Long noncoding RNA H19 promotes vascular remodeling by sponging let-7a to upregulate the expression of cyclin D1

Sun, Wei; Lv, Junyuan; Duan, Liren; Lin, Ruoran; Li, Yugang; Li, Shanqiong; Fu, Cuicui; Zhao, Lin; Xin, Shijie

doi:10.1016/j.bbrc.2018.11.185

Cited by 28 publications

(22 citation statements)

References 26 publications

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“…Sun et al found that lncRNA-H19 sponges let-7a, which binds to the 3′ UTR of cyclin D1 mRNA to exert negative regulation; therefore, lncRNA-H19 positively regulates cyclin D1, which is a key factor promoting the proliferation of VSMCs. Hence, lncRNA-H19 promotes the proliferation of VSMCs through the lncRNA-H19/let-7a/cyclin D1 axis (Sun et al 2019c ). Similarly, it was reported that lncRNA-H19 sponges let-7b to stimulate the expression of Ang II type 1 receptor (AT 1 R), which is a critical regulator of vasoconstriction and proliferation of arteries.…”

Section: Lncrna-h19 and The Pathophysiology Of Atherosclerosismentioning

confidence: 99%

Long non-coding RNA H19 in atherosclerosis: what role?

Shi

Wei

et al. 2020

Mol Med

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Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss the roles of lncRNA-H19 in atherosclerosis-related pathophysiological processes and the potential mechanisms by which lncRNA-H19 regulates the development of atherosclerosis, to help provide a better understanding of the biological functions of lncRNA-H19 in atherosclerosis.

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Section: Lncrna-h19 and The Pathophysiology Of Atherosclerosismentioning

confidence: 99%

Long non-coding RNA H19 in atherosclerosis: what role?

Shi

Wei

et al. 2020

Mol Med

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“…lncRNA H19 is one of the long non-coding RNAs, which was one of the first discovered lncRNAs. Experiments have been carried out to show the new role of lncRNA H19 in ceRNA regulatory networks (24), further confirming the complexity and diversity of ceRNA regulatory networks. Therefore, in PCOS, further exploration of lncRNA H19 and biological phenotypes will help us to understand the pathogenesis of PCOS from a macro perspective.…”

Section: Discussionmentioning

confidence: 74%

lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome

Sun

Yan

Liu

et al. 2020

Braz J Med Biol Res

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The etiology of polycystic ovary syndrome (PCOS) is complex and the pathogenesis is not fully understood. Some studies have shown that dysregulation of ovarian granulosa cells may be related to abnormal follicles and excessive androgen in women with PCOS. Our team has also confirmed the high expression status of H19 in PCOS patients in the early stage. However, the relationship between H19 and miR-19b in the development of PCOS is still unknown. Therefore, we used bioinformatics to predict the binding sites of human H19 and miR-19b, and of miR-19b and CTGF genes. After the silencing and overexpression of H19, real-time polymerase chain reaction (PCR) was used to detect the expressions of H19, miR-19b, and CTGF. Western blotting was used to detect CTGF protein. Proliferation of KGN cells after H19 silencing was detected by CCK8. Flow cytometry was used to detect the apoptosis of KGN cells after H19 silencing. After the overexpression of H19, it was found that the expression of miR-19b gene decreased and the expression of CTGF increased, whereas silencing of H19 did the opposite. In addition, H19 could promote cell proliferation and decrease cell apoptosis. Finally, luciferase reporter assays showed that the 3 0-end sequences of lncRNA H19 and CTGF contained the binding site of miR-19b. In conclusion, our study indicated that lncRNA H19 acted as a ceRNA to bind to miR-19b via a ''sponge'' to regulate the effect of CTGF on KGN cells, which may play a vital role in PCOS.

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“…H19 (H19 imprinted maternally expressed transcript), one of the very first identified eukaryote lncRNAs, is highly expressed and wellconserved across mammals in embryonic and prenatal stages [25]. H19 seems to play diverse roles in vascular diseases [49][50][51][52][53]. It was discovered to stimulate VSMC proliferation in vitro, and H19-derived miR-675 was noted to directly target PTEN (Phosphatase and tensin homolog), a key regulator in the phenotypic transition of VSMCs [21,50].…”

Section: H19mentioning

confidence: 99%

Long noncoding RNAs in key cellular processes involved in aortic aneurysms

Trenner

Boon

et al. 2020

Atherosclerosis

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This current review covers studies that have identified long non-coding RNAs in aortic aneurysm development and progression. • We separately discuss transcripts and mechanisms of importance to thoracic as well as abdominal aortic aneurysms. • Functional data on lncRNAs being identified are highlighted. • Some have been studied in human as well as experimental models of the disease pathology.

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Long noncoding RNA H19 promotes vascular remodeling by sponging let-7a to upregulate the expression of cyclin D1

Cited by 28 publications

References 26 publications

Long non-coding RNA H19 in atherosclerosis: what role?

Long non-coding RNA H19 in atherosclerosis: what role?

lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome

Long noncoding RNAs in key cellular processes involved in aortic aneurysms

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