Long Noncoding RNA EGFR-AS1 Promotes Cell Proliferation by Increasing EGFR mRNA Stability in Gastric Cancer

Hu, Jiaojiao; Qian, Yingying; Peng, Lifang; Ma, Ling; Qiu, Tianzhu; Xiao, Li; Chen, Xiaofeng

doi:10.1159/000492883

Cited by 36 publications

(34 citation statements)

References 35 publications

(41 reference statements)

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“…Previous studies revealed that lncRNAs participate in many cancers, such as gastric cancer, bladder cancer, and lung cancer [20–22]. It has been reported that long non-coding RNA FBXL19-AS1 plays oncogenic role in colorectal cancer [13].…”

Section: Discussionmentioning

confidence: 99%

FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer

Qian

Cheng

et al. 2019

Bioscience Reports

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Lung cancer is the leading cause of cancer-related mortality worldwide, characterized by uncontrolled proliferation and metastasis of lung cancer cells. Tumor angiogenesis plays a key role in proliferation and metastasis in cancers, and is an essential component in microenvironment. It has been reported that long non-coding RNA FBXL19-AS1 plays an oncogenic role in colorectal cancer. However, the molecular mechanism of FBXL19-AS1 in lung cancer has not been fully elucidated. In the present study, we found that FBXL19-AS1 expression was up-regulated in lung cancer tissues and cell lines. FBXL19-AS1 knockdown inhibited cell proliferation, migration, invasion, and angiogenesis in lung cancer cells. Molecular mechanism exploration uncovered that FBXL19-AS1 acted as a molecular sponge of miR-431-5p and that RAF1 was a downstream target of miR-431-5p in lung cancer. Moreover, there was a negative association between miR-431-5p expression and FBXL19-AS1 or RAF1 expression in tumor tissues. Through rescue experiments, we discovered that overexpression of RAF1 partially rescued FBXL19-AS1 knockdown-mediated inhibition of angiogenesis and progression in lung cancer. Together, these results indicated that FBXL19-AS1 was involved in progression and angiogenesis in lung cancer by targeting miR-431-5p/RAF1 axis, which provided a new insight into the therapeutic strategies of lung cancer.

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Section: Discussionmentioning

confidence: 99%

FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer

Qian

Cheng

et al. 2019

Bioscience Reports

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“…Recently, numerous studies have discovered that lncRNAs participate in the regulation of cellular processes of cancers including cell proliferation, metastasis, apoptosis, autophagy and epithelial‐mesenchymal transition, thus functioning as oncogenes or tumor suppressors . LncRNAs can exert their biological functions to regulate gene expression through various molecular mechanisms including epigenetic modification, RNA alternative splicing and interaction with target miRNA, mRNA or protein .…”

Section: Introductionmentioning

confidence: 99%

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

et al. 2019

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The aberrant expression of long non‐coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction‐associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up‐regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. In addition, knockdown of MIAT inhibited proliferation, migration, invasion and promoted apoptosis of OS cells in vitro. Moreover, the expression of MIAT was negatively associated with miR‐128‐3p but positively correlated with vascular endothelial growth factor C (VEGFC) in OS. Further mechanistic study revealed that lncRNA MIAT promoted OS progression by up‐regulating VEGFC via sponging miR‐128‐3p in vitro. Taken together, our results suggest that MIAT/miR‐128‐3p/VEGFC axis contributes to OS progression and may be used as a novel therapeutic target for OS. © 2019 IUBMB Life, 9999(9999):1–9, 2019

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“…Noncoding RNAs link their associated genes with complex regulatory networks . Previous studies have implicated lncRNAs in diverse cellular processes that range from chromatin remodeling, histone modification and epigenetic silencing, to RNA stabilization and transcription . The highly complex nature of lncRNAs indicates that these are key regulators in cellular process and tumor progression.…”

Section: Introductionmentioning

confidence: 99%

HNRNPAB‐regulated lncRNA‐ELF209 inhibits the malignancy of hepatocellular carcinoma

Yang

Chen

Piao

et al. 2019

Intl Journal of Cancer

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Our previous study demonstrated that heterogeneous nuclear ribonucleoprotein AB (HNRNPAB) is a key gene that facilitates metastasis of hepatocellular carcinoma (HCC). However, the molecular mechanisms behind this relationship are not fully understood. In our study, we utilized long‐noncoding RNA (lncRNA) microarrays to identify a HNRNPAB‐regulated lncRNA named lnc‐ELF209. Our findings from chromatin immunoprecipitation assays indicate that HNRNPAB represses lnc‐ELF209 transcription by directly binding to its promoter region. We also analyzed clinical samples from HCC patients and cell lines with quantitative real‐time polymerase chain reactions, RNA in situ hybridization and immunohistochemistry, and found that there is a negative relationship between HNRNPAB and lnc‐ELF209 expression. Up/downregulation assays and rescue assays indicate that lnc‐ELF209 inhibits cell migration, invasion and epithelial–mesenchymal transition regulated by HNRNPAB. This suggests a new regulatory mechanism for HNRNPAB‐promoted HCC progression. RNA pull‐down and LC–MS/MS were used to determine triosephosphate isomerase, heat shock protein 90‐beta and vimentin may be involved in the tumor‐suppressed function of lnc‐ELF209. Furthermore, we found lnc‐ELF209 could stabilize TPI protein expression. We also found that lnc‐ELF209 overexpression in HCCLM3 cell resulted in a lower rate of lung metastatic, which suggested a less aggressive HCC phenotype. Collectively, these findings offer new insights into the regulatory mechanisms that underlie HNRNPAB cancer‐promoting activities and demonstrate that lnc‐ELF209 is a HNRNPAB‐regulated lncRNA that may play an important role in the inhibition of HCC progression.

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Long Noncoding RNA EGFR-AS1 Promotes Cell Proliferation by Increasing EGFR mRNA Stability in Gastric Cancer

Cited by 36 publications

References 35 publications

FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer

FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

HNRNPAB‐regulated lncRNA‐ELF209 inhibits the malignancy of hepatocellular carcinoma

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