Long noncoding RNA LINC00958 promotes the oral squamous cell carcinoma by sponging miR-185-5p/YWHAZ

Wang, Zongsheng; Zhu, Xuemei; Dong, Pengfei; Cai, Jun

doi:10.1016/j.lfs.2019.116782

Cited by 33 publications

(27 citation statements)

References 25 publications

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“…In conjunction with the TargetScan website, we also predicted that there was a targeting relationship among a variety of LINC00958 , miRNAs and mRNAs. For example, the adsorption of miR-185-5p, miR-625-5p/CPSF7 axis and miR-625-5p/LRRC8 axis have been confirmed, although the feasibility of the rest needs subsequent verification ( S2 Table ) [ 15 , 18 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study showed that LINC00958 is involved in the carcinogenesis of bladder cancer [12]. The high expression of LINC00958 has also been shown to promote the occurrence and development of certain cancers, including bladder cancer, oral cancer, pancreatic cancer, gastric cancer, cervical cancer and glioma [13][14][15][16][17][18]. However, the relevant mechanism of LINC00958 in EC, especially ESCC, has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

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LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells

et al. 2021

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Oesophageal cancer is one of the deadliest cancers in the world. Oesophageal squamous cell carcinoma (ESCC) is the most prevalent histological type of oesophageal cancer. Oesophageal cancer has a poor prognosis because of its invasiveness. Thus, it is especially important to seek effective treatment methods. Research indicates that long non-coding RNAs (lncRNAs) play a significant role in the occurrence and development of oesophageal cancer. The aim of this study was to describe the role of LINC00958 in ESCC. Bioinformatics and real-time quantitative polymerase chain reaction (RT-qPCR) methods were utilized to predict and verify the expression of LINC00958 in ESCC. Related functional experiments, including cell proliferation, migration and invasion, were performed. In addition, a western blot and a dual luciferase reporter gene experiment were used to study the detailed carcinogenic mechanism of LINC00958. The results indicated there was a high expression of LINC00958 in ESCC, which promoted proliferation, migration, invasion and Epithelial–Mesenchymal Transition (EMT) of ESCC cells, and this effect may be via regulating miR-510-5p.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells

et al. 2021

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“…The other lncRNAs associated with OPMDs is presented in table 2 [4,27,28,29]; and OSCC progression in relation to angiogenesis in table 3 [4,6,10,18,21,23,25,29], cell proliferation in table 4 [4,15,19,23,25,27,30,31,32], metastasis in table 5 [1,4,6,8,16,18,22,25,31,33,35], and chemoresistance in table 6 [4,13,29]. Decreased expression of lncRNA PTENP1 is observed in progressive OPMDs [5].…”

Section: D) Urothelial Cancer-associated 1-uca1mentioning

confidence: 99%

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Venugopal¹,

Bavle²,

Sudhakara³

et al. 2020

GJMR

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Non-coding ribonucleic acids (ncRNAs) are a class of RNA molecules that are transcribed but not translated into proteins, but they affect various cellular processes. Around 60% of genes in humans do not code proteins but regulate target gene expression. Presently, a lot of research is carried out on ncRNA involvement in oral squamous cell carcinoma (OSCC) and its precursor lesions termed as oral potentially malignant disorders (OPMDs). They are broadly classified as small ncRNAs (sncRNA) and long ncRNAs (lncRNA). sncRNAs are extensively studied, whereas the divulgence of lncRNAs in OSCCs needs more revelation, hence reviewed in the present article. LncRNAs have a base pair length of more than 200, can form complex structures and influence the gene expression in a multifaceted pattern that attracts interest.

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“…H19 facilitated TSCC migration and invasion by sponging miR-let-7 [11], and LncRNA KCNQ1OT1 regulated proliferation and cisplatin resistance in tongue cancer via miR-211-5p-mediated Ezrin/Fak/Src signaling [12]. It is reported that High expression of LINC00958 is associated with malignancy, proliferation, and poor prognosis in various cancers, such as oral squamous cell carcinoma, head and neck squamous cell carcinoma, and pancreatic cancer [13,14] [15,16]. A previous study has reported that miR-3064 could promote pancreatic cancer cell growth, invasion, and sphere formation by down-regulating the levels of PIP4K2B-a tumor suppressor [17].…”

Section: Introductionmentioning

confidence: 99%

LINC00958 promotes the proliferation of TSCC via miR-211-5p/CENPK axis and activating the JAK/STAT3 signaling pathway

Jia

Dao²,

Han

et al. 2021

Preprint

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Background: Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, the role of LINC00958 and its downstream mechanisms in TSCC is still unknown. Methods: The expression levels of LINC00958 in human TSCC tissues and adjacent normal tissues were detected. The effect of LINC00958 on TSCC cells proliferation and growth were assessed by CCK-8, colony formation, 5-Ethynyl-2’-deoxyuridline (EdU) assay, and flow cytometry assays in vitro and tumor xenograft model in vivo. Bioinformatics analysis was used to predict the target of LINC00958 in TSCC, which was verified by RNA immunoprecipitation and luciferase reporter assays. Results: We found LINC00958 was increased in TSCC tissues, and patients with high LINC00958 expression had a shorter overall survival. LINC00958 knockdown significantly decreased the growth rate of TSCC cells both in vitro and in vivo . In mechanism, LINC00958 acted as a competing endogenous RNA (ceRNA) by competitively sponging miR-211-5p. In addition, we identified centromere protein K (CENPK) as a direct target gene of miR-211-5p, which was higher in TSCC tissues than that in adjacent normal tissues. Up-regulated miR-211-5p or down-regulated CENPK could abolish LINC00958-induced proliferation promotion in TSCC cells. Conclusion: Furthermore, CENPK promoted the expression of oncogenic cell cycle regulators and activated the JAK/STAT3 signaling. Our findings suggest that LINC00958 is a potential prognostic biomarker in TSCC.

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Long noncoding RNA LINC00958 promotes the oral squamous cell carcinoma by sponging miR-185-5p/YWHAZ

Cited by 33 publications

References 25 publications

LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells

LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

LINC00958 promotes the proliferation of TSCC via miR-211-5p/CENPK axis and activating the JAK/STAT3 signaling pathway

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