threat. The lack of precise and timely diagnosis is a primary factor contributing to the significant increase in patient mortality rates. Here, we report an interface‐modulated biosensor utilizing an optical fiber for quantitative analysis of fungal biomarkers at the early stage for point‐of‐care testing. By integrating surface refractive index modulation and plasmon enhancement, we successfully optimized the sensor to achieve the highest sensitivity in a directional response to the target analytes. As a result, we developed a compact fiber optic sensor with rapid response time, cost‐effectiveness, exceptional sensitivity, stability, and specificity. This sensor can successfully identify the biomarkers of specific pathogens from blood or other tissue specimens in animal models. It quantifies clinical blood samples with precision and effectively discriminates between negative and positive cases, thereby providing timely alerts to potential patients. It significantly reduces the detection time of fungal infection to only 30 minutes. Additionally, this approach exhibits remarkable stability and achieves a limit of detection three orders of magnitude lower than existing methods. It overcomes the limitations of existing detection methods, including a high rate of misdiagnosis, prolonged detection time, elevated costs, and the requirement for stringent laboratory conditions.This article is protected by copyright. All rights reserved

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Long-period fiber grating sensor for detection of viruses

Cited by 85 publications

References 36 publications

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Transmission line method for the simulation of fiber Bragg gratings

Quantitative Assessment of Fungal Biomarkers in Clinical Samples via an Interface‐Modulated Optical Fiber Biosensor

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