Long noncoding RNA FAM83H‐AS1 exerts an oncogenic role in glioma through epigenetically silencing CDKN1A (p21)

Bi, Yongyan; Shen, Gang; Quan, Yong; Jiang, Wei; Xu, Fulin

doi:10.1002/jcp.26813

Cited by 28 publications

(37 citation statements)

References 43 publications

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“…Afterward, Lu et al confirmed that levels of FAM83H‐AS1 expression were increased in colorectal cancer tissues and cell lines compared with the corresponding normal tissues and human colonic epithelial cell through qRT‐PCR. Moreover, the overexpression of FAM83H‐AS1 was gradually found in breast cancer, lung cancer, pancreatic ductal adenocarcinoma, glioma, and gastric cancer . However, the expression status of FAM83H‐AS1 is still unknown in bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

FAM83H‐AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer

Shan

Yang

Zhu

et al. 2018

J of Cellular Biochemistry

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FAM83H-AS1, also known as oncogenic long noncoding RNA (lncRNA)-3, is a novel lncRNA that has been suggested to be dysregulated in a variety of human cancers. However, the expression status and function of FAM83H-AS1 in bladder cancer are still unknown. The object of our study is to explore the clinical value of FAM83H-AS1 in patients with bladder cancer and the biological function of FAM83H-AS1 in bladder cancer cells. In our results, the expression of FAM83H-AS1 was obviously elevated in bladder cancer tissue samples and bladder cancer cell lines compared with adjacent normal tissue samples and normal bladder epithelial cell lines, respectively. In addition, high expression of FAM83H-AS1 was associated with advanced clinical stage and the presence of muscularis invasion and served as an independent poor prognostic factor for overall survival in patients with bladder cancer. The loss-of-function study showed that silencing FAM83H-AS1 expression suppressed cell proliferation, migration, and invasion and induced cycle arrest at G0/G1 phase. In conclusion, FAM83H-AS1 is involved in the progression of bladder cancer and serves as a prognostic biomarker and potential therapeutic target for patients with bladder cancer. K E Y W O R D S biomarker, bladder cancer, FAM83H-AS1, long noncoding RNA (lncRNA) J Cell Biochem. 2019;120:4687-4693.wileyonlinelibrary.com/journal/jcb X. FAM83H-AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer.

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Section: Discussionmentioning

confidence: 99%

FAM83H‐AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer

Shan

Yang

Zhu

et al. 2018

J of Cellular Biochemistry

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“…The 14 studies contained 2818 patients from three countries including China, United States and Iran. We mainly analyzed nine different types of tumors, including pancreatic ductal adenocarcinoma [13], gastric cancer [7,14,15], ovarian cancer [8,16], glioma [9], colorectal carcinoma [17,18], bladder cancer [10], hepatocellular carcinoma [6], breast cancer [19], and lung cancer [20]. The expression of FAM83H-AS1 was detected by quantitative real-time fluorescent PCR in all studies.…”

Section: Characteristics and Basic Information In Eligible Literaturementioning

confidence: 99%

“…Another study showed that patients with ovarian cancer were more easily accompanied by high expression of FAM83H-AS1, which was correlated with tumor pathological grade, tumor lymph node metastasis (TNM) stage and distant metastasis [8]. Overexpressed FAM83H-AS1 exhibited oncogenic functions in glioma by suppressing expression of CDKN1A, which encoded a key factor that regulated the G1 phase of the cell cycle, leading to increased cell proliferation [9]. Furthermore, high expression of FAM83H-AS1 was related to advanced clinical stage in bladder cancer and FAM83H-AS1 was more likely to lead to invasion of muscle layer, suggesting FAM83H-AS1 could be an independent poor prognostic factor for OS in bladder cancer patients [10].…”

Section: Introductionmentioning

confidence: 99%

The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis

Yang¹,

Wang²,

Zhong³

et al. 2020

Cancer Cell Int

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Background: Family with sequence similarity 83 member H antisense RNA 1 (FAM83H-AS1) is a novel long noncoding RNA. Increasing studies have reported that FAM83H-AS1 is abnormally expressed in a variety of tumors and is associated with poor outcome. However, the clinical prognostic significance of lncRNA FAM83H-AS1 in tumors is not completely known. Methods:In this meta-analysis, literature was collected up until February 5, 2020 through multifarious retrieval strategies by searching through electronic databases of PubMed, Cochrane Library, EMBASE, Medline, Web of Science, CNKI, Weipu, and Wanfang. A total of 14 studies that met the inclusion criteria with relevant clinical data and prognostic information were included in the meta-analysis. Results:The combined results revealed that high expression of FAM83H-AS1 was associated with poor overall survival (OS) (HR = 1.63, 95% CI 1.24-2.14, P = 0.0004) in a variety of cancers. Additionally, upregulated FAM83H-AS1 expression was significantly correlated with tumor TNM stage (III/IV vs. I/II, OR = 2.40, 95% CI 1.36-4.23, P = 0.003) and lymph node metastasis (positive vs. negative, OR = 1.70, 95% CI 1.14-2.52, P = 0.008) in patients with cancer. Conclusions:Our results of this meta-analysis indicated that elevated FAM83H-AS1 expression could predict poor prognosis in patients with cancer and suggested that FAM83H-AS1 might serve as a novel biomarker for cancer.

