Long noncoding RNA: multiple players in gene expression

Chen, Xiaochang; Sun, Yunmei; Cai, Rui; Wang, Guoqiang; Shu, Xiaohong; Pang, Wei

doi:10.5483/bmbrep.2018.51.6.025

Cited by 67 publications

(51 citation statements)

References 91 publications

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“…Initially, lncRNAs were considered "transcriptional noise" without any biological function [25]. Along with the increasing research investigating lncRNAs, a growing body of evidence suggests that lncRNAs play important regulatory roles in various physiological activities [26,27]. However, due to a lack of corresponding databases, current methods, such as the analysis of sequence characteristics, molecular free energy, or secondary structure, for predicting the specific functions of lncRNA genes are still imperfect, and the biological functions of the majority of lncRNAs remain vague.…”

Section: Discussionmentioning

confidence: 99%

Genome‑wide integrated analysis demonstrates widespread functions of lncRNAs in mammary gland development and lactation in dairy goats

Chao

Liu

et al. 2020

BMC Genomics

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Background: The mammary gland is a unique organ for milk synthesis, secretion and storage, and it undergoes cyclical processes of development, differentiation, lactation and degeneration. At different developmental periods, the biological processes governing mammary gland physiology and internal environmental homeostasis depend on a complex network of genes and regulatory factors. Emerging evidence indicates that lncRNAs have arbitrarily critical functions in regulating gene expression in many organisms; however, the systematic characteristics, expression, and regulatory roles of lncRNAs in the mammary gland tissues of dairy goats have not been determined. Result: In the present study, we profiled long noncoding RNA (lncRNA) expression in the mammary gland tissues of Laoshan dairy goats (Capra hircus) from different lactation periods at the whole-genome level, to identify, characterize and explore the regulatory functions of lncRNAs. A total of 37,249 transcripts were obtained, of which 2381 lncRNAs and 37,249 mRNAs were identified, 22,488 transcripts, including 800 noncoding transcripts and 21,688 coding transcripts, differed significantly (p ≤ 0.01) among the different lactation stages. The results of lncRNA-RNA interaction analysis showed that six known lncRNAs belonging to four families were identified as the precursors of 67 known microRNAs; 1478 and 573 mRNAs were predicted as hypothetical cis-regulation elements and antisense mRNAs, respectively. GO annotation and KEGG analysis indicated that the coexpressed mRNAs were largely enriched in biological processes related to such activities as metabolism, immune activation, and stress,., and most genes were involved in pathways related to such phenomena as inflammation, cancer, signal transduction, and metabolism. Conclusions: Our results clearly indicated that lncRNAs involved in responses to stimuli, multiorganism processes, development, reproductive processes and growth, are closely related to mammary gland development and lactation.

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Section: Discussionmentioning

confidence: 99%

Genome‑wide integrated analysis demonstrates widespread functions of lncRNAs in mammary gland development and lactation in dairy goats

Chao

Liu

et al. 2020

BMC Genomics

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“…LncRNAs are transcripts longer than 200 nucleotides, located within either the intergenic stretches or the overlapping antisense transcripts of protein coding genes. LncRNAs can regulate the expression of target genes by both transcriptional and post-transcriptional mechanisms [36]. It has been reported that LncRNAs are regulators of vascular function and their dysregulation contributes to cardiovascular diseases [37,38].…”

Section: Overview Of Epigenetic Mechanisms Of Gene Regulationmentioning

confidence: 99%

Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms

Stanzione

Cotugno

Bianchi

et al. 2020

Genes

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Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemic stroke. Importantly, since epigenetic modifications are reversible processes they could assist with the development of new therapeutic approaches for the treatment of human diseases. In the present review article, we aim to collect the most recent evidence concerning the impact of epigenetic modifications on the pathogenesis of ischemic stroke in both animal models and humans.

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“…Furthermore, HuR is highly rich in tumor tissues, and HuR target mRNAs can encode proteins that are associated with tumorigenesis, including cell proliferation and angiogenesis . Moreover, OIP5‐AS1 can suppress cell proliferation by reducing GAK levels …”

Section: Mechanisms Of Lncrnas In MMmentioning

confidence: 99%

“…69 Moreover, OIP5-AS1 can suppress cell proliferation by reducing GAK levels. 70 In MM, downregulated OIP5-AS1 can increase the level of miR-410. 71,72 It is well known that miR-410, which acts as an oncogene or tumor suppressor, is dysregulated in cancers.…”

Section: Oip5-as1mentioning

confidence: 99%

The role of long non‐coding RNAs in multiple myeloma

Cui

Song

Fang

2019

European J of Haematology

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Multiple myeloma (MM) is still an incurable disease, and its pathogenesis involves cytogenetics and epigenetics. In recent years, the roles of long non‐coding RNAs (lncRNAs) in MM have been deeply studied by scholars. LncRNAs are defined as a class of non‐protein‐coding transcripts greater than 200 nucleotides in length, which are involved in a large spectrum of biological processes, including proliferation, differentiation, apoptosis, invasion, and chromatin remodeling. However, little is known about the specific mechanisms of these lncRNAs. They can act as oncogenic and/or tumor‐suppressive factors in the development and progression of MM. But that how do they work remains unclear. In this review, the recent progress in the study of functional lncRNAs associated with MM was summarized and the present knowledge about their expression and roles was discussed, to provide guidance for the in‐depth functional study of lncRNAs.

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Long noncoding RNA: multiple players in gene expression

Cited by 67 publications

References 91 publications

Genome‑wide integrated analysis demonstrates widespread functions of lncRNAs in mammary gland development and lactation in dairy goats

Genome‑wide integrated analysis demonstrates widespread functions of lncRNAs in mammary gland development and lactation in dairy goats

Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms

The role of long non‐coding RNAs in multiple myeloma

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