Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p

Zhang, Longyu; Wei, Zhaolian; Wang, Ying; Xu, Fuxia; Cheng, Zhongyu

doi:10.1080/10799893.2020.1836495

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…Highly expressed ROR1-AS1 (Receptor tyrosine kinase-like orphan receptor 1-antisense RNA 1) was observed to enhance the growth as well as autophagy in cervical cancer cells via ROR1-AS1/miR-670-3p/STC2 (Stanniocalcin 2) axis. The opposite effects on the cell growth and autophagy were observed with the silencing of ROR1-AS1 that ultimately inhibited the malignant characteristics of cervical cancer cells [ 191 ]. LncRNA IGFBP4 (Insulin-like growth factor binding protein 4) is negatively controlled by c-Myc, which has a remarkable role in the cell autophagy response.…”

Section: Lncrnas As Clinical Utility Targetsmentioning

confidence: 99%

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

et al. 2023

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Cervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures, and chemoradiation therapy, cervical cancer remains the most commonly diagnosed cancer in 23 countries and the leading cause of cancer deaths in 36 countries. There is, therefore, a need to come up with novel diagnostic and therapeutic targets. Long non-coding RNAs (lncRNAs) play a remarkable role in genome regulation and contribute significantly to several developmental and disease pathways. The deregulation of lncRNAs is often observed in cancer patients, where they are shown to affect multiple cellular processes, including cell cycle, apoptosis, angiogenesis, and invasion. Many lncRNAs are found to be involved in the pathogenesis as well as progression of cervical cancer and have shown potency to track metastatic events. This review provides an overview of lncRNA mediated regulation of cervical carcinogenesis and highlights their potential as diagnostic and prognostic biomarkers as well as therapeutic targets for cervical cancer. In addition, it also discusses the challenges associated with the clinical implication of lncRNAs in cervical cancer.

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Section: Lncrnas As Clinical Utility Targetsmentioning

confidence: 99%

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

et al. 2023

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“…Consistently, lncRNA homeobox transcript antisense RNA (HOTAIR) is overexpressed in human HNSCC samples, and it can also promote STC2 expression through functioning as a sponge of miR-206 [ 147 ]. In addition, other two lncRNAs are reported to regulate STC2 expression, for example, ROR1-AS1 functions to sponge miR-670-3p that suppresses STC2 expression in cervical cancer [ 148 ]; SNHG17 promotes STC2 expression through antagonizing the activity of miR-361-3p in rectal cancer [ 149 ].…”

Section: Introductionmentioning

confidence: 99%

Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target

Qie

Sang

2022

J Exp Clin Cancer Res

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Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of tumour cells and tumour tissues derived from human breast, colorectum, stomach, esophagus, prostate, kidney, liver, bone, ovary, lung and so forth. The expression of STC2 is regulated at both transcriptional and post-transcriptional levels; particularly, STC2 is significantly stimulated under various stress conditions like ER stress, hypoxia and nutrient deprivation. Biologically, STC2 facilitates cells dealing with stress conditions and prevents apoptosis. Importantly, STC2 also promotes the development of acquired resistance to chemo- and radio- therapies. In addition, multiple groups have reported that STC2 overexpression promotes cell proliferation, migration and immune response. Therefore, the overexpression of STC2 is positively correlated with tumour growth, invasion, metastasis and patients’ prognosis, highlighting its potential as a biomarker and a therapeutic target. This review focuses on discussing the regulation, biological functions and clinical importance of STC2 in human cancers. Future perspectives in this field will also be discussed.

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lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis

Fang

Zhang

et al. 2022

Appl Biochem Biotechnol

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Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p

Cited by 8 publications

References 33 publications

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target

lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis

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