Long Noncoding RNAs-Related Diseases, Cancers, and Drugs

Tang, Jen‐Yang; Lee, Jin‐Ching; Chang, Yun‐chien; Hou, Ming‐Feng; Huang, Hurng‐Wern; Liaw, Chih‐Chuang; Chang, Hsueh‐Wei

doi:10.1155/2013/943539

Cited by 63 publications

(53 citation statements)

References 103 publications

(101 reference statements)

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“…Accumulated evidences suggested that lncRNAs function as the responder for stimulus from drugs and crucially regulate disease progresses by association with its downstream signaling pathway (Tang et al, ; Lin et al, ). Our present study defined lncRNA‐MALAT1 as a key regulator in mediating cardio‐protective effects of fentanyl against I/R injury.…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia‐reperfusion injury

Zhao

Meng

et al. 2016

Cell Biology International

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Long non-coding (lncRNA) MALAT1 can be increased by hypoxia or ischemic limbs. Also, downregulation of MALAT1 contributes to reduction of cardiomyocyte apoptosis. However, the functional involvement of MALAT1 in myocardial ischemia-reperfusion (I/R) injury has not been defined. This study investigated the functional involvement of lncRNA-MALAT1 in cardioprotective effects of fentanyl. HL-1, a cardiac muscle cell line from the AT-1 mouse atrial cardiomyocyte tumor lineage was pre-treated with fentanyl and generated cell model of hypoxia-reoxygenation (H/R). Relative expression of MALAT1, miR-145, and Bnip3 mRNA in cells was determined by quantitative real-time PCR. Cardiomyocyte H/R injury was indicated by lactate dehydrogenase (LDH) release and cell apoptosis. The results showed that fentanyl abrogates expression of responsive gene for H/R and induces downregulation of MALAT1 and Bnip3 and upregulation of miR-145. We found that miR-145/Bnip3 pathway was negatively regulated by MALAT1 in H/R-HL-1 cell with or without fentanyl treatment. Moreover, both MALAT1 overexpression and miR-145 knockdown reverse cardioprotective effects of fentanyl, as indicated by increase in LDH release and cell apoptosis. The reversal effect of MALAT1 for fentanyl is confirmed in cardiac ischemia/reperfusion (I/R) mice. In summary, lncRNA-MALAT1 is sensitive to H/R injury and abrogates cardioprotective effects of Fentanyl by negatively regulating miR-145/Bnip3 pathway.

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Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia‐reperfusion injury

Zhao

Meng

et al. 2016

Cell Biology International

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“…With the advance of high resolution microarray and genome wide sequencing technology, lncRNAs have recently caught increasing attention ( Ma et al, 2012;Tang et al, 2013;Liu et al, 2014). Some studies suggest that dysexpression of lncRNAs is associated with numerous diseases including cancer (Wapinski and Chang, 2011;Tang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest that dysexpression of lncRNAs is associated with numerous diseases including cancer (Wapinski and Chang, 2011;Tang et al, 2013). Furthermore, lncRNAs have been identified to play a major role in the development and progression of different cancers.…”

Section: Discussionmentioning

confidence: 99%

Expression and Prognostic Significance of lncRNA MALAT1 in Pancreatic Cancer Tissues

Liu¹,

Chen²,

Dang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

135

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“…LncRNA have been shown to regulate gene expression by a series of mechanisms, including not only transcription and post‐transcription processing, but also genomic imprinting, chromatin modification and regulation of protein function . Accumulating studies indicate that the deregulated lncRNA play a critical role in the pathogenesis of various human cancers, such as colorectal cancer, breast cancer, gastric cancer, bladder cancer, esophageal cancer, and so on . For instance, as an oncogene, Malat1 can promote the growth and metastasis of small cell lung cancer and might be used as a new biomarker to determine the prognosis of patients .…”

mentioning

confidence: 99%

“…(8,9) Accumulating studies indicate that the deregulated lncRNA play a critical role in the pathogenesis of various human cancers, such as colorectal cancer, breast cancer, gastric cancer, bladder cancer, esophageal cancer, and so on. (10)(11)(12) For instance, as an oncogene, Malat1 can promote the growth and metastasis of small cell lung cancer and might be used as a new biomarker to determine the prognosis of patients. (13) HOX transcript antisense intergenic RNA (HOTAIR) reprograms the chromatin state and its overexpression in tumor tissues is correlated with cancer metastasis.…”

mentioning

confidence: 99%

Long non‐coding RNA Fer‐1‐like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR‐106a‐5p in colon cancer

et al. 2015

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Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been confirmed to play crucial regulatory roles in tumor progression. It exerts an impact on tumor suppression and functions as a competing endogenous RNA (ceRNA) by sponging miR-106a-5p in gastric cancer. However, its clinical significance in colon cancer is completely unknown. The aim of the present study was to annotate the role of FER1L4 and its clinical value in colon cancer. The results showed the aberrant expression of FER1L4 and miR-106a-5p in colon cancer tissues. In addition, significant negative correlation between FER1L4 and miR-106a-5p expression levels was observed. Among the colon cancer cell lines, FER1L4 levels were relatively lower, with concurrent high levels of miR-106a-5p. Restoration of FER1L4 decreased the expression of miR-106a-5p, and had a significant influence on colon cancer cell proliferation, migration and invasion. The FER1L4 expression was correlated with depth of tumor invasion, lymph node metastasis, vascular invasion and clinical stage. Moreover, striking differences in overall survival and disease-free survival were observed for the cases with both low FER1L4 expression and high miR-106a-5p expression compared with cases with high FER1L4 expression and low miR-106a-5p expression. Circulating FER1L4 and miR-106a-5p levels were decreased and increased, respectively, in colon cancer patients after surgery. Our findings indicated that FER1L4 could exert a tumor suppressive impact on colon cancer, which at least, in part, through suppressing miR-106a-5p expression, and depletion of FER1L4, alone or combined with overexpression of miR-106a-5p, is predictive of poor prognosis in colon cancer and may play a crucial role in cancer prevention and treatment.

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Long Noncoding RNAs-Related Diseases, Cancers, and Drugs

Cited by 63 publications

References 103 publications

Long non‐coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia‐reperfusion injury

Long non‐coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia‐reperfusion injury

Expression and Prognostic Significance of lncRNA MALAT1 in Pancreatic Cancer Tissues

Long non‐coding RNA Fer‐1‐like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR‐106a‐5p in colon cancer

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