volume 6, issue 12, P992-1009 2014
DOI: 10.18632/aging.100710
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Ioannis Grammatikakis, Amaresh C. Panda, Kotb Abdelmohsen, Myriam Gorospe

Abstract: During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emergi…

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