Long noncoding RNA FGD5-AS1 alleviates childhood IgA nephropathy by targeting PTEN-mediated JNK/c-Jun signaling pathway via miR-196b-5p

Sun, Qiang; Li, Xue; Wang, Mingxu; Fan, Jianfeng; Zeng, Haisheng

doi:10.1016/j.yexcr.2023.113481

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…Recently, studies have revealed that lncRNAs take part AGING in IgAN development. For instance, Sun et al found that lncRNA FGD5-AS1 targeted PTEN-involved JNK/c-Jun pathway via sponging miR-196b-5p, contributing to alleviation of childhood IgAN [80]. Shen et al reported that lncRNA CRNDE enhanced activation of NLRP3 inflammasome in macrophages, including Il-1β, TNF-α and IL-12, and exacerbated the malignant progression of IgAN [81].…”

Section: Lncrnas Regulate Iga1 Glycosylationmentioning

confidence: 99%

Deciphering roles of protein post-translational modifications in IgA nephropathy progression and potential therapy

Sun,

Shi,

Zhang

et al. 2024

Aging

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Immunoglobulin A nephropathy (IgAN), one type of glomerulonephritis, displays the accumulation of glycosylated IgA in the mesangium. Studies have demonstrated that both genetics and epigenetics play a pivotal role in the occurrence and progression of IgAN. Post-translational modification (PTM) has been revealed to critically participate in IgAN development and progression because PTM dysregulation results in impaired degradation of proteins that regulate IgAN pathogenesis. A growing number of studies identify that PTMs, including sialylation, o-glycosylation, galactosylation, phosphorylation, ubiquitination and deubiquitination, modulate the initiation and progression of IgAN. Hence, in this review, we discuss the functions and mechanisms of PTMs in regulation of IgAN. Moreover, we outline numerous compounds that govern PTMs and attenuate IgAN progression. Targeting PTMs might be a useful strategy to ameliorate IgAN.

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Section: Lncrnas Regulate Iga1 Glycosylationmentioning

confidence: 99%

Deciphering roles of protein post-translational modifications in IgA nephropathy progression and potential therapy

Sun,

Shi,

Zhang

et al. 2024

Aging

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Comprehensive Analysis of ceRNA Network and Immune Cell Infiltration Pattern of Autophagy-Related Genes in IgA Nephropathy

Zhang,

Lu,

Zhan

et al. 2024

Kidney Blood Press Res

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Introduction: IgA nephropathy (IgAN) is a prevalent worldwide glomerular disease with a complex pathophysiology that has significant economic implications. Despite the lack of successful research, this study aims to discover the potential competing endogenous RNA (ceRNA) network of autophagy-associated genes in IgAN and examine their correlation with immune cell infiltration. Methods: Autophagy-related hub genes were discovered by assessing the GSE116626 dataset and constructing a protein-protein interaction network. Nephroseq v5 analysis engine was used to analyze correlations between hub genes and proteinuria, glomerular filtration rate (GFR) and serum creatinine levels. Then, a ceRNA network construction and the CIBERSORT tool for immune cell infiltration analysis were also performed. Additionally, the differentially expressed autophagy-related genes (DEARGs) were used to predict potential targeted medications for IgAN. Results: 1396 differentially expressed genes (DEGs) were identified in IgAN along with 25 autophagy-related differentially expressed messenger RNAs (DEmRNAs). Enrichment analysis revealed significant involvement of autophagy and apoptosis in biological processes. Next, we evaluated the top hub nodes based on their highest degrees. The ability of IgAN discrimination was confirmed in the GSE35487 and GSE37460 datasets by validating the five hub genes: SIRT1, FOS, CCL2, CDKN1A and MYC. In the Nephroseq v5 analysis engine, the clinical correlation of the five hub genes was confirmed. Furthermore, the ceRNA network identified 18 circular RNAs and 2 microRNAs associated with hub autophagy-related genes in IgAN. Our investigation identified hsa-miR-32-3p and hsa-let-7i-5p as having elevated expression levels and substantial diagnostic value. Finally, four distinctively infiltrated immune cells were found to be associated with the hub autophagy-related genes, and 67 drugs were identified as potential therapeutic options for IgAN. Conclusion: This study sheds light on a novel ceRNA regulatory network mechanism associated with autophagy in IgAN development. Keywords: ImmunoglobulinA nephropathy, Autophagy, ceRNA, Immune cell.

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Long noncoding RNA FGD5-AS1 alleviates childhood IgA nephropathy by targeting PTEN-mediated JNK/c-Jun signaling pathway via miR-196b-5p

Cited by 2 publications

References 46 publications

Deciphering roles of protein post-translational modifications in IgA nephropathy progression and potential therapy

Deciphering roles of protein post-translational modifications in IgA nephropathy progression and potential therapy

Comprehensive Analysis of ceRNA Network and Immune Cell Infiltration Pattern of Autophagy-Related Genes in IgA Nephropathy

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