Long noncoding RNA SNHG17: a novel molecule in human cancers

Ma, Li; Gao, Jin; Zhang, Niu; Wang, Jiawei; Xu, Tianwei; Lei, Tianyao; Zou, Xiaoteng; Wei, Chenchen; Wang, Zhaoxia

doi:10.1186/s12935-022-02529-7

Cited by 15 publications

(12 citation statements)

References 92 publications

(104 reference statements)

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“…There is a category of lncRNAs that are both regulated by MYC and required to sustain MYC-driven cell proliferation. Examples of these long non-coding transcripts are SNHG17 [ 37 ], SNAI3-AS1 [ 68 ], MIR17HG [ 69 ], SNHG26 [ 38 ], SNHG5 [ 70 , 71 ], and numerous others [ 32 ]. All of these also exert a pro-growth effect on the cell.…”

Section: Discussionmentioning

confidence: 99%

“…Building on these results, we developed a new CRISPRi approach and identified MYC-regulated lncRNAs that are required for cell proliferation in human B cells [ 32 ]. Several of the top candidates of this CRISPRi screen are known for their involvement in cancer including DANCR [ 33 – 35 ], MIR17HG [ 36 ], SNHG17 [ 37 ] and SNHG26 [ 38 , 39 ]. Here, we have analyzed the function of the transcript ENSG00000254887, referred to as LNROP (long non-coding regulator of POU2F2), which was also identified in the previous CRISPRi screen as indispensable for B cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

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The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2

2023

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MYC controls most of the non-coding genome. Several long noncoding transcripts were originally identified in the human B cell line P496-3 and then shown to be required for MYC-driven proliferation of Burkitt lymphoma-derived RAMOS cells. In this study, we used RAMOS cells exclusively as a representative of the human B cell lineage. One of the MYC-controlled lncRNAs required for RAMOS cell proliferation is ENSG00000254887 which we will term LNROP (long non-coding regulator of POU2F2). In the genome, LNROP is located in close proximity of POU2F2, the gene encoding OCT2. OCT2 is a transcription factor with important roles in sustaining the proliferation of human B cells. Here we show that LNROP is a nuclear RNA and a direct target of MYC. Downregulation of LNROP attenuates the expression of OCT2. This effect of LNROP on the expression of OCT2 is unidirectional as downregulation of OCT2 does not alter the expression of LNROP. Our data suggest that LNROP is a cis-acting regulator of OCT2. To illustrate the downstream reach of LNROP, we chose a prominent target of OCT2, the tyrosine phosphatase SHP-1. Downregulation of OCT2 elevates the expression of SHP-1. Our data suggest the following path of interactions: LNROP enables the proliferation of B cells by positively and unidirectionally regulating the growth-stimulatory transcription factor OCT2. In actively proliferating B cells, OCT2 attenuates the expression and anti-proliferative activity of SHP-1.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2

2023

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“…Upon to SNHG17, it has been identified as a novel long-coding RNA, referring to oncogenic function in various cancers[ 7 ]. SNHG17 has high expression in many cancer tissues and can be induced by many factors including m6A methyltransferase METTL3 [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…They found SNHG17 is highly overexpression in colorectal cancer, promoted cancer cell proliferation and is an unfavorable prognostic factor [ 6 ]. A recent review summarized SNHG17 is a novel cancer-related lncRNA which is highly overexpression in various cancers exerting oncogenic functions [ 7 ]. SNHG17 is also an EMT-related lncRNA with the evidence that TGF-beta1 activates SNHG17 expression, promoting cancer cells EMT, leading to the facilitation of esophageal squamous cell growth [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation

Zhao

Pan

et al. 2023

Biol Direct

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Radiation-induced pulmonary fibrosis (RIPF) is a major side effect experienced for patients with thoracic cancers after radiotherapy. RIPF is poor prognosis and limited therapeutic options available in clinic. Lactobacillus rhamnosus GG (LGG) is advantaged and widely used for health promotion. However. Whether LGG is applicable for prevention of RIPF and relative underlying mechanism is poorly understood. Here, we reported a unique comprehensive analysis of the impact of LGG and its’ derived lncRNA SNHG17 on radiation-induced epithelial–mesenchymal transition (EMT) in vitro and RIPF in vivo. As revealed by high-throughput sequencing, SNHG17 expression was decreased by LGG treatment in A549 cells post radiation and markedly attenuated the radiation-induced EMT progression (p < 0.01). SNHG17 overexpression correlated with poor overall survival in patients with lung cancer. Mechanistically, SNHG17 can stabilize PTBP1 expression through binding to its 3′UTR, whereas the activated PTBP1 can bind with the NICD part of Notch1 to upregulate Notch1 expression and aggravated EMT and lung fibrosis post radiation. However, SNHG17 knockdown inhibited PTBP1 and Notch1 expression and produced the opposite results. Notably, A549 cells treated with LGG also promoted cell apoptosis and increased cell G2/M arrest post radiation. Mice of RIPF treated with LGG decreased SNHG17 expression and attenuated lung fibrosis. Altogether, these data reveal that modulation of radiation-induced EMT and lung fibrosis by treatment with LGG associates with a decrease in SNHG17 expression and the inhibition of SNHG17/PTBP1/Nothch1 axis. Collectively, our results indicate that LGG exerts protective effects in RIPF and SNHG17 holds a potential marker of RIPF recovery in patients with thoracic cancers.

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“…[3][4][5][6] Long noncoding RNA (lncRNA) refers to a class of regulator RNA longer than 200 nucleotides in length without the capacity of encoding proteins. [7] It has been proved that lncRNAs played important roles in the tumor genesis, invasion, and metastasis of human cancers, [8][9][10] including HCC. [11][12][13] Several lncRNAs have been identified to serve as the prognostic indicators for HCC, such as TUG1, [12] LINC01234, [11] and SNHG5.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of long noncoding RNA HOTAIR in hepatocellular carcinoma: A protocol for systematic review and meta-analysis

Feng

Liu

et al. 2022

Medicine

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Background: Homeobox transcript antisense intergenic RNA (HOTAIR), a long noncoding RNA, has been reported to associate with the prognosis of patients with hepatocellular carcinoma (HCC) in several studies, however, the definite conclusion has not been obtained for conflicting results across different studies. The aim of this study is to determine the association of HOTAIR expression with overall survival, progression-free survival, and clinical features in HCC.Methods: PubMed, Cochrane Library, and Embase will be comprehensively searched to seek the relevant studies. The studies meeting the inclusion criteria will be included into this systematic review and meta-analysis. A combination of hazard ratio and 95% confidence interval is used to estimate the impact of HOTAIR expression on the overall survival and progression-free survival in HCC. The relationship between HOTAIR expression and clinical features of HCC is evaluated using the odds ratio and 95% confidence interval. The study quality is evaluated with the "risk of bias assessment" tool in Cochrane System Assessment Manual or Newcastle-Ottawa Scale. The subgroup analysis, publication bias, and sensitivity analysis are performed.Results: This study provides a strict and classic protocol for systematic review and meta-analysis to determine the prognostic significance of HOTAIR expression in HCC. The findings of this systematic review and meta-analysis may provide a novel diagnostic indicator and potential therapeutic target of HCC.Ethics and dissemination: This study is only a protocol for systematic review and meta-analysis, and all data used in this study is acquired through published studies. Therefore, the ethical review is not needed for this study.

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Long noncoding RNA SNHG17: a novel molecule in human cancers

Cited by 15 publications

References 92 publications

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2

Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation

Prognostic significance of long noncoding RNA HOTAIR in hepatocellular carcinoma: A protocol for systematic review and meta-analysis

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