Long Noncoding RNA Functions as a Regulator for Steroid Hormone Receptor-Related Breast and Prostate Cancers

Jin, Chunyu; Rosenfeld, Michael G.

doi:10.1007/978-4-431-55576-6_13

Cited by 1 publication

(2 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical and experimental studies have shown that dysregulation of ER expression and/or its associated signalling pathway is strongly associated with breast cancer development, progression, transition, and endocrine resistance 29 30 . However, few studies have examined ER-targeted lncRNA genes and their functions 10 . We used an array-based method to identify ERAR lncRNA genes and employed an array-based gene co-expression method to explore the potential functions of these lncRNA genes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

Zhang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding–non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan–Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Therefore, lncRNAs associated with ER signalling may serve important regulatory roles in most types of breast cancer. However, few lncRNAs associated with ER signalling have been well-characterized 10 11 .…”

mentioning

confidence: 99%

A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

Zhang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

Long Noncoding RNA Functions as a Regulator for Steroid Hormone Receptor-Related Breast and Prostate Cancers

Cited by 1 publication

References 114 publications

A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

Contact Info

Product

Resources

About