Long noncoding RNAs in aging and age-related diseases

Kour, Sukhleen; Rath, Pramod C.

doi:10.1016/j.arr.2015.12.001

Cited by 98 publications

(44 citation statements)

References 245 publications

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“…A recent review summarized the lncRNAs related to senescence and aging process (Kour & Rath, 2016). However, as functions of most of lncRNAs are still unknown, the lncRNAs’ relationship to aging is limited to their expression changes during aging.…”

Section: Molecular Links Between Aging and Admentioning

confidence: 99%

“…However, as functions of most of lncRNAs are still unknown, the lncRNAs’ relationship to aging is limited to their expression changes during aging. In contrast to the long list of aging‐associated lncRNAs (30 lncRNAs in (Kour & Rath, 2016)), there are only six lncRNAs, BACE1‐AS, 51A, 17A, NDM29, BC200, and NAT‐Rad18, known to be associated with AD (Luo & Chen, 2016). …”

Section: Molecular Links Between Aging and Admentioning

confidence: 99%

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Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.

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Section: Molecular Links Between Aging and Admentioning

confidence: 99%

Section: Molecular Links Between Aging and Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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“…In addition, mutations of somatic DNA and proteotoxicity caused by the accumulation of misfolded proteins underlie normal aging, and proteostasis is an important component of longevity mechanisms23. Regarding RNA, several neurodegenerative disorders are associated with defects in RNA-binding protein function45, and many non-coding RNAs, such as microRNAs and long non-coding RNAs, play regulatory roles in longevity678. In addition, proper RNA splicing is crucial for longevity910.…”

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confidence: 99%

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

et al. 2017

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Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations.

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“…Mechanistic studies of the aging process have provided increasing evidence that non-coding RNAs are important players in aging 16, 40 . We have previously shown that an abnormally low expression of microRNA-16 could potentially lead to APP protein accumulation in senescence-accelerated mouse prone 8 (SAMP8) mice 41 .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, recent studies have indicated that altered expression of lncRNAs is closely associated with aging and diseases such as cancer, neurodegenerative disorders and cardiovascular diseases 16, 17 . Moreover, lncRNAs have been implicated to play important roles in the development of sensory organs and related diseases 18, 19 , although any role of lncRNAs in olfactory function or related diseases remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb

Wang

Liu

Jiao

et al. 2017

Sci Rep

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Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanisms underlying this impairment remain unclear. In the current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) and long non-coding RNAs (lncRNAs) in OBs from three groups of mice of different ages (2 months-old young adults, 6 months-old mature adults and 20 months-old aged adults), for their potential roles in olfactory impairment. Gene Ontology and pathway analysis results showed that the differentially expressed PCGs in the OBs from aged mice were mainly associated with signal transduction, regulation of gene expression and cellular microenvironment. Similarly, gene set enrichment analysis identified two differentially and inversely expressed lncRNAs (NONMMUT004524 and NONMMUT000384), both of which were significantly associated with neuroactive ligand-receptor interaction pathway in the OBs of aged mice. These findings suggest that a decline of olfactory function in aged mice may be linked to differential expression of specific lncRNAs and their potentially adverse effects on the neuroactive ligand-receptor interaction pathway in the OB.

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Long noncoding RNAs in aging and age-related diseases

Cited by 98 publications

References 245 publications

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb

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