Long non‐coding <scp>RNA DUXAP9</scp> promotes hepatocellular carcinoma cell stemness via directly interacting with sox9

Zeng, Ru; Wang, Chunyue; Wang, Wenyi; Wang, Shuangjia

doi:10.1002/tox.23300

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…LncRNAs have been revealed to function through different ways, such as acting as miRNA sponges, RNA, or protein partners, 16 such as, our previous study indicates that lncRNA MALAT1 acts as a partner for YAP protein and enhances YAP protein stability and thus increases YAP expression 17 ; LncRNA DUXAP9 can facilitate the stemness of hepatocellular carcinoma cells via directly interacting with Sox9 mRNA 18 ; LncRNA THOR increases the stemness of osteosarcoma cells by interacting and enhancing Sox9 mRNA stability 19 . Notably, a recent study indicates that lncRNA can encode a small peptide, through which lncRNA suppresses colon cancer progression 20 .…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability

Mao

2022

Environmental Toxicology

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Long noncoding RNA (lncRNA) OIP5-AS1 was shown to facilitate drug resistance and metastasis in several tumors. As cancer stem cells (CSCs) have been elucidated as the origin of drug resistance and tumor progression, we speculate that lncRNA OIP5-AS1 holds critical roles in the CSC-like traits of lung cancer. Here, lncRNA OIP5-AS1 was found to be highly expressed in lung cancer cell spheres. Following experiments showed that OIP-AS1 knockdown reduced the CSC-like traits of lung cancer spheres, while overexpression of OIP-AS1 conferred the CSC-like traits in lung cancer cells by performing sphere-formation analysis, detecting stemness marker expression, and ALDH activity. Mechanistic studies revealed that lncRNA OIP5-AS1 could increase Oct4 expression by directly interacting with Oct4 mRNA and enhancing Oct4 mRNA stability. Finally, we found that the knockdown of Oct4 could rescue the promoting effects of OIP5-AS1 overexpression on the CSC-like traits of lung cancer. These results demonstrate that lncRNA OIP5-AS1 can confer lung cancer CSC-like traits by directly interacting with Oct4 mRNA and thus increasing Oct4 mRNA stability and expression.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability

Mao

2022

Environmental Toxicology

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“…CD73, as a novel marker for liver CSCs, in addition to activating the AKT signaling pathway to promote the SOX9 transcription by c-MYC activation, also protects SOX9 from proteasome-mediated degradation by GSK3β inhibition, therefore maintaining the liver CSCs properties [ 118 ]. Similarly, lncDUXAP9 improves the mRNA stability of SOX9 and up-regulates its expression by binding to the 3’UTR of SOX9, thereby sustaining the stemness of HCC [ 119 ].…”

Section: Sox Transcription Factors In Hepatocellular Carcinomamentioning

confidence: 99%

Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy

Luo

Xie

et al. 2022

Cancers

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Sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) factors belong to an evolutionarily conserved family of transcription factors that play essential roles in cell fate decisions involving numerous developmental processes. In recent years, the significance of SOX factors in the initiation and progression of cancers has been gradually revealed, and they act as potential therapeutic targets for cancer. However, the research involving SOX factors is still preliminary, given that their effects in some leading-edge fields such as tumor immune microenvironment (TIME) remain obscure. More importantly, as a class of ‘undruggable’ molecules, targeting SOX factors still face considerable challenges in achieving clinical translation. Here, we mainly focus on the roles and regulatory mechanisms of SOX family members in hepatocellular carcinoma (HCC), one of the fatal human health burdens worldwide. We then detail the role of SOX members in remodeling TIME and analyze the association between SOX members and immune components in HCC for the first time. In addition, we emphasize several alternative strategies involved in the translational advances of SOX members in cancer. Finally, we discuss the alternative strategies of targeting SOX family for cancer and propose the opportunities and challenges they face based on the current accumulated studies and our understanding.

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“…For instance, SOX9 drives endocrine resistance in breast carcinoma, 11 determines lung carcinoma cell plasticity or metastatic progression 12 and induces invasion and metastasis in basal cell carcinoma 13 and melanoma 14 . SOX9 also regulates tumorigenicity and cancer progression in hepatocellular cancer, 15 prostate carcinoma, 16 colorectal carcinoma, 17 pancreatic ductal adenocarcinoma, 18,19 medulloblastoma 20 and gastric cancer 21 . Recent studies show that tissues from different sources continue to express SOX9 in the stem cell pools, 22 and there are evidences that it may regulate CSCs 23,24 .…”

Section: Introductionmentioning

confidence: 99%

Upregulation of SOX9 promotes the self‐renewal and tumorigenicity of cervical cancer through activating the Wnt/β‐catenin signaling pathway

Feng,

Cui,

et al. 2023

The FASEB Journal

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Sry‐box9 (SOX9) maintains stem cell properties and plays crucial roles in many cancers. However, whether SOX9 is correlated with cervical cancer cell stemness and its detailed mechanism remains obscure. We studied the relationship between SOX9 and prognosis of cervical cancer through public database, and SOX9 was related to poor prognosis of cervical cancer. Elevated SOX9 expression enhanced the self‐renewal properties and promotes tumorigenicity in cervical cancer. Overexpression of SOX9 could promote the expression of stem cell‐related factors in cervical cancer cells and xenografts. Meanwhile, overexpression of SOX9 could also enhance the expressions of FZD10, β‐catenin, and c‐Myc in cervical cancer cells and xenografts, while inhibiting the expression of DDK1. The activation of Wnt pathway by chir‐99 021 raised the tumor spheroid ability of SOX9 knockdown HeLa cells. In addition, SOX9 could transcriptional inhibit DKK1 and activate FZD10 and MYC by binding to their promoters to affect the Wnt/β‐catenin pathway. These results demonstrated SOX9 regulated the self‐renewal and tumorigenicity of cervical cancer through Wnt/β‐catenin pathway by directly transcriptional activation of FZD10, MYC and transcriptional inhibition of DKK1.

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Long non‐coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9

Cited by 12 publications

References 25 publications

Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability

Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability

Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy

Upregulation of SOX9 promotes the self‐renewal and tumorigenicity of cervical cancer through activating the Wnt/β‐catenin signaling pathway

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