Long noncoding RNA PTPRG‐AS1 acts as a microRNA‐194‐3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1

Liang, Yi; Ouyang, Liang; Wang, Shuang; Li, Shi-Sheng; Yang, Xinming

doi:10.1002/jcp.28547

Cited by 53 publications

(53 citation statements)

References 39 publications

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“…It has been described with several studies that alteration of gene expression in particular genes may affect the NPC tumor behavior, including proliferation capacity, apoptosis of affected cells, and cellular invasion and metastasis [21,22,23]. This result is consistent with association of invasion of tumoral cell and metastasis with abnormal cell adhesion and endodermal cell proliferation and division of nucleus [24].…”

Section: Plos Onesupporting

confidence: 80%

DNA methylation biomarkers for nasopharyngeal carcinoma

et al. 2020

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Background Aberrant methylation of DNA plays an important role in the pathogenesis of nasopharyngeal carcinoma (NPC). In the current study, we aimed to integrate three cohorts profile datasets to identify abnormally methylated-differentially expressed genes and pathways associated with NPC. Methods Data of gene expression microarrays (GSE53819, GSE412452) and gene methylation microarrays (GSE52068) obtained from the GEO database. Aberrantly methylated differentially expressed genes (DEGs) were obtained by GEO2R. The David database was utilized to perform enrichment and functional analysis regarding selected genes. To create a protein-protein interaction (PPI), STRING and Cytoscape software were utilized. The MCODE was used for module analysis of the PPI network. Results In total, 181 hypomethylation-high expression genes were identified, which were enriched in the biological mechanisms involved in the differentiation of endodermal cell, mitotic nuclear division, mitotic cell cycle process, chromosome segregation and cell cycle phase transition, etc. Pathway enrichment showed ECM-receptor interaction, PI3K-Akt signaling pathway, Focal adhesion, Protein digestion and absorption and Amoebiasis, etc. The top 3 hub genes of PPI network were FANCI, POSTN, and IFIH1. Additionally, 210 hypermethylation-low expression genes were identified, and our data revealed enrichment in biological processes including axoneme assembly, micro tubular formation, assembly of axonemal dynein

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Section: Plos Onesupporting

confidence: 80%

DNA methylation biomarkers for nasopharyngeal carcinoma

et al. 2020

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“…PTPRG-AS1 is overexpressed in breast cancer [22], nasopharyngeal carcinoma [23], and gastric cancer [24]. Highly expressed PTPRG-AS1 is correlated with poor survival for patients with gastric cancer [24].…”

Section: Discussionmentioning

confidence: 99%

“…Highly expressed PTPRG-AS1 is correlated with poor survival for patients with gastric cancer [24]. PTPRG-AS1 functions as a cancer-promoting lncRNA in nasopharyngeal carcinoma [23] and gastric cancer [24], and is implicated in the regulation of many types of malignant processes. However, the expression and function of PTPRG-AS1 in EOC has not been de ned.…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNA PTPRG-AS1 Promotes Cell Tumorigenicity in Epithelial Ovarian Cancer by Decoying microRNA-545-3p and Consequently Enhancing HDAC4 Expression

Shi

Zhang

et al. 2020

Preprint

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Background: Long non-coding RNA PTPRG antisense RNA 1 (PTPRG-AS1) deregulation has been reported in various human malignancies and identified as an important modulator of cancer development. Few reports have focused on the detailed role of PTPRG-AS1 in epithelial ovarian cancer (EOC) and its underlying mechanism. This study aimed to determine the physiological function of PTPRG-AS1 in EOC. A series of experiments were also done to identify the mechanisms through which PTPRG-AS1 exerts its function in EOC.Methods: Reverse transcription-quantitative polymerase chain reaction was used to determine PTPRG-AS1 expression in EOC tissues and cell lines. PTPRG-AS1 was silenced in EOC cells and studied with respect to cell proliferation, apoptosis, migration, invasion in vitro, and tumor growth in vivo. The putative miRNAs that target PTPRG-AS1 were predicted using bioinformatics analysis and further confirmed in luciferase reporter and RNA immunoprecipitation assays.Results: Our data verified the upregulation of PTPRG-AS1 in EOC tissues and cell lines. High PTPRG-AS1 expression was associated with shorter overall survival in patients with EOC. Functionally, EOC cell proliferation, migration, invasion in vitro and tumor growth in vivo were suppressed by PTPRG-AS1 silencing. In contrast, cell apoptosis was promoted by loss of PTPRG-AS1. For the mechanism part, PTPRG-AS1 could serve as a competing endogenous RNA in EOC cells by decoying microRNA-545-3p (miR-545-3p), thereby elevating histone deacetylase 4 (HDAC4) expression. Furthermore, rescue experiments revealed that PTPRG-AS1 knockdown-mediated effects on EOC cells were, in part, counteracted by the inhibition of miR-545-3p or restoration of HDAC4.Conclusions: PTPRG-AS1 functioned as an oncogenic lncRNA that aggravated the malignancy of EOC through the miR-545-3p/HDAC4 ceRNA network. Thus, targeting the PTPRG-AS1/miR-545-3p/HDAC4 pathway may be a novel strategy for EOC anticancer therapy.

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“…PTPRG-AS1 is correlated with ER+ and ER − subtypes, tumor grade, and clinical results [108]. It functions as a sponge of miR-194-3p to regulate the radio resistance and invasiveness in nasopharyngeal tumor cells through PRC1 [109]. ANRIL is an oncogenic lncRNA, which has a regulatory epigenetic role on p15/ CDKN2B-p16/CDKN2A-p14/ARF via recruitment of PRC2 and PRC1 [110].…”

Section: Breast Cancermentioning

confidence: 99%

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

2020

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Background: Cancer is associated with various genetic and environmental risk factors. Beside the mutations or aberrant expression of protein-coding genes, the genetic deregulation of non-coding RNAs has also an important role during tumor progression and metastasis. Long non-coding RNAs (lncRNAs) are a class of ncRNAs larger than 200 nucleotides that may function as tumor-suppressor or oncogene. Main body:There is a raising trend of cancer incidence among Iranian population during the last decades. Therefore, it is required to prepare a general population specific panel of genetic markers for the early detection of cancer in this population. The tissue-specific expression characteristics and high stability in body fluids highlight the lncRNAs as efficient diagnostic and prognostic noninvasive biomarkers in cancer. In present review we summarized all of the lncRNAs which have been reported until now in different tumors among Iranian patients. Conclusions:This review paves the way of introducing a population based noninvasive diagnostic panel of lncRNAs for the early detection of tumor cells among Iranian population.

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Long noncoding RNA PTPRG‐AS1 acts as a microRNA‐194‐3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1

Cited by 53 publications

References 39 publications

DNA methylation biomarkers for nasopharyngeal carcinoma

DNA methylation biomarkers for nasopharyngeal carcinoma

Long Non-coding RNA PTPRG-AS1 Promotes Cell Tumorigenicity in Epithelial Ovarian Cancer by Decoying microRNA-545-3p and Consequently Enhancing HDAC4 Expression

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

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