Long noncoding RNA HOTAIR polymorphisms and susceptibility to bipolar disorder: a preliminary case–control study

Sargazi, Saman; Abghari, Armin Zahedi; Mirinejad, Shekoufeh; Nia, Milad Heidari; Majidpour, Mahdi; Danesh, Hiva; Sheervalilou, Roghayeh; Shakiba, Mansoor; Abghari, Fateme Zahedi

doi:10.1080/15257770.2022.2065017

Cited by 11 publications

(9 citation statements)

References 60 publications

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“…The expression of HOTAIR (HOX transcript antisense RNA) [40], CCL11 [41], OLIG2 [42] and CRH (corticotropin releasing hormone) [43] might be associated with schizophrenia progression. The abnormal expression of HOTAIR (HOX transcript antisense RNA) [44] might be related to the progression of bipolar disorder. The abnormal expression of HOTAIR (HOX transcript antisense RNA) [45] contributes to the progression of Parkinson’s disease.…”

Section: Discussionmentioning

confidence: 99%

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

Vastrad,

Vastrad

2023

Preprint

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Schizophrenia is thought to be the most prevalent chronic psychiatric disorder. Numerous proteins have been identified that are associated with the occurrence and development of schizophrenia. This study aimed to identify potential core genes and pathways involved in schizophrenia, through exhaustive bioinformatic and next generation sequencing (NGS) data analyses using GSE20966 NGS data of neural progenitor cells and neurons obtained from healthy controls and patients with schizophrenia. The NGS data were downloaded from the Gene Expression Omnibus database. NGS data was processed by the DESeq2 package in R software and the differentially expressed genes (DEGs) were identified. Gene Ontology (GO) enrichment analysis and REACTOME pathway enrichment analysis were carried out to identify potential biological functions and pathways of the DEGs. Protein-protein interaction (PPI) network, module, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis were performed to identify the hub genes, miRNA and TFs. Potential hub genes were analyzed using receiver operating characteristic (ROC) curves in the R package (pROC). In this investigation, an overall 955 DEGs were identified: 478 genes were remarkably up regulated and 477 genes were distinctly down regulated. These genes were enriched for GO terms and pathways mainly involved in the multicellular organismal process, GPCR ligand binding, regulation of cellular process and amine ligand-binding receptors. MYC, FN1, CDKN2A, EEF1G, CAV1, ONECUT1, SYK, MAPK13, TFAP2A and BTK were considered the potential hub genes. miRNA-hub gene regulatory network and TF-hub gene regulatory network were constructed successfully. On the whole, the findings of this investigation enhance our understanding of the potential molecular mechanisms of schizophrenia and provide potential targets for further investigation.

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Section: Discussionmentioning

confidence: 99%

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

Vastrad,

Vastrad

2023

Preprint

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“…However, no links between rs1899663 SNP and the development of methamphetamine addiction or schizophrenia were observed in any of the inheritance models assessed (Sayad et al 2020 ). Another clinical study in subjects diagnosed with bipolar disorder (and controls) implicated HOTAIR SNPs rs1899663 G/T, rs12826786 C/T, rs4759314 A/G, and rs920778 C/T as risk factors for the development of bipolar disorder under allelic, recessive, dominant, and co-dominant contrasted genetic models (Sargazi et al 2022 ). Interestingly, while CT genotype of rs920778 C/T, GT genotype of rs1899663 G/T, and CT genotype of rs12826786 C/T SNPs were proposed to increase the chances of bipolar disorder development, GG genotype of rs4759314 A/G SNP was proposed to attenuate the risk (Sargazi et al 2022 ).…”

Section: Hotair In Non-oncological Brain Pathophysiological ...mentioning

confidence: 99%

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

Ahmad,

Sudesh,

Ahmed

et al. 2024

Cell Mol Neurobiol

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HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA (lncRNA) which is increasingly being perceived as a tremendous molecular mediator of brain pathophysiology at multiple levels. Epigenetic regulation of target gene expression carried out by HOTAIR is thorough modulation of chromatin modifiers; histone methyltransferase polycomb repressive complex 2 (PRC2) and histone demethylase lysine-specific demethylase 1 (LSD1). Incidentally, HOTAIR was the first lncRNA shown to elicit sponging of specific microRNA (miRNA or miR) species in a trans-acting manner. It has been extensively studied in various cancers, including gliomas and is regarded as a prominent pro-tumorigenic and pro-oncogenic lncRNA. Indeed, the expression of HOTAIR may serve as glioma grade predictor and prognostic biomarker. The objective of this timely review is not only to outline the multifaceted pathogenic roles of HOTAIR in the development and pathophysiology of gliomas and brain cancers, but also to delineate the research findings implicating it as a critical regulator of overall brain pathophysiology. While the major focus is on neuro-oncology, wherein HOTAIR represents a particularly potent underlying pathogenic player and a suitable therapeutic target, mechanisms underlying the regulatory actions of HOTAIR in neurodegeneration, traumatic, hypoxic and ischemic brain injuries, and neuropsychiatric disorders are also presented. Graphical Abstract HOTAIR-mediated epigenetic DNA regulation and molecular sponging of target miRNAs. While the 5′ end of HOTAIR regulates the H3K27 trimethylation activity of the catalytic subunit enhancer of Zeste homolog 2 (EZH2) of the polycomb repressive complex 2 (PRC2), its 3′ end modulates the H3K4 demethylation activity of lysine-specific demethylase 1 (LSD1). HOTAIR also binds to and competitively inhibits the functions of target miRNAs, altering the expression of downstream genes.

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“…10 Saman Sargazi et al showed that HOTAIR polymorphisms of long-stranded non-coding RNA are associated with susceptibility to bipolar disorder. 11 Mohammad Ali Mokhtari et al showed that genetic polymorphisms in miR-137 and its target genes TCF4 and CACNA1C lead to the risk of bipolar disorder. 12 lncRNA expression and function are affected by single nucleotide polymorphism and have a correlation with the pathogenesis of mental diseases.…”

Section: Introductionmentioning

confidence: 99%

Association Between Single Nucleotide Polymorphisms Within lncRNA NONHSAT102891 and Depression Susceptibility in a Chinese Population

Liang

Sun

et al. 2023

NDT

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Background Depression is among the most common psychiatric disorders, and is a leading cause of the global disease burden. Its pathophysiological mechanism is unclear, which limits the development of therapeutic strategies. Long non-coding RNA (lncRNA) single nucleotide polymorphisms (SNPS) may be related. In this study, we aimed to determine the effects of the rs2242385, rs155979, rs3762983, and rs3762984 polymorphisms in the lncRNA NONHSAT102891 on depression susceptibility in a Chinese population. Methods We conducted a case-control study in a cohort of 480 patients with depression and 329 healthy controls, and performed genotyping by gene sequencing ii. Results The rs155979 GC genotype was significantly associated with increased risk of depression compared with healthy controls. Stratified analysis showed a 2.08-fold increased risk of suicide in patients with rs155979 GC or GG genotype. The rs2242385, rs3762983, and rs3762984 polymorphisms were not significantly associated with the risk of depression. Haploid analysis showed linkage disequilibrium between rs155979, rs3762983, and rs3762984, and the CCG haplotype reduced the risk of depression. Limitations The study sample was relatively small, and was restricted to patients from central and southern China. Further, only peripheral blood was used for DNA extraction. Conclusion The rs155979 polymorphism may be associated with the occurrence of depression in the Chinese population. However, further studies are needed to verify the reliability of our results in large populations and different ethnic groups.

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Long noncoding RNA HOTAIR polymorphisms and susceptibility to bipolar disorder: a preliminary case–control study

Cited by 11 publications

References 60 publications

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

Association Between Single Nucleotide Polymorphisms Within lncRNA NONHSAT102891 and Depression Susceptibility in a Chinese Population

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