Long noncoding RNAs regulate intrauterine adhesion and cervical cancer development and progression

Wang, Xuemei; Gu, Yu; Zhang, Leichao; Ma, Jinghong; Xia, Yong; Wang, Xueju

doi:10.1016/j.semcdb.2023.02.007

Cited by 6 publications

(4 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By regulating the expression of key genes, they regulate proliferation, apoptosis, cell cycle, migration and invasion, EMT and cancer stem cells, and participate in chemotherapy resistance, radiation resistance and immunotherapy. It is involved in the occurrence and development of cervical cancer [ 32 ]. Whether PCGEM1 has a similar mechanism in CC requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

LIU,

WANG

et al. 2024

View full text Add to dashboard Cite

At present, the role of many long non-coding RNAs (lncRNAs) as tumor suppressors in the formation and development of cervical cancer (CC) has been studied. However, lncRNA prostate cancer gene expression marker 1 (PCGEM1), whose high expression not only aggravates ovarian cancer but also can induce tumorigenesis and endometrial cancer progression, has not been studied in CC. The objective of this study was to investigate the expression and the underlying role of PCGEM1 in CC. The relative expression of PCGEM1 in CC cells was detected by real-time PCR. After the suppression of PCGEM1 expression by shRNA, the changes in the proliferation, migration, and invasion capacities were detected via CCK-8 assay, EdU assay, and colony formation assay wound healing assay. Transwell assay and the changes in expressions of epithelial-to-mesenchymal transition (EMT) markers were determined by western blot and immunofluorescence. The interplay among PCGEM1, miR-642a-5p, and kinesin family member 5B (KIF5B) was confirmed by bioinformatics analyses and luciferase reporter assay. Results showed that PCGEM1 expressions were up-regulated within CC cells. Cell viabilities, migration, and invasion were remarkably reduced after the suppression of PCGEM1 expression by shRNA in Hela and SiHa cells. N-cadherin was silenced, but E-cadherin expression was elevated by sh-PCGEM1. Moreover, by sponging miR-642a-5p in CC, PCGEM1 was verified as a competitive endogenous RNA (ceRNA) that modulates KIF5B levels. MiR-642a-5p downregulation partially rescued sh-PCGEM1's inhibitory effects on cell proliferation, migration, invasion, and EMT process. In conclusion, the PCGEM1/miR-642a-5p/KIF5B signaling axis might be a novel therapeutic target in CC.This study provides a research basis and new direction for targeted therapy of CC.

show abstract

Section: Discussionmentioning

confidence: 99%

LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

LIU,

WANG

et al. 2024

View full text Add to dashboard Cite

show abstract

“…HA, known for its high biocompatibility and natural properties, serves as a crucial barrier in promoting endometrial repair and inhibiting excessive fibrosis 228,229 . The clinical trade name is “Ankang Gong” (related properties and cutting‐edge research will be described later) 230 . In early clinical trials of HA alone, SeiedeZahra GhanadzadehTafti found that HA can reduce area of fibrotic tissue after hysteroscopic surgery 231 .…”

Section: Diseases and Clinical Regenerative Interventions In Cyclical...mentioning

confidence: 99%

“…228,229 The clinical trade name is "Ankang Gong" (related properties and cutting-edge research will be described later). 230 In early clinical trials of HA alone, SeiedeZahra Ghanadzade-hTafti found that HA can reduce area of fibrotic tissue after hysteroscopic surgery. 231 Several prospective studies have shown that HA reduces adhesions compared with IUDs or balloons.…”

Section: 26mentioning

confidence: 99%

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hu,

Wu,

Yong

et al. 2023

MedComm

View full text Add to dashboard Cite

The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue‐engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies.

show abstract

“…Cervical cancer is the fourth leading cause of cancer-related death in women [109]. It develops from the cells of the cervix, usually caused by infection with human papilloma virus (HPV).…”

Section: Cervical Cancermentioning

confidence: 99%

Hsa-miR-665 Is a Promising Biomarker in Cancer Prognosis

Guan,

Pavani,

Chunduru

et al. 2023

Cancers

View full text Add to dashboard Cite

Biomarkers are biomolecules used to identify or predict the presence of a specific disease or condition. They play an important role in early diagnosis and may be crucial for treatment. MicroRNAs (miRNAs), a group of small non-coding RNAs, are more and more regarded as promising biomarkers for several reasons. Dysregulation of miRNAs has been linked with development of several diseases, including many different types of cancer, and abnormal levels can be present in early stages of tumor development. Because miRNAs are stable molecules secreted and freely circulating in blood and urine, they can be sampled with little or no invasion. Here, we present an overview of the current literature, focusing on the types of cancers for which dysregulation of miR-665 has been associated with disease progression, recurrence, and/or prognosis. It needs to be emphasized that the role of miR-665 sometimes seems ambiguous, in the sense that it can be upregulated in one cancer type and downregulated in another and can even change during the progression of the same cancer. Caution is thus needed before using miR-665 as a biomarker, and extrapolation between different cancer types is not advisable. Moreover, more detailed understanding of the different roles of miR-665 will help in determining its potential as a diagnostic and prognostic biomarker.

show abstract

Long noncoding RNAs regulate intrauterine adhesion and cervical cancer development and progression

Cited by 6 publications

References 78 publications

LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hsa-miR-665 Is a Promising Biomarker in Cancer Prognosis

Contact Info

Product

Resources

About