Long noncoding RNA SNHG6 regulates p21 expression via activation of the JNK pathway and regulation of EZH2 in gastric cancer cells

Li, Yan; Li, Dongdong; Zhao, Mei; Huang, Shiang Suo; Zhang, Qiao; Lin, Hong; Wang, Wenjie; Li, Kexin; Li, Zihao; Huang, Weiyan; Che, Yi-Qun; Huang, Changzhi

doi:10.1016/j.lfs.2018.07.032

Cited by 49 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, although these techniques quantify these transcripts, only a few have been shown to be involved in regulating a diverse array of biological processes . This study demonstrated the roles of SNHG6, whose functions in other cancers have been suggested in previous studies . For example, Chang et al reported that SNHG6 promotes tumour growth and metastasis by inducing EMT in hepatocellular carcinoma .…”

Section: Discussionsupporting

confidence: 67%

Long non‐coding RNA SNHG6 promotes cell proliferation and migration through sponging miR‐4465 in ovarian clear cell carcinoma

Deng

Guo

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Dysregulation of small nucleolar RNA host gene 6 (SNHG6) exerts critical oncogenic effects and facilitates tumourigenesis in human cancers. However, little information about the expression pattern of SNHG6 in ovarian clear cell carcinoma (OCCC) is available, and the contributions of this long non‐coding RNA to the tumourigenesis and progression of OCCC are unclear. In the present study, we showed via quantitative real‐time PCR that SNHG6 expression was abnormally up‐regulated in OCCC tissues relative to that in unpaired normal ovarian tissues. High SNHG6 expression was correlated with vascular invasion, distant metastasis and poor survival. Further functional experiments demonstrated that knockdown of SNHG6 in OCCC cells inhibited cell proliferation, migration and invasion in vitro as well as tumour growth in vivo. Moreover, SNHG6 functioned as a competing endogenous RNA (ceRNA), effectively acting as a sponge for miR‐4465 and thereby modulating the expression of enhancer of zeste homolog 2 (EZH2). Taken together, our data suggest that SNHG6 is a novel molecule involved in OCCC progression and that targeting the ceRNA network involving SNHG6 may be a treatment strategy in OCCC.

show abstract

Section: Discussionsupporting

confidence: 67%

Long non‐coding RNA SNHG6 promotes cell proliferation and migration through sponging miR‐4465 in ovarian clear cell carcinoma

Deng

Guo

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…In gastric cancer, SNHG6 was significantly highly expressed in gastric cancer tissues and in serum . Yan K et al suggested that high expression of SNHG6 was related to the tumor grade and lymph node metastasis, which predicted a poor prognosis for patients .…”

Section: Biological Functions and Mechanisms Of Snhgs In Digestive Camentioning

confidence: 99%

“…69 In gastric cancer, SNHG6 was significantly highly expressed in gastric cancer tissues and in serum. 70,71 Yan K et al suggested that high expression of SNHG6 was related to the tumor grade and lymph node metastasis, which predicted a poor prognosis for patients. 70 Yan et al and Li et al both proposed that SNHG6 existed not only in the cytoplasm but also in the nucleus, and the proportion in the cytoplasm was nearly 67.5%-80%.…”

Section: Snhgs In Gastric Cancermentioning

confidence: 99%

“…Reduced SNHG6 enhanced the expression of CDKN1A via the JNK signaling pathway to participate in tumor growth. 71 Down-regulated SNHG7 could arrest gastric cancer cell cycle progression in the G0-G1 period probably because it augmented the expression of CDKN2B and CDKN2A. 72 Yang et al and Zhang et al raised the idea that not only SNHG12 accelerated gastric cancer cell proliferation and invasion, but it also determined the adverse events prediction.…”

Section: Snhgs In Gastric Cancermentioning

confidence: 99%

See 1 more Smart Citation

Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

View full text Add to dashboard Cite

Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital in nearly every aspect of tumor biology. Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs) are abnormally expressed in multiple cancers, including urologic neoplasms, respiratory tumors, and digestive cancers, and play vital roles in these cancers. These host genes could participate in tumorigenesis by regulating proliferation, migration, invasion and apoptosis of tumor cells. This review focuses on the overview of the roles that lnc‐SNHGs play in the formation and progression of digestive cancers.

show abstract

“…Small nucleolar RNA host gene 6 (SNHG6) is a long non‐coding RNA (lncRNA) which plays a critical role in cancer progression. Increasing data have indicated that the elevated expression of SNHG6 is a poor prognostic factor in esophageal squamous cell carcinoma (ESCC), facilitates the cycle progression in breast cancer and promotes cell proliferation and invasion in colorectal cancer (CRC), osteosarcoma, gastric cancer and hepatocellular carcinoma (HCC) . These studies suggest that SNHG6 may be a prognostic factor for cancer.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA SNHG6 promotes the growth and invasion of non‐small cell lung cancer by downregulating miR‐101‐3p

Jiang

Xiang

et al. 2020

Thoracic Cancer

View full text Add to dashboard Cite

Background: The aim of this study was to determine the function of long noncoding RNA small nucleolar RNA host gene 6 (SNHG6) in non-small cell lung cancer (NSCLC) and its underlying mechanisms. Methods: The association of SNHG6 or miR-101-3p with clinicopathological characteristics and prognosis in patents with NSCLC was assessed by TCGA dataset. Cell proliferation and invasion were evaluated by MTT and Transwell assays and SNHG6-specific binding with miR-101-3p was verified by bioinformatic analysis, luciferase gene report and RNA immunoprecipitation assays. qRT-PCR and Western blot was used to assess the effects of SNHG6 on the expression of miR-101-3p and chromodomain Y like (CDYL) in NSCLC cells. A xenograft tumor model in vivo was established to observe the effects of SNHG6 knockdown on tumor growth. Results: We found that increased expression of SNHG6 was associated with pathological stage and lymph node infiltration, and acted as an independent prognostic factor of tumor recurrence in patients with NSCLC. Silencing SNHG6 expression repressed cell growth and invasion in vitro and in vivo, but overexpression of SNHG6 reversed these effects. Furthermore, SNHG6 was identified to act as a sponge of miR-101-3p, which could reduce cell proliferation and attenuate SNHG6-induced CDYL expression. Low expression of miR-101-3p or high expression of CDYL was related to poor survival in patients with NSCLC. Conclusions: Our findings demonstrated that lncRNA SNHG6 contributed to the proliferation and invasion of NSCLC by downregulating miR-101-3p.

show abstract

Long noncoding RNA SNHG6 regulates p21 expression via activation of the JNK pathway and regulation of EZH2 in gastric cancer cells

Cited by 49 publications

References 34 publications

Long non‐coding RNA SNHG6 promotes cell proliferation and migration through sponging miR‐4465 in ovarian clear cell carcinoma

Long non‐coding RNA SNHG6 promotes cell proliferation and migration through sponging miR‐4465 in ovarian clear cell carcinoma

Long non‐coding small nucleolar RNA host genes in digestive cancers

Long non‐coding RNA SNHG6 promotes the growth and invasion of non‐small cell lung cancer by downregulating miR‐101‐3p

Contact Info

Product

Resources

About