Long noncoding RNA activated by TGF-β in human cancers: A meta-analysis

Fan, Yanghua; Ji, Chenxing; Xu, Bing; Fan, Hengyi; Cheng, Zujue; Zhu, Xingen

doi:10.1016/j.cca.2017.02.001

Cited by 28 publications

(22 citation statements)

References 31 publications

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“…As a kind of noncoding RNA with more than 200 nucleotides in length, lncRNAs lack the capacity of protein-coding. Recently, numerous studies have proposed its promising value as biomarkers for early tumor screening and prognosis, as well as clinical therapy for various types of carcinomas [ 31 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Miao

Zhao

Zhu

et al. 2017

BioMed Research International

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Recent researches have demonstrated that long noncoding RNA linc00152 was aberrantly upregulated in multiple tumor types. High expression of linc00152 was associated with poor outcomes in cancer patients. Therefore, we conducted this meta-analysis to evaluate its potential value as a prognostic predictor in various human neoplasms. Eligible studies were searched through several electronic databases including PubMed, Embase, Web of Science, and the Cochrane Library. Eight original studies including 752 cancer patients were ultimately enrolled. Statistical analysis suggested that overexpression of linc00152 was significantly correlated with unfavorable overall survival (OS) (HR = 2.05, 95% CI: 1.59–2.64) and disease-free/progression-free survival (DFS/PFS) (HR = 3.52, 95% CI: 1.82–6.79) in cancer patients. In addition, a significant correlation was observed between aberrant linc000152 expression and lymph node metastasis (LNM) (OR = 2.49, 95% CI: 1.57–3.94) but not in vessel invasion (VI) (OR = 1.02, 95% CI: 0.54–1.93) and distant metastasis (DM) (OR = 0.600, 95% CI: 0.213–1.689). Our meta-analysis demonstrated that high linc00152 expression significantly predicted inferior OS and DFS/PFS in multiple neoplasms, as well as advanced LNM and VI. Linc00152 may serve as a potential indicator in predicting poor outcomes and metastases of diverse cancers.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Miao

Zhao

Zhu

et al. 2017

BioMed Research International

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“…According to the standard guidelines of meta-analyses [ 37 , 38 ], a systematic search was performed by two authors independently in the electronic databases of Medline, Pubmed, OVID, and Web of Science for relevant articles that concerned TUG1 as a prognostic biomarker for the survival of cancer patients. The latest search was updated on Jan 11, 2017.…”

Section: Methodsmentioning

confidence: 99%

Long non-coding RNA TUG1 as a potential prognostic biomarker in human cancers: a meta-analysis

Guan

et al. 2017

Oncotarget

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LncRNA taurine upregulated gene 1 (TUG1) is reportedly dysregulated in various cancers. We performed this meta-analysis to clarify the usefulness of TUG1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Jan 11, 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to explore the relationship between TUG1 expression and overall survival (OS). Odds ratios (ORs) were calculated to assess the association between TUG1 expression and pathological parameters. Thirteen original studies covering 1,274 cancer patients were included in this meta-analysis. The pooled HR suggested that high TUG1 expression correlated with poor OS (pooled HR=1.41, 95% CI: 1.01-1.98) in cancer types other than non-small cell lung cancer. TUG1 expression was also related to distant metastasis (OR=3.24, 95% CI: 1.18-8.93), large tumor size (OR=4.07, 95% CI: 1.08-15.28) and advanced tumor stage (OR=3.45, 95% CI: 2.19-5.44). Begg’s funnel plot and Egger’s test showed no evidence of obvious asymmetry for overall survival or tumor stage. Thus high TUG1 expression appears predictive of poor OS, distant metastasis, advanced tumor stage and large tumor size. This suggests TUG1 expression could serve as a biomarker for poor prognosis in cancers.

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“…LncRNA-ATB (activated by TGF-β), located on chromosome 14, was first reported as highly expressed in hepatocellular carcinoma (HCC) and showed extensive regulatory functions [ 86 ]. The lncRNA-ATB expressed in 57 pairs of PC and adjacent non-cancerous prostate tissues.…”

Section: Introductionmentioning

confidence: 99%

Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star

Lin

Cheng

et al. 2018

Mol Cancer

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Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Recent advances in the non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack coding protein function, termed non-coding RNA (ncRNA). It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in diverse diseases are not yet fully understood. Thus, it is anticipated that more efforts should be made to clarify the lncRNA world. Moreover, accumulating evidence has demonstrated that many lncRNAs are dysregulated in prostate cancer (PC) and closely related to tumorigenesis, metastasis, and prognosis or diagnosis. In this review, we will briefly outline the regulation and functional role of lncRNAs in PC. Finally, we discussed the potential of lncRNAs as prospective novel targets in PC treatment and biomarkers for PC diagnosis.

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Long noncoding RNA activated by TGF-β in human cancers: A meta-analysis

Cited by 28 publications

References 31 publications

Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Long non-coding RNA TUG1 as a potential prognostic biomarker in human cancers: a meta-analysis

Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star

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