Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner

Li, Juexing; Zhou, Lei; Jiang, Yuanliang; Gao, Hailan; Maierhaba, Tuersuntuoheti; Gong, Hui

doi:10.1016/j.mcp.2023.101937

“…In conclusion, morphological and functional defects of the heart in doxorubicin-induced cardiotoxicity are similar to those of DCM [19,20]. Meanwhile, according to the previous study [21], the HL-1 and AC16 cells were respectively administrated with Dox (0.5µmol/L) for 24 h. As shown in Fig. 2F-2H, we found that doxorubicin administration promoted the enlargement of cardiac cells and enhanced the mRNA levels of cardiac hypertrophic genes.…”

Section: Doxorubicin-induced Cardiotoxicity In Vitro and In Vivo Modelsupporting

confidence: 68%

TGFB2-AS1 binding to MED1 promotes doxorubicin-induced cardiomyocyte apoptosis via BMP7 pathway

Gao

¹

,

Lan

²

,

Peng

³

et al. 2024

Preprint

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Wang et al observed that knockdown of SOX2-OT downregulated DP5 via sponging miR-942-5p and inhibiting DOX-induced apoptosis in primary cardiomyocytes [ 83 ]. Gong et al showed that overexpression of lncRNA RMRP could inhibit the expression of p53 and its phosphorylation level by suppressing profilin 1 (PFN1) to exert cardioprotective effects, holding great promise for serving as a therapeutic target and potential biomarker of DIC [ 86 ]. In the DIC in vitro model, DOX treatment resulted in the upregulation of methyltransferase-like 14 (METTL14), which catalyzed the m6A modification of lncRNA KCNQ1OT1, a miR-7-5p sponge [ 79 ].…”

Section: Non-coding Rnas Involved In the Dicmentioning

confidence: 99%

Non-Coding RNAs in the Regulation of Doxorubicin-Induced Cardiotoxicity

Sun

¹

,

Kim

²

,

Yang

³

2025

Biomolecules

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity

Pan

¹

,

Yang

²

,

Zang

³

et al. 2024

Mol Cell Biochem

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner

Cited by 4 publications

References 40 publications

TGFB2-AS1 binding to MED1 promotes doxorubicin-induced cardiomyocyte apoptosis via BMP7 pathway

TGFB2-AS1 binding to MED1 promotes doxorubicin-induced cardiomyocyte apoptosis via BMP7 pathway

Non-Coding RNAs in the Regulation of Doxorubicin-Induced Cardiotoxicity

Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity

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