Long Noncoding Ribonucleic Acid SNHG18 Promotes Glioma Cell Motility via Disruption of α-Enolase Nucleocytoplasmic Transport

Zheng, Rong; Yao, Qingzhou; Li, Xiaobo; Xu, Benhua

doi:10.3389/fgene.2019.01140

Cited by 30 publications

(31 citation statements)

References 35 publications

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“…In contrast, OTX2-AS1 was significantly enriched in the floor-plate cluster together with TP53TG1 , implicated in carcinoma but not as yet associated with a neuronal phenotype [ 33 ] ( Figure 6 D–F and Supplementary Figure S3E ). This cluster of immature cells was also characterized by SNHG18 [ 34 ], known to play an oncogenic role in glioma, LINC0052 [ 35 ], which acts as a sponge for miR-608, and the annotated transcripts AC026124.1 , AL132780.2 , and AC026401.3 ( Figure 6 D–F and Supplementary Figure S3E ).…”

Section: Resultsmentioning

confidence: 99%

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation

Nilsson

Storm

Sozzi

et al. 2021

Cells

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Dopaminergic (DA) neurons derived from human pluripotent stem cells (hPSCs) represent a renewable and available source of cells useful for understanding development, developing disease models, and stem-cell therapies for Parkinson’s disease (PD). To assess the utility of stem cell cultures as an in vitro model system of human DA neurogenesis, we performed high-throughput transcriptional profiling of ~20,000 ventral midbrain (VM)-patterned stem cells at different stages of maturation using droplet-based single-cell RNA sequencing (scRNAseq). Using this dataset, we defined the cellular composition of human VM cultures at different timepoints and found high purity DA progenitor formation at an early stage of differentiation. DA neurons sharing similar molecular identities to those found in authentic DA neurons derived from human fetal VM were the major cell type after two months in culture. We also developed a bioinformatic pipeline that provided a comprehensive long noncoding RNA landscape based on temporal and cell-type specificity, which may contribute to unraveling the intricate regulatory network of coding and noncoding genes in DA neuron differentiation. Our findings serve as a valuable resource to elucidate the molecular steps of development, maturation, and function of human DA neurons, and to identify novel candidate coding and noncoding genes driving specification of progenitors into functionally mature DA neurons.

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Section: Resultsmentioning

confidence: 99%

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation

Nilsson

Storm

Sozzi

et al. 2021

Cells

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“…Overexpressing CRNDE promotes EMT in oral epithelial cell carcinoma and osteosarcoma [39,40]. In glioma, high SNHG18 expression enhances radiation resistance, and triggers EMT by increasing ENO1 expression [41]. To the best of our knowledge, no studies have investigated the effects of these lncRNAs on PMT in glioma.…”

Section: Discussionmentioning

confidence: 99%

Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma

Liang

Guan

et al. 2020

J Transl Med

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Background Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes, unfavorable prognosis, and treatment resistance. Recent studies have highlighted that long non-coding RNAs (lncRNAs) are key mediators in cancer mesenchymal transition. However, the relationship between lncRNAs and PMT in glioma has not been systematically investigated. Methods Gene expression profiles from The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), GSE16011, and Rembrandt with available clinical and genomic information were used for analyses. Bioinformatics methods such as weighted gene co-expression network analysis (WGCNA), gene set enrichment analysis (GSEA), Cox analysis, and least absolute shrinkage and selection operator (LASSO) analysis were performed. Results According to PMT scores, we confirmed that PMT status was positively associated with risky behaviors and poor prognosis in glioma. The 149 PMT-related lncRNAs were identified by WGCNA analysis, among which 10 (LINC01057, TP73-AS1, AP000695.4, LINC01503, CRNDE, OSMR-AS1, SNHG18, AC145343.2, RP11-25K21.6, RP11-38L15.2) with significant prognostic value were further screened to construct a PMT-related lncRNA risk signature, which could divide cases into two groups with distinct prognoses. Multivariate Cox regression analyses indicated that the signature was an independent prognostic factor for high-grade glioma. High-risk cases were more likely to be classified as the mesenchymal subtype, which confers enhanced immunosuppressive status by recruiting macrophages, neutrophils, and regulatory T cells. Moreover, six lncRNAs of the signature could act as competing endogenous RNAs to promote PMT in glioblastoma. Conclusions We profiled PMT status in glioma and established a PMT-related 10-lncRNA signature for glioma that could independently predict glioma survival and trigger PMT, which enhanced immunosuppression.

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“…A previous study showed that decreased expression of lncRNA-H19 inhibited HSC activation and alleviated liver fibrosis in vivo and in vitro 18 . lncRNA SNHG18 acts as a tumour suppressor in hepatocellular carcinoma(HCC)and an independent diagnostic marker for liver cancer 19 ; it promots cell motility by regulating EMT progression and remodelling the cytoskeleton 20 . The clinical and diagnostic value of SNHG18 in patients with HCC was investigated for the first time, and it was found that SNHG18 was significantly down-regulated in HCC tissues compared to the corresponding noncancerous tissues 21 .…”

Section: Discussionmentioning

confidence: 99%

Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration

Zhang

Xie

et al. 2021

Sci Rep

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Wilson's Disease (WD), an ATP7B-mutated inherited disease that affects copper transport, is characterised by liver and nervous system manifestations. Long non-coding (ln-c) RNAs are widely involved in almost all physiological and pathological processes in the body, and are associated with numerous diseases. The present study aimed to elucidate the lncRNA-mRNA regulation network in a TX WD mouse model using RNA sequencing (RNA-seq). lncRNA expression profiles were screened using RNA-seq and real-time polymerase chain reaction, and differentially expressed lncRNAs and mRNAs were identified. To analyse the biological functions and pathways for the differentially expressed mRNAs, gene ontology and pathway enrichment analyses were performed. A significantly correlated lncRNA-mRNA relationship pair was calculated by CNC analysis to construct differential lncRNA and mRNA co-expression networks. A total of 2564 significantly up-regulated and 1052 down-regulated lncRNAs, and 1576 up-regulated and 297 down-regulated mRNAs, were identified. These genes were found to be associated with key processes such as apoptosis, and KEGG analysis revealed enrichment in the drug metabolism-cytochrome P450 pathway, PPAR signalling pathway, Notch signalling pathway, and MAPK signalling pathway. The identified differential lncRNAs may be involved in the pathogenesis and development of WD liver injury.

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Long Noncoding Ribonucleic Acid SNHG18 Promotes Glioma Cell Motility via Disruption of α-Enolase Nucleocytoplasmic Transport

Cited by 30 publications

References 35 publications

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation

Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma

Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration

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