Long noncoding RNA MCM3AP-AS1 promotes ovarian cancer cells progression by modulating miR-383/DDIT4 axis

Abstract

Long non-coding RNA (lncRNA) was recently reported to be implicated in cancer progression. However, the role of MCM3AP-AS1 in ovarian cancer (OC) remains undetected. In this study, MCM3AP-AS1 expression was elevated in OC tissues. High MCM3AP-AS1 expression was related to advanced tumor stage and poor survival. MCM3AP-AS1 knockdown inhibited OC cells proliferation, migration, invasion and EMT in vitro and suppressed primary tumor growth in vivo. Mechanically, MCM3AP-AS1 sponged miR-383 and upregulated the expression of DDIT4. In addition, the suppression of EMT induced by silencing of MCM3AP-AS1 involved with miR-383 inhibition. In sum, MCM3AP-AS1 promoted cell progression through regulating miR-383/DDIT4, which suggested a novel potential oncogenic target for OC.