Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets

Ray, Roslyn M.; Morris, Kevin V.

doi:10.3390/ncrna6010012

Cited by 20 publications

(22 citation statements)

References 115 publications

(195 reference statements)

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“…Expression of lncRNA EGOT, NEAT1, BISPR/LncBST2, LINC01191/VIN/lnc-ACTR3, ISR (IFN-stimulated lncRNA) 2 and ISR8, LOC100506319/LINC01988/LncRNA-PAAN, LOC102637961/lncRNA-ACOD1, MIR155HG, TSPOAP1-AS1, PSMB8-AS1, PSORS1C3, IVRPIE was increased and expression of NRAV/DYNLL1AS1 was decreased in IAV infected cells 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 . In HIV infected cells expression of ISR2, NEAT1, GOMAFU/MIAT, LUST/RBM5-AS1, BIC/MIR155HG, MALAT1, NRIR/lncCMPK2, MIR3945HG, FIRRE, LINC02574, LINC01426 is increased while expression of NRON, PANDAR/PANDA, CDKN2B-AS1/ANRIL DD3/PCA, DANCR, CMPD/LINC01152, NCRMS/RMST, GAS5, LINC00173, lincRNA-p21/TP53COR1 and SAF/FAS-AS1 is decreased 29 , 30 , 31 . Increased expression of NEAT1, MAMDC2-AS1, PRINS, ISR2 and LOC102637961/lncRNA-ACOD1 is observed in HSV infected cells 24 , 27 , 32 , 33 , 34 .…”

Section: Introductionmentioning

confidence: 99%

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

Laha

Saha

Dutta

et al. 2021

Heliyon

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Altered expression of long noncoding RNA (lncRNA), longer than 200 nucleotides without potential for coding protein, has been observed in diverse human diseases including viral diseases. It is largely unknown whether lncRNA would deregulate in SARS-CoV-2 infection, causing ongoing pandemic COVID-19. To identify, if lncRNA was deregulated in SARS-CoV-2 infected cells, we analyzed in silico the data in GSE147507. It was revealed that expression of 20 lncRNA like MALAT1, NEAT1 was increased and 4 lncRNA like PART1, TP53TG1 was decreased in at least two independent cell lines infected with SARS-CