Long Noncoding RNA TRIM52-AS1 Sponges miR-514a-5p to Facilitate Hepatocellular Carcinoma Progression Through Increasing MRPS18A

Zhou, Chengyu; Chen, Zhen; Peng, Changli; Chen, Changyong; Li, Haiping

doi:10.1089/cbr.2019.3271

Cited by 17 publications

(13 citation statements)

References 22 publications

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“…However, MRPS23 overexpression was found to promote hepatocellular carcinoma cell proliferation and suggested a low survival rate in hepatocellular carcinoma patients [ 77 ]. Similar to MRPS23, the increase of MRPS18-A can promote the development of liver cancer [ 60 ]. According to the Pearson correlation analysis of the construction module and clinical traits, gene MRPS18-A affects not only the liver function but also the overall survival of patients with cholangiocarcinoma [ 61 ].…”

Section: Mrps Associated With Cancersmentioning

confidence: 99%

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Huang

Zhang

2020

IJMS

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Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes, all of which play roles in the mitochondrial respiratory chain. After a long period of reconstruction, mitochondrial ribosomes are the most protein-rich ribosomes. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes, synthesized in the cytoplasm and then, transported to the mitochondria to be assembled into mitochondrial ribosomes. MRPs not only play a role in mitochondrial oxidative phosphorylation (OXPHOS). Moreover, they participate in the regulation of cell state as apoptosis inducing factors. Abnormal expressions of MRPs will lead to mitochondrial metabolism disorder, cell dysfunction, etc. Many researches have demonstrated the abnormal expression of MRPs in various tumors. This paper reviews the basic structure of mitochondrial ribosome, focuses on the structure and function of MRPs, and their relationships with cell apoptosis and diseases. It provides a reference for the study of the function of MRPs and the disease diagnosis and treatment.

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Section: Mrps Associated With Cancersmentioning

confidence: 99%

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Huang

Zhang

2020

IJMS

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“…By searching related literature and databases, about 30% lncRNAs have been verified to play roles in the regulation of proliferation, invasion, and migration of ovarian cancer cells, including ZFAS1, SNHG1, GAS5, EMX20S, GIHCG, TP53TG1, EPB41L4A-AS1, SNHG8, SNHG6 , and HCP5 (Zhan et al, 2018 ; Gao et al, 2019 ; Wu et al, 2019 ; Miao et al, 2020 ; Wang et al, 2020 ). In addition, some lncRNAs (e.g., SNHG29, FGD5-AS1, TRIM52-AS1, EPB41L4A-AS1, RNASEH1-AS1, SNHG7, SPINT1-AS1, MAPKAPK5-AS1 , and PITPNA-AS1 ) are reported to be involved in other types of cancers (Wang et al, 2018 ; Gao et al, 2019 , 2; Han et al, 2019 ; Zhou et al, 2020 ). Through retrieving the miRCancer database (version june2020) (Xie et al, 2013 ), 60.5% miRNAs in the competing triplets have been proved to be associated with ovarian cancer.…”

Section: Resultsmentioning

confidence: 99%

Identification of Potential Prognostic Competing Triplets in High-Grade Serous Ovarian Cancer

Zhao

Song

et al. 2021

Front. Genet.

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Increasing lncRNA-associated competing triplets were found to play important roles in cancers. With the accumulation of high-throughput sequencing data in public databases, the size of available tumor samples is becoming larger and larger, which introduces new challenges to identify competing triplets. Here, we developed a novel method, called LncMiM, to detect the lncRNA–miRNA–mRNA competing triplets in ovarian cancer with tumor samples from the TCGA database. In LncMiM, non-linear correlation analysis is used to cover the problem of weak correlations between miRNA–target pairs, which is mainly due to the difference in the magnitude of the expression level. In addition, besides the miRNA, the impact of lncRNA and mRNA on the interactions in triplets is also considered to improve the identification sensitivity of LncMiM without reducing its accuracy. By using LncMiM, a total of 847 lncRNA-associated competing triplets were found. All the competing triplets form a miRNA–lncRNA pair centered regulatory network, in which ZFAS1, SNHG29, GAS5, AC112491.1, and AC099850.4 are the top five lncRNAs with most connections. The results of biological process and KEGG pathway enrichment analysis indicates that the competing triplets are mainly associated with cell division, cell proliferation, cell cycle, oocyte meiosis, oxidative phosphorylation, ribosome, and p53 signaling pathway. Through survival analysis, 107 potential prognostic biomarkers are found in the competing triplets, including FGD5-AS1, HCP5, HMGN4, TACC3, and so on. LncMiM is available at https://github.com/xiaofengsong/LncMiM.

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“… 36 In previous study, Zhou et al found that TRIM52-AS1 could sponge miR-514a-5p to promote HCC progression through increasing MRPS18A. 37 And they firstly discussed the effect of lncRNA TRIM52-AS1 on proliferation and migration in HCC cells. The underlying mechanism was that TRIM52-AS1 upregulated MRPS18A expression by competitive binding miR-514a-5p.…”

Section: Discussionmentioning

confidence: 99%

Long Non-Coding RNA TRIM52-AS1 Promotes Growth and Metastasis via miR-218-5p/ROBO1 in Hepatocellular Carcinoma

Liu

et al. 2021

CMAR

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Background: Hepatocellular carcinoma (HCC) is a malignant disease with a high mortality among primary HCC patients worldwide. Lots of studies have shown that lncRNAs are known as the biomarkers in diagnosis, treatment and prognosis of hepatocellular carcinoma. Therefore, clarifying the detailed function and mechanism of the lncRNA in the HCC progressing seems particularly important. Methods: The TCGA and GEO database and RT-qPCR were used to analyse the expression of TRIM52-AS1 in HCC tissues and cell lines. Clinical data were collected to further analyze the correlation between indicators of clinical samples and the expression of TRIM52-AS1. CCK-8, plate clone and transwell assays were employed to evaluate the role of TRIM52-AS1 on cell proliferation, migration and invasion. Then, bioinformatics prediction, luciferase reporter, RNA immunoprecipitation (RIP), and RT-qPCR were employed to analyze the direct interaction among TRIM52-AS1, miR-218-5p and ROBO1. Additionally, the rescue function assays were used to verify that miR-218-5p/ROBO1 was the function downstream of TRIM52-AS1. Results: TRIM52-AS1 was overexpressed in HCC according to the TCGA database and RT-qPCR assay. The expression of TRIM52-AS1 was higher in the metastatic foci compared with primary tumor according to the GEO database. Additionally, TRIM52-AS1 knockdown inhibited the proliferation and metastasis of HCC cells. TRIM52-AS1 could act as competitive endogenous RNA to regulate ROBO1 through miR-218-5p, then promoted the HCC cell progression. Conclusion: TRIM52-AS1 is overexpressed in HCC and can promote the proliferation and metastasis of HCC cells through miR-218-5p/ROBO1 axis, then drives the HCC cell progression.

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Long Noncoding RNA TRIM52-AS1 Sponges miR-514a-5p to Facilitate Hepatocellular Carcinoma Progression Through Increasing MRPS18A

Cited by 17 publications

References 22 publications

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Identification of Potential Prognostic Competing Triplets in High-Grade Serous Ovarian Cancer

Long Non-Coding RNA TRIM52-AS1 Promotes Growth and Metastasis via miR-218-5p/ROBO1 in Hepatocellular Carcinoma

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