Long noncoding RNA <i>LINC00346</i> promotes glioma cell migration, invasion and proliferation by up‐regulating ROCK1

Chen, Xin; Li, Deheng; Chen, Lei; Hao, Bin; Gao, Yang; Li, Liangdong; Zhou, Changshuai; He, Xiayun; Cao, Yiqun

doi:10.1111/jcmm.15899

Cited by 9 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FAM181A-AS1 was demonstrated that enhanced proliferation and survivability of glioma cells [ 39 ] (p2) . LINC00346 was confirmed to regulate glioma angiogenesis, migration, invasion, and proliferation [ 40 , 41 ]. The expression of LINC00461 was significantly increased in stem cell-like/anti-therapeutic GBM cells [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Prognostic Signature of Necroptosis-Related lncRNAs and Molecular Subtypes in Glioma

Zhang

Chen

Zhu

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Background. In tumor progression and epigenetic regulation, long non-coding RNA (lncRNA) and necroptosis are crucial regulators. However, in glioma microenvironment, the role of necroptosis-related lncRNAs (NRLs) remains unknown. Method. In this study, the RNA-seq and clinical annotation of glioma patients were analyzed using the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. To investigate prognosis and tumor microenvironment of NRLs in gliomas, we conducted a prediction model based on the training cohort. The accuracy of the model was verified in the verification cohort. Results. A signature composed of 13 NRLs was identified, and all glioma patients were divided into two groups. We found that each group has unique survival outcomes, biological behaviors, and immune infiltrating status. The necroptosis-related lncRNA signature (NRLS) model was found to be an independent risk factor in multivariate Cox analysis. Immunosuppressive microenvironment was positively correlated with the high-risk group. Due to significantly different IC50 between risk groups, NRLS could be used as a guide for chemotherapeutic treatment. Further, the entire cohort was divided into two clusters depending on NRLs. Consensus clustering method and the risk scoring system were basically similar. Survival probability was higher in Cluster 2, while Cluster 1 has stronger immunologic infiltration. Conclusion. The predictive signature could be a prognostic factor independently and serve to detect the role of NRLs in glioma immunotherapy response.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Prognostic Signature of Necroptosis-Related lncRNAs and Molecular Subtypes in Glioma

Zhang

Chen

Zhu

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…Specifically, downregulated MIAT (FC = 1.48, FDR = 0.05), MIR4697HG (FC = 1.68, FDR = 0.04), and LINC00342 (FC = 1.51, FDR = 0.03) have been reported in neurological diseases 21–23 . Meanwhile, the overexpressed LINC00346 (FC = 1.58, FDR = 0.04) and MEG3 (FC = 1.46, FDR = 0.05) are known to be upregulated in neurological diseases 24,25 . In particular, overexpression of VTRNA2‐1 (also called svtRNA2‐1a ; FC = 1.58, FDR = 0.03) has been reported to reduce neuron basal viability 26 .…”

Section: Resultsmentioning

confidence: 99%

Analysis of multi‐omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances

Koh

Kim

et al. 2021

Environmental Toxicology

View full text Add to dashboard Cite

Environmentally hazardous substances and exposure to these can cause various diseases. Volatile organic compounds can easily evaporate into the atmosphere, thereby exerting toxic effects through either the skin or respiratory tract exposures. Toluene, a neurotoxin, has been widely used in various industries. However, it has a detrimental effect on the nervous system (such as hallucinations or memory impairment), while data on the mechanism underlaying its harmful effects remain limited. Therefore, this study investigates the effect of toluene on the nervous system via epigenetic and genetic changes of toluene‐exposed individuals. We identified significant epigenetic changes and confirmed that the affected abnormally expressed genes negatively influenced the nervous system. In particular, we confirmed that the miR‐15 family, upregulated by toluene, downregulated ABL2, which could affect the R as signaling pathway resulting in neuronal structural abnormalities. Our study suggests that miR‐15a‐5p, miR‐15b‐5p, miR‐16‐5p, miR‐301a‐3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene.

