Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

Kiang, Karrie Mei-Yee; Zhang, Xiaoqin; Leung, Gilberto Ka Kit

doi:10.3390/cancers7030843

Cited by 79 publications

(92 citation statements)

References 129 publications

(165 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brain glioma is the most common primary tumor of the central nervous system, and one of the main causes of death in patients with intracranial tumors . The poor prognosis and high recurrence rate of glioma is largely due to the abundant blood flow, rapid growth, susceptibility of invasion to surrounding normal brain tissues and resistance to radiotherapy and chemotherapy . The tumorigenesis of glioma is biologically complex, involving a series of pathophysiological changes, and expression changes of many genes and signaling pathways .…”

Section: Introductionmentioning

confidence: 99%

“…With the development of microarray and high‐throughput sequencing technologies in recent years, accumulating studies have shown that a large number of differentially expressed lncRNAs between normal brain tissues and different grades of gliomas were verified, and many lncRNAs extensively participate in the tumorigenesis of glioma by modulating the proliferation, apoptosis, invasion and metastasis of glioma cells. lncRNAs can not only be important markers for the diagnosis of glioma, but used as important prognostic indicators in patients with glioma . However, despite the efforts made on the study of the tumorigenesis and progression of glioma, the clinical outcome remains unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel lncRNA‐LINC01116 regulates tumorigenesis of glioma by targeting VEGFA

Zhu

Chen

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

Brain glioma is the most common malignant tumor of the central nervous system, and one of the leading causes of death in patients with intracranial tumors. The clinical outcome of glioma is usually poor due to abundant vascularity, fast growth and susceptibility of invasion to normal brain tissues. Our microarray study showed that lncRNA‐LINC01116 was significantly upregulated in glioma tissues and played an important role in cell proliferation, cycle, migration, invasion and angiogenesis. In addition, vascular endothelial growth factor (VEGFA) may be the major target genes in the downstream of lncRNA‐LINC01116. Dual luciferase assay showed that LINC01116 and VEGFA both contained a miR‐31‐5p binding site, and LINC01116 could regulate the expression of VEGFA through competitive absorption of miR‐31‐5p. RNA immunoprecipitation indicated that LINC01116 and VEGFA were present in the miR‐31‐5p‐RISC complex, and biotinylated miR‐31‐5p pull‐down assay suggested that there was a competitive relationship between LINC01116 and VEGFA to bind with miR‐31‐5p. Collectively, our study has identified a novel lncRNA‐LINC01116 and clarified the role and mechanism of LINC01116 in the tumorigenesis of glioma. LINC01116 may prove to be a potential target for the clinical diagnosis and treatment of glioma.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel lncRNA‐LINC01116 regulates tumorigenesis of glioma by targeting VEGFA

Zhu

Chen

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Increasing evidence has shown that lncRNAs are responsible for essential gene regulatory functions in various tissues (Guttman et al, ; Liu et al, ; Zhu et al, ). As in brain, research has shown that many lncRNAs are highly expressed in the brain (Kiang, Zhang, & Leung, ), and taken specific expression means specific function into consideration, high expression means important functions in normal brain development and brain‐related diseases, such as glioma (Y. Wang & Lan, ; O. Wang et al, ; Yu et al, ). Actually, several lncRNAs have been proven to haa ve function in brain development (Sauvageau et al, ; Trojan et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA gastric cancer‐associated transcript 3 plays oncogenic roles in glioma through sponging miR‐3127‐5p

Pan

Zhao

2018

Journal Cellular Physiology

View full text Add to dashboard Cite

Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer‐associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma has not been elucidated. Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. Next, we determined that GACAT3 contributes to glioma progression through inhibiting microRNA (miR)‐3127‐5p. Subsequently, ELAVL1 was identified as a direct target of miR‐3127‐5p by bioinformatics analysis and luciferase reporter assay. Moreover, we confirmed that GACAT3 promoted ELAVL1 expression through sponging miR‐3127‐5p, leading to glioma progression. Taken together, our study elucidated that GACAT3/miR‐3127‐5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target.

show abstract

“…Table 2 shows functionally validated lncRNAs involved in embryogenesis that have also been identified as oncogenic or tumour suppressors in glioma cancer biology 31, 46, 47, 48, 49…”

Section: Functions Of Lncrnas In Glioma Biologymentioning

confidence: 99%

Long non‐coding RNAs in brain tumours: Focus on recent epigenetic findings in glioma

Pop

Enciu

Necula

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Glioma biology is a major focus in tumour research, primarily due to the aggressiveness and high mortality rate of its most aggressive form, glioblastoma. Progress in understanding the molecular mechanisms behind poor prognosis of glioblastoma, regardless of treatment approaches, has changed the classification of brain tumours after nearly 100 years of relying on anatomopathological criteria. Expanding knowledge in genetic, epigenetic and translational medicine is also beginning to contribute to further elucidating molecular dysregulation in glioma. Long non‐coding RNAs (lncRNAs) and their main representatives, large intergenic non‐coding RNAs (lincRNAs), have recently been under scrutiny in glioma research, revealing novel mechanisms of pathogenesis and reinforcing others. Among those confirmed was the reactivation of events significant for foetal brain development and neuronal commitment. Novel mechanisms of tumour suppression and activation of stem‐like behaviour in tumour cells have also been examined. Interestingly, these processes involve lncRNAs that are present both during normal brain development and in brain malignancies and their reactivation might be explained by epigenetic mechanisms, which we discuss in detail in the present review. In addition, the review discusses the lncRNAs‐induced changes, as well as epigenetic changes that are consequential for tumour formation, affecting, in turn, the expression of various types of lncRNAs.

show abstract

Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

Cited by 79 publications

References 129 publications

A novel lncRNA‐LINC01116 regulates tumorigenesis of glioma by targeting VEGFA

A novel lncRNA‐LINC01116 regulates tumorigenesis of glioma by targeting VEGFA

Long noncoding RNA gastric cancer‐associated transcript 3 plays oncogenic roles in glioma through sponging miR‐3127‐5p

Long non‐coding RNAs in brain tumours: Focus on recent epigenetic findings in glioma

Contact Info

Product

Resources

About