Long non‐coding <scp>RNA RP</scp>11‐552M11.4 promotes cells proliferation, migration and invasion by targeting <scp>BRCA</scp>2 in ovarian cancer

Huang, Kejin; Geng, Jiashi; Wang, Jing

doi:10.1111/cas.13552

Cited by 25 publications

(20 citation statements)

References 42 publications

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“…Emerging studies have validated that numerous lncRNA are aberrantly expressed in EOC and play crucial roles in tumorigenesis and progression . For instance, the expression of the lncRNA human ovarian cancer‐specific transcript 2 (HOST2) was found to be upregulated in EOC tissue, promoting cell proliferation and metastasis by sponging miRNA let‐7b .…”

Section: Discussionmentioning

confidence: 99%

“…Emerging studies have validated that numerous lncRNA are aberrantly expressed in EOC and play crucial roles in tumorigenesis and progression. 15,16 For instance, the expression of the lncRNA human ovarian cancer-specific transcript 2 (HOST2) was found to be upregulated in EOC tissue, promoting cell proliferation and metastasis by sponging miRNA let-7b. 17 In addition, highly expressed homeobox (HOX) transcript antisense intergenic RNA (HOTAIR) was found to be closely related to poor EOC prognosis and the promotion of EOC migration and invasion through matrix metalloproteinases (MMP) and epithelial-mesenchymal transition (EMT) in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

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LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

Wei

Gao

et al. 2019

Cancer Science

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Increasing numbers of studies have confirmed that long noncoding RNA (lnc RNA ) play a critical role in epithelial ovarian cancer ( EOC ) progression. However, the potential function of the lnc RNA tumor protein translationally controlled 1 ( TPT 1) antisense RNA 1 ( TPT 1‐ AS 1) in EOC is unclear. In this study, we aimed to uncover the biological roles and regulatory mechanisms of TPT 1‐ AS 1 in EOC progression and metastasis. First, TPT 1‐ AS 1 expression was significantly higher in EOC metastatic tissue and cell lines than in their respective control counterparts. In addition, ectopic TPT 1‐ AS 1 expression was strongly associated with unfavorable EOC clinicopathological features, including FIGO stage, tumor size and tumor differentiation. TPT 1‐ AS 1 overexpression remarkably induced cell proliferation, migration and invasion, and significantly attenuated cell adhesion ability in vitro and facilitated nude mouse subcutaneous xenograft growth and intraperitoneal metastasis in vivo, while the downregulation of TPT 1‐ AS 1 expression produced the opposite effect in vitro. Mechanistically, TPT 1‐ AS 1 was proven to be primarily distributed in EOC cell nuclei and positively modulated TPT 1 promoter activity and transcription. Moreover, the oncogenic effects of TPT 1‐ AS 1 could be reversed by TPT 1 depletion, and the PI 3K/ AKT signaling pathway downstream of TPT 1 was also altered. These results suggested that TPT 1‐ AS 1 induced EOC tumor growth and metastasis through TPT 1 and downstream PI 3K/ AKT signaling and that TPT 1‐ AS 1 may be a promising therapeutic target for EOC .

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

Wei

Gao

et al. 2019

Cancer Science

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“…Although only a small portion of lncRNAs have been characterized in detail, many lncRNAs have emerged as regulators of various biological processes, such as epigenetic regulation, alternative splicing, RNA decay, cell cycle control, and cell fate determination . Furthermore, multiple lines of evidence suggest that the abnormal expression of lncRNAs is associated with the development of diverse human diseases, and specific lncRNAs have also been shown to play a critical role in tumor initiation and progression, including PDAC . For example, LINC00673 is able to promote protein tyrosine phosphatase PTPN11 degradation through ubiquitination, resulting in decreased proliferation of pancreatic cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

Zhang

Yang

et al. 2019

Cancer Science

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Long noncoding RNAs (lncRNAs) are emerging as key regulators in cancer initiation and progression. TP53TG1 is a recently identified lncRNA and several studies have shown that TP53TG1 may play the role of tumor suppressor gene or oncogene in different tumors. Nevertheless, the involvement of TP53TG1 in carcinogenesis of pancreatic ductal adenocarcinoma (PDAC) has not been characterized. In our studies, we identified that TP53TG1 was highly expressed in PDAC and was a novel regulator of PDAC development. Knockdown of TP53TG1 inhibited proliferation, induced apoptosis, and decreased migration and invasion in PDAC cells, whereas enhanced expression of TP53TG1 had the opposite effects. Mechanistically, TP53TG1 could directly bind to microRNA (miR)‐96 and effectively function as a sponge for miR‐96, thus antagonizing the functions of miR‐96 and leading to derepression of its endogenous target KRAS, which is a core oncogene in the initiation and maintenance of PDAC. Taken together, these observations imply that TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR‐96 and regulate KRAS expression, which highlights the importance of the complicated miRNA‐lncRNA network in modulating the progression of PDAC.

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“…Cell apoptosis rate was detected at 24 hours post‐transfection using FITC Annexin V Apoptosis Detection Kit II (Catalog number: 556547; BD) according to the instructions of manufacturer. Besides, cell invasive ability was detected by Matrigel invasion assay using Matrigel basement membrane matrix (Catalog number: 356234; BD), Transwell filter chamber (Catalog number: 3422; Coring), formaldehyde solution (Catalog number: 818708; Sigma), and crystal violet (Catalog number: 46364; Sigma) according to the method described previously …”

Section: Methodsmentioning

confidence: 99%

Integrin α7 high expression correlates with deteriorative tumor features and worse overall survival, and its knockdown inhibits cell proliferation and invasion but increases apoptosis in breast cancer

Bai

Gao

Zhang

et al. 2019

Clinical Laboratory Analysis

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Background This study aimed to investigate the correlation of integrin α7 (ITGA7) expression with clinical/pathological characteristics and overall survival (OS), and its knockdown on inhibiting cell activities in breast cancer. Methods A total of 191 breast cancer patients underwent surgery were retrospectively reviewed, and ITGA7 expression in tumor tissues was determined by immunofluorescence and real‐time quantitative polymerase chain reaction. Patients’ clinical/pathological data were recorded, and OS was calculated. In vitro, control shRNA and ITGA7 shRNA plasmids were transfected into MCF7 cells to evaluate the influence of ITGA7 knockdown on cell proliferation, apoptosis, and invasion. Results Ninety‐two (48.2%) patients presented with ITGA7 high expression, and 99 patients (51.8%) presented with ITGA7 low expression. ITGA7 expression was positively correlated with T stage, tumor‐node metastasis (TNM) stage, and pathological grade. Kaplan‐Meier curves showed that ITGA7 high expression was associated with shorter OS, and multivariate Cox's proportional hazards regression displayed that ITGA7 high expression was an independent predictive factor for poor OS. Moreover, in vitro experiments disclosed that cell proliferation (by Cell Counting Kit‐8 assay) and cell invasion (by Matrigel invasion assay) were reduced, while cell apoptosis rate (by Annexin V/propidium iodide assay) was enhanced by ITGA7 knockdown in MCF‐7 cells. Conclusion Integrin α7 high expression correlates with increased T stage, TNM stage, and pathological grade as well as worse OS, and its knockdown enhances cell apoptosis but inhibits cell proliferation and invasion in breast cancer.

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Long non‐coding RNA RP11‐552M11.4 promotes cells proliferation, migration and invasion by targeting BRCA2 in ovarian cancer

Cited by 25 publications

References 42 publications

LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

Integrin α7 high expression correlates with deteriorative tumor features and worse overall survival, and its knockdown inhibits cell proliferation and invasion but increases apoptosis in breast cancer

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