Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression

Nishitsuji, Hironori; Ujino, Saneyuki; Yoshio, Sachiyo; Sugiyama, Masaya; Mizokami, Masashi; Kanto, Tatsuya; Shimotohno, Kunitada

doi:10.1073/pnas.1525022113

Cited by 78 publications

(80 citation statements)

References 39 publications

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“…Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNAs emerge to play essential roles in gene-specific transcriptional regulation of innate immunity via controlling chromatin status and gene expression. [45][46][47] These chromatin modifiers perform coordinated actions to convert the extracellular stimuli into the complex gene expression patterns during innate inflammatory responses. At the steady state, the poised/inactive enhancers are occupied by lineage-determining transcription factors known as pioneers, such as PU.1 and marked with a combination of H3K4me1 and repressive H3K27me3.…”

Section: Molecular Regulation Of Innate Immunity and Inflammationmentioning

confidence: 99%

Cellular and molecular regulation of innate inflammatory responses

2016

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Section: Molecular Regulation Of Innate Immunity and Inflammationmentioning

confidence: 99%

Cellular and molecular regulation of innate inflammatory responses

2016

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“…Similar results have been obtained with BISPR (BST2 IFN-stimulated positive regulator). BISPR is a lncRNA induced by IFN [79][80][81] expressed from a bidirectional promoter that also drives BST2/tetherin. After IFN signaling, BISPR is expressed first, accumulates in the nucleus, and can act in trans to activate transcription of BST2, probably, by counteracting the suppressive role of PRC2 [80].…”

Section: Lncrnas Affecting the Expression Of Specific Isgs Located Nementioning

confidence: 99%

LncRNAs in HCV Infection and HCV-Related Liver Disease

Unfried¹,

Fortes²

2020

IJMS

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Long non-coding RNAs (lncRNAs) are transcripts with poor coding capacity that may interact with proteins, DNA, or other RNAs to perform structural and regulatory functions. The lncRNA transcriptome changes significantly in most diseases, including cancer and viral infections. In this review, we summarize the functional implications of lncRNA-deregulation after infection with hepatitis C virus (HCV). HCV leads to chronic infection in many patients that may progress to liver cirrhosis and hepatocellular carcinoma (HCC). Most lncRNAs deregulated in infected cells that have been described function to potentiate or block the antiviral response and, therefore, they have a great impact on HCV viral replication. In addition, several lncRNAs upregulated by the infection contribute to viral release. Finally, many lncRNAs have been described as deregulated in HCV-related HCC that function to enhance cell survival, proliferation, and tumor progression by different mechanisms. Interestingly, some HCV-related HCC lncRNAs can be detected in bodily fluids, and there is great hope that they could be used as biomarkers to predict cancer initiation, progression, tumor burden, response to treatment, resistance to therapy, or tumor recurrence. Finally, there is high confidence that lncRNAs could also be used to improve the suboptimal long-term outcomes of current HCC treatment options.

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“…Likewise, Nishitsuji et al indicated that hnRNPU binds and stabilizes lncRNA#32. This lncRNA further binds to activating transcription factor to induce ISGs transcription, and, thus, repressing viral replication (Nishitsuji et al, 2016).…”

Section: Immune Response Employs Long Noncoding Rnas Against Virusesmentioning

confidence: 99%