2016
DOI: 10.1126/scitranslmed.aaf1475
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Long noncoding RNA Chast promotes cardiac remodeling

Abstract: Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in cardiac development. However, understanding of lncRNAs in cardiac diseases is still limited. Global lncRNA expression profiling indicated that several lncRNA transcripts are deregulated during pressure overload-induced cardiac hypertrophy in mice. Using stringent selection criteria, we identified Chast (cardiac hypertrophy-associated transcript) as a potential lncRNA candidate that influences cardiomyocyte hypertrophy. Cell f… Show more

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Cited by 333 publications
(229 citation statements)
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References 44 publications
(34 reference statements)
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“…GapmeR-mediated Chast-silencing both prevented and attenuated experimentally induced hypertrophic cardiac remodeling [123].…”
Section: Therapeutic Potential Of Autophagic Modulation In Chronic Hementioning
confidence: 97%
“…GapmeR-mediated Chast-silencing both prevented and attenuated experimentally induced hypertrophic cardiac remodeling [123].…”
Section: Therapeutic Potential Of Autophagic Modulation In Chronic Hementioning
confidence: 97%
“…For example, lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) has been shown to regulate endothelial cell function, 9 whereas lncRNA SENCR (smooth muscle and endothelial cell-enriched migration/ differentiation-associated long noncoding RNA) has been demonstrated to stabilize the smooth muscle cell contractile phenotype. 10 Recent experimental studies have outlined the importance of lncRNAs in modulating clinically relevant processes such as cholesterol synthesis 11 and cardiac hypertrophy, 12 making them promising molecular targets in cardiovascular disease. However, the contribution of lncRNAs to hPC function is yet unclear.…”
Section: Editorial See P 320 Meet the First Author See P 312mentioning
confidence: 99%
“…In a whole-genome lncRNA profiling study of TAC-operated mice, Viereck et al [3] identified a RNA transcript named cardiac hypertrophy-associated ( Chast ) being highly expressed in cardiomyocytes from hypertrophic hearts. Similarly, human Chast homolog expression was induced in hypertrophic heart tissue from aortic stenosis patients.…”
Section: Lncrnas In Cariomyocytesmentioning
confidence: 99%
“…Mechanistically, Chast overlaps with Plekhml , which is a regulatory factor for autophagy [4]. Plekhml expression inversely correlated with Chast and silencing of Plekhml mimicked the Chast overexpression phenotype, thereby blocking autophagy of cardiomyocytes and promoting cardiac hypertrophy [3]. …”
Section: Lncrnas In Cariomyocytesmentioning
confidence: 99%