Long Noncoding RNAs and Circular RNAs in the Metabolic Reprogramming of Lung Cancer: Functions, Mechanisms, and Clinical Potential

Abstract

As key regulators of gene function, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are generally accepted to be involved in lung cancer pathogenesis and progression. Recent research has clarified the phenomenon of metabolic reprogramming in lung cancer because of its significant role in tumor proliferation, migration, invasion, metastasis, and other malignant biological behaviors. Emerging evidence has also shown a relationship between the aberrant expression of lncRNAs and circRNAs and metabolic reprogramming in lung cancer tumorigenesis. This review provides insight regarding the roles of different lncRNAs and circRNAs in lung cancer metabolic reprogramming, by how they target transporter proteins and key enzymes in glucose, lipid, and glutamine metabolic signaling pathways. The clinical potential of lncRNAs and circRNAs as early diagnostic biomarkers and components of therapeutic strategies in lung cancer is further discussed, including current challenges in their utilization from the bench to the bedside and how to adopt a proper delivery system for their therapeutic use.

Circ_0003028 enhances the proliferation and glycolytic capacity and suppresses apoptosis in non-small cell lung cancer cells via the miR-1305/miR-1322-SLC5A1 axis

“…However, the functions of the vast majority of circRNAs have not yet been discovered. Previous reports have indicated that circ_0003028 expression is elevated in NSCLC ( 12 ), which could also accelerate the proliferation, angiogenesis, and metastasis of NSCLC cells ( 14 ). We further verified the circularity and stability of circ_0003028 and revealed the high expression of circ_0003028 in NSCLC tissues.…”

“…Hsa_circ_0000190 was directly involved in EGFR-MAPK-ERK signaling and might serve as a potential therapeutic target for the treatment of non-small cell lung carcinoma ( 11 ). Through literature analysis, we discovered that circ_0003028 was highly expressed in NSCLC ( 12 ), also differentially expressed circRNAs, including hsa_circ_0003028 had diagnostic value in NSCLC ( 13 ), and circ_0003028 also could enhance the proliferation, angiogenesis, and metastasis of NSCLC cells ( 14 ). According to the circBase database, circ_0003028 is located in chr14:66028054-66028484, the spliced length is 430 bp, the best transcript is NM_178155, and the gene symbol is fucosyltransferase 8 ( FUT8 ).…”