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“…FAM83H-AS1 expression is upregulated in certain gastric cancer(272) and HNSCC(272) studies, while others show variable alterations in gastric(273) and HNSCC(133) tissues.Thus, FAM83H-AS1 could potentially be a diagnostic marker in those cancers. High expression of FAM83H-AS1 correlates with worse overall survival in breast(270), colorectal(271,276), lung(272), pancreatic(274), glioma brain(275), and cervical cancers (Chapter 2); therefore, FAM83H-AS1 could potentially be a prognostic marker in those cancer types. FAM83H-AS1 is mainly localized in the epithelium in pancreatic cancer cells(274) and specifically in the nucleus in lung cancer(272), cervical cancer (Chapter 2), and glioma brain cancer(275) cells.…”

mentioning

confidence: 99%

“…FAM83H-AS1 expression is up-regulated at least in part by HPV-16 E6 and p300 in cervical cancer cells (Chapter 2). Downstream, FAM83H-AS1 regulates Notch signaling in colorectal cancer(276), MET/EGFR signaling in lung cancer(272), and p21 expression in glioma(275). Further studies need to be conducted to determine if these upstream and downstream targets involved with FAM83H-AS1 expression are consistent between cancer types, and novel upstream and downstream regulators of FAM83H-AS1 expression need to be elucidated to increase therapeutic potential of targeting FAM83H-AS1.…”

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confidence: 99%

Regulation of the long non-coding RNA FAM83H-AS1 by human papillomavirus in cervical cancer

Barr.¹,

Ann²

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Regulation of the long non-coding RNA FAM83H-AS1 by human papillomavirus in cervical cancer Jamie A. Barr Non-coding RNAs (NcRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been found to be involved in a variety of critical biological processes, and dysregulation of ncRNAs have been involved with several human diseases including cancer. High-risk human papillomavirus (HPV) infection is one of the first events in the process of carcinogenesis in cervical and a subset of head and neck cancers. The expression of the viral oncoproteins E6 and E7 is essential in this process by inactivating the tumor suppressor proteins p53 and Rb, respectively, in addition to their interactions with other host proteins and regulation of ncRNAs. Our group identified novel regulation of host lncRNAs by HPV oncoprotein E6. More specifically, we discovered that a lncRNA known as FAM83H-AS1 is involved with proliferation, migration, and apoptosis in cervical cells, and high expression of this lncRNA correlates with poor overall cervical cancer patient survival. FAM83H-AS1 is a nuclear RNA, and mechanistically it is regulated through the E6-p300 pathway in a p53-independent manner. These findings provide knowledge of a specific lncRNA that could be studied further as a biomarker and/or therapeutic target not only in HPV-related cancers but also in other types of cancers where FAM83H-AS1 expression is dysregulated. In parallel with these studies, our group identified a specific subgroup of miRNAs that are induced during quiescence and processed by a non-canonical biogenesis pathway by using primary human cells. miRNA expression is dysregulated when cells undergo a reversible state of growth arrest known as quiescence. These primary (pri-)miRNAs are modified with a 2,2,7-trimethylguanosine (TMG)cap such that they are processed downstream in an Exportin-1 (XPO1)-dependent manner, independent of the canonical Exportin-5 (XPO5) protein used for exportation to the cytoplasm. The discovery of a new alternative miRNA pathway in quiescent primary human cells opens the door to future studies in other types of cells, such as stem cells and cancer stem cells, where the state of quiescence is important in their biological functions. iii Dedication This dissertation is dedicated to my parents, Ron and Regina Barr, who raised me to be hardworking and taught me persistence to strive to accomplish my goals while still enjoying the journey along the way. I am truly blessed to have such loving parents who have supported me through every aspect of my life. This dissertation work would not have been possible without them. I also want to thank my loving fiancé, Chris Juric, who provided constant optimism, laughter, and happiness when life was challenging, and motivation to continue working hard to complete this work. This dissertation is also dedicated to my Godparents, Larry Barr and Carol Pacofsky, who provided multiple care packages to brighten my day and reassurance that everything would work out. I would also like to dedicate thi...

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Long noncoding RNA FAM83H‐AS1 exerts an oncogenic role in glioma through epigenetically silencing CDKN1A (p21)

Cited by 28 publications

References 43 publications

FAM83H‐AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer

FAM83H‐AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer

The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis

Regulation of the long non-coding RNA FAM83H-AS1 by human papillomavirus in cervical cancer

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