Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1

Abstract

In recent years, long noncoding RNAs (lncRNAs) have been reported to have significant regulating effect in human cancer development. Previous studies suggested that dysregulation of lncRNA 441178 (LOC441178) is possibly associated with oral squamous cell carcinoma (OSCC). The postoperative survival time was significantly prolonged in the high-grade OSCC patients with high LOC441178 expression compared with those with low LOC441178 expression, which indicated that LOC441178 may act as a prognostic marker and as a potential tumor suppressor for OSCC. However, the biological molecular mechanisms behind these phenomena remain almost unknown. Here, our studies revealed that LOC441178 suppressed the invasion and migration of squamous carcinoma cells (SCCs). Furthermore, we found that rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) is one of the functionally relevant targets of LOC441178 in squamous cells, which is negatively correlated with LOC441178 in tumor tissues from OSCC patients. In conclusion, our findings demonstrated the inhibition effect of LOC441178 on tumor in OSCC and might have potential implications for OSCC gene therapy. In conclusion, these results suggest that LOC441178 could represent a prognostic indicator for OSCC and be a new target for the diagnosis and treatment of OSCC.

LncRNA HOXB‐AS1 promotes cell growth in multiple myeloma via FUT4 mRNA stability by ELAVL1

“…LncRNAs can modulate gene expression to influence the biological activities of carcinomas. 19,20 As FUT4 is an important oncogenic factor in the progression of human carcinomas, we first measured FUT4 expression in MM cells and discovered that FUT4 expression was lifted in MM cells and tissues compared to that in nPCs cells and nontumor tissues (Figure 2A and Figure S1F). In U266 and H929 cells, FUT4 expression was accordingly lowered with shHOXB-AS1#1 treatment ( Figure 2B).…”

TCGA based integrated genomic analyses of ceRNA network and novel subtypes revealing potential biomarkers for the prognosis and target therapy of tongue squamous cell carcinoma

“…The dysregulation of LINC02487, alternatively known as LOC441178, was detected by transcriptome analysis and verified by RT-PCR in OSCC [57]. Xu [58] et al found that LINC02487 could sponge coiled-coil-containing protein kinase 1 (ROCK1) in OSCC, and that OSCC patients with a high expression of LINC02487 would have a longer survival time, which was in accordance with our result and also suggested that LINC02487 could be a new therapeutic target and prognostic indicator for TSCC. To the best of our knowledge, no relevant studies found that LINC02028, LOC101927503, LOC349160 and LINC02560 existed in cancer.…”

Validation of the Chinese version of the low physical activity questionnaire (LoPAQ) with ActiGraph accelerometer in hemodialysis patients

“…In MHD patients, a low physical activity level is closely related to poor prognosis [ 4 ]. Several studies have confirmed the relationship between a low physical activity level and the increased risk of cardiovascular disease in MHD patients [ 5 , 6 ], which was the leading cause of morbidity and mortality in these patients [ 7 , 8 ].…”