show abstract

“…H19 was reported to be upregulated in high-grade glioma and facilitated the proliferation of diffuse intrinsic pontine glioma ( Roig-Carles et al, 2021 ). LINC00346 promotes cell migration, proliferation, and apoptosis by targeting ROCK1( Chen et al, 2020 ) and miR-128-3p/SZRD1 axis ( Geng et al, 2020 ) in glioma. Overexpression of LINC00475 was observed in hypoxic gliomas and silencing LINC00475 results in suppression of tumor proliferation, migration, as well as invasion ( Yu et al, 2020a ).…”

Section: Discussionmentioning

confidence: 99%

A Novel lncRNA Panel Related to Ferroptosis, Tumor Progression, and Microenvironment is a Robust Prognostic Indicator for Glioma Patients

Tian

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Objective: To establish a lncRNA panel related to ferroptosis, tumor progression, and microenvironment for prognostic estimation in patients with glioma.Methods: LncRNAs associated with tumor progression and microenvironment were screened via the weighted gene co-expression network analysis (WGCNA). Overlapped lncRNAs highlighted in WGCNA, related to ferroptosis, and incorporated in Chinese Glioma Genome Atlas (CGGA) were identified as hub lncRNAs. With expression profiles of the hub lncRNA, we conducted the least absolute shrinkage and selection operator (LASSO) regression and built a ferroptosis-related lncRNA signature to separate glioma patients with distinct survival outcomes. The lncRNA signature was validated in TCGA, the CGGA_693, and CGGA_325 cohorts using Kaplan-Meier survival analysis and ROC curves. The ferroptosis-related lncRNA panel was validated with 15 glioma samples using quantitative real-time PCR (qRT-PCR). Multivariate Cox regression was performed, and a nomogram was mapped and validated. Immune infiltration correlated to the signature was explored using TIMER and CIBERSORT algorithms.Results: The present study identified 30 hub lncRNAs related to ferroptosis, tumor progression, and microenvironment. With the 30 hub lncRNAs, we developed a lncRNA signature with distinct stratification of survival chance in patients with glioma in two independent cohorts (HRs>1, p < 0.05). The lncRNA signature revealed a panel of 14 lncRNAs, i.e., APCDD1L-AS1, H19, LINC00205, LINC00346, LINC00475, LINC00484, LINC00601, LINC00664, LINC00886, LUCAT1, MIR155HG, NEAT1, PVT1, and SNHG18. These lncRNA expressions were validated in clinical specimens using qRT-PCR. Robust predictive accuracies of the signature were present across different datasets at multiple timepoints. With univariate and multivariate regressions, we demonstrated that the risk score based on the lncRNA signature is an independent prognostic indicator after clinical factors were adjusted. A nomogram was constructed with these prognostic factors, and it has demonstrated decent classification and accuracy. Additionally, the signature-based classification was observed to be correlated with multiple clinical characteristics and molecular subtypes. Further, extensive immune cells were upregulated in the high-risk group, such as CD8+ T cell, neutrophil, macrophage, and myeloid dendritic cell, indicating increased immune infiltrations.Conclusion: We established a novel ferroptosis-related lncRNA signature that could effectively stratify the prognosis of glioma patients with adequate predictive performance.

show abstract

Long noncoding RNA LINC00346 promotes glioma cell migration, invasion and proliferation by up‐regulating ROCK1

Cited by 9 publications

References 48 publications

Identification of Prognostic Signature of Necroptosis-Related lncRNAs and Molecular Subtypes in Glioma

Identification of Prognostic Signature of Necroptosis-Related lncRNAs and Molecular Subtypes in Glioma

Analysis of multi‐omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances

A Novel lncRNA Panel Related to Ferroptosis, Tumor Progression, and Microenvironment is a Robust Prognostic Indicator for Glioma Patients

Contact Info

Product

Resources

About