Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms

Abstract

Endometriosis refers to a benign chronic gynecological disorder, and is defined as the ectopic growth of endometrium in pelvic cavity. Endometriosis affects about 10% of reproductive-aged women. Unfortunately, the pathogenesis of endometriosis remains obscure, and the disease witnesses a lack of effective therapy approaches. Therefore, more research needs to be performed to throw light on endometriosis, its pathogenesis, and therapy. Long noncoding RNAs (lncRNAs), which are defined as functional cellular RNA longer than 200 nucleotides, have been implicated in many chronic disorders. It has been suggested that lncRNAs are closely related to the endometriosis process. Nevertheless, the molecular mechanisms by which lncRNAs associate with endometriosis should be elucidated more detailed. In our brief review, we first exhibit the aberrant lncRNAs expression in endometriosis. Then, we talk about the molecular mechanisms underlying lncRNAs in endometriosis. Finally, we also present the potential of lncRNAs as biomarkers for endometriosis.

Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

“…Nevertheless, the molecular mechanisms by which lncRNAs bind to endometriosis need to be explained in more detail. In summary, lncRNAs show potential as biomarkers of endometriosis [ 176 ]. However, the clinical significance and biological mechanism of lncRNA in the development of endometriosis remain largely unknown.…”

Epigenetic modification mechanisms involved in keloid: current status and prospect

“…LncRNAs are a heterogeneous population of RNA molecules that are 200 nucleotides in length with limited protein-coding potential [34]. Recently, thousands of lncRNAs have been reported to be essential regulatory molecules in modulating cellular physiology and functions through transcriptional activation, transcriptional interference, and intranuclear transport, also thanks to high-throughput sequencing and bioinformatics technologies [35,36]. Dysregulated expression of lncRNAs is essential during the processes of several human fibrotic diseases, especially keloid.…”

New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments

“…LncRNAs represent the largest category of ncRNAs and their relationship to endometriosis has recently been reviewed [ 52 , 53 ]. One outstanding feature of lncRNAs is their ability to regulate gene expression by various mechanisms, one of which is acting as a molecular sponge for miRNAs [ 54 ].…”