2018
DOI: 10.1261/rna.065524.118
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Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast

Abstract: Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides but often unstable, contribute a substantial and diverse portion to pervasive noncoding transcriptomes. Most lncRNAs are poorly annotated and understood, although several play important roles in gene regulation and diseases. Here we systematically uncover and analyze lncRNAs in Based on RNA-seq data from twelve RNA-processing mutants and nine physiological conditions, we identify 5775 novel lncRNAs, nearly 4× the previously annotated lncRNAs.… Show more

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Cited by 51 publications
(92 citation statements)
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References 133 publications
(242 reference statements)
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“…As previously reported in S. cerevisiae and S. pombe (Wery et al 2016;Atkinson et al 2018;Wery et al 2018b), many lncRNAs are targeted by both Rrp6 and Xrn1 in N. castellii ( Figure 1B).…”
Section: Aslncrnas Are Primarily Degraded By Rrp6 and Xrn1 In N Castsupporting
confidence: 84%
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“…As previously reported in S. cerevisiae and S. pombe (Wery et al 2016;Atkinson et al 2018;Wery et al 2018b), many lncRNAs are targeted by both Rrp6 and Xrn1 in N. castellii ( Figure 1B).…”
Section: Aslncrnas Are Primarily Degraded By Rrp6 and Xrn1 In N Castsupporting
confidence: 84%
“…Only 10 DUTs accumulate in dcr1 cells, and they are also (even more) sensitive to Xrn1 ( Figure S1D). This is marginal in comparison to the 1392 DUTs annotated in fission yeast (Atkinson et al 2018), raising the question of the function of Dcr1 in N. castellii. DCR1 has been conserved in some budding yeast species (Drinnenberg et al 2009).…”
Section: Discussionmentioning
confidence: 95%
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“…represents sense transcripts, as antisense transcripts of the H3.c1 gene was~1% of sense transcripts 16 .…”
Section: Resultsmentioning
confidence: 99%