Long noncoding RNA LINC01426 promotes the progression of lung adenocarcinoma via regulating miRNA-125a-5p/ casein kinase 2 alpha 1 axis

Zhu, Xiaoling; Zhao, Jianguo; Xu, Jun

doi:10.1080/21655979.2022.2044251

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…It is indicated that LINC01426 may serve as a tumor biomarker. Several previous reports demonstrated the functions of LINC01426 in lung cancer [ 14 – 17 ]. However, the underlying molecular mechanism of LINC01426 in lung adenocarcinoma still remains to be further explored.…”

Section: Introductionmentioning

confidence: 99%

LINC01426 Triggers Growth and Metastasis of Lung Adenocarcinoma as a Prognostic Indicator

Deng

Cai

Liu

et al. 2022

BioMed Research International

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The vital regulation of abnormally expressed lncRNAs in human cancers has been identified. This study is aimed at illustrating the role of LINC01426 in influencing malignant behaviors of lung adenocarcinoma (LUAD) and the possible mechanism. Differential expressions of LINC01426 in a downloaded profile containing LUAD and normal tissues were analyzed using Gene Expression Profiling Interactive Analysis (GEPIA) database and were reconfirmed in clinical samples collected in our hospital. In addition, LINC01426 level in lung carcinoma cell lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR) as well. The relationship between LINC01426 expression and the age, tumor node metastasis (TNM) staging, lymphatic metastasis, tumor differentiation, and overall survival of LUAD was analyzed. After intervening LINC01426 level in H1299 and PC9 cells, proliferative and metastatic changes were assessed by functional experiments. LINC01426 was upregulated in LUAD tissues and cell lines. Its level was closely linked to TNM staging, lymphatic metastasis, tumor differentiation, and overall survival of LUAD. Knockdown of LINC01426 suppressed proliferative and metastatic abilities in H1299 and PC9 cells. LINC01246 is upregulated in LUAD samples and predicts a poor prognosis. It drives malignant process of LUAD via stimulating proliferative and metastatic abilities.

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Section: Introductionmentioning

confidence: 99%

LINC01426 Triggers Growth and Metastasis of Lung Adenocarcinoma as a Prognostic Indicator

Deng

Cai

Liu

et al. 2022

BioMed Research International

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“…Interestingly, in our constructed 3-ferroptosis-related lncRNA signature, LINC01426 is an oncogene that has been validated by many cancer researchers. LINC01426 promotes the development of lung cancer ( Dai et al, 2020 ; Han et al, 2020 ; Liu et al, 2021 ; Zhu et al, 2022 ), clear cell renal cell carcinoma ( Jiang et al, 2021 ), and osteosarcoma ( Zhang et al, 2021 ). Furthermore, the role of LINC01426 in glioma has also received increasing attention, including sponging miR-345-3p and upregulating VAMP8 to promote glioblastoma ( Cao et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of ferroptosis-related lncRNA signatures as a novel prognostic model for glioma

Huang

Zhang²,

Gong³

et al. 2022

Front. Genet.

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Background: Ferroptosis is a newly discovered form of regulated cell death with distinct properties and recognizing functions involved in physical conditions or various diseases, including cancers. However, the relationship between gliomas and ferroptosis-related lncRNAs (FRLs) remains unclear.Methods: We collected a total of 1850 samples from The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEX) databases, including 698 tumor and 1,152 normal samples. A list of ferroptosis-related genes was downloaded from the Ferrdb website. Differentially expressed FRLs (DEFRLS) were analyzed using the “limma” package in R software. Subsequently, prognosis-related FRLs were obtained by univariate Cox analysis. Finally, a prognostic model based on the 3 FRLs was constructed using Cox regression analysis with the least absolute shrinkage and selection operator (LASSO) algorithm. The prognostic power of the model was assessed using receiver operating characteristic (ROC) curve analysis and Kaplan-Meier (K-M) survival curve analysis. In addition, we further explored the relationship of the immune landscape and somatic mutations to prognostic model characteristics. Finally, we validated the function of LINC01426 in vitro.Results: We successfully constructed a 3-FRLs signature and classified glioma patients into high-risk and low-risk groups based on the risk score calculated from this signature. Compared with traditional clinicopathological features [age, sex, grade, isocitrate dehydrogenase (IDH) status], the prognostic accuracy of this model is more stable and stronger. Additionally, the model had stable predictive power for overall survival over a 5-year period. In addition, we found significant differences between the two groups in cellular immunity, the numbers of many immune cells, including NK cells, CD4+, CD8+ T-cells, and macrophages, and the expression of many immune-related genes. Finally, the two groups were also significantly different at the level of somatic mutations, especially in glioma prognosis-related genes such as IDH1 and ATRX, with lower mutation rates in the high-risk group leading to poorer prognosis. Finally, we found that the ferroptosis process of glioma cells was inhibited after knocking down the expression of LINC01426.Conclusion: The proposed 3-FRL signature is a promising biomarker for predicting prognostic features in glioma patients.

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“…Zhu et al. ( 56 ) found that LINC01426 promotes the progression of lung adenocarcinoma via regulating miRNA-125a-5p/casein kinase 2 alpha 1 axis. Tang et al.…”

Section: The Regulation Of Signaling Pathway That Lncrna Participated...mentioning

confidence: 99%

Differential expression and clinical significance of long non-coding RNAs in the development and progression of lung adenocarcinoma

Wei,

Zhang,

Lin

et al. 2024

Front. Oncol.

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With the development of gene testing technology, we have found many different genes, and lncRNA is one of them. LncRNAs refer to a non-protein coding RNA molecule with a length of more than 200bp, which is one of the focuses of research on human malignant diseases such as LUAD. LncRNAs act as an oncogene or inhibitor to regulate the occurrence and progression of tumors. The differential expression of LncRNAs promotes or inhibits the progression of lung adenocarcinoma by affecting cell proliferation, metastasis, invasion, and apoptosis, thus affecting the prognosis and survival rate of patients. Therefore, LncRNAs can be used as a potential target for diagnosis and treatment of cancer. The early diagnosis of the disease was made through the detection of tumor markers. Because lung adenocarcinoma is not easy to diagnose in the early stage and tumor markers are easy to ignore, LncRNAs play an important role in the diagnosis and treatment of lung adenocarcinoma. The main purpose of this article is to summarize the known effects of LncRNAs on lung adenocarcinoma, the effect of differential expression of LncRNAs on the progression of lung adenocarcinoma, and related signal transduction pathways. And to provide a new idea for the future research of lung adenocarcinoma-related LncRNAs.

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Long noncoding RNA LINC01426 promotes the progression of lung adenocarcinoma via regulating miRNA-125a-5p/ casein kinase 2 alpha 1 axis

Cited by 6 publications

References 56 publications

LINC01426 Triggers Growth and Metastasis of Lung Adenocarcinoma as a Prognostic Indicator

LINC01426 Triggers Growth and Metastasis of Lung Adenocarcinoma as a Prognostic Indicator

Identification and validation of ferroptosis-related lncRNA signatures as a novel prognostic model for glioma

Differential expression and clinical significance of long non-coding RNAs in the development and progression of lung adenocarcinoma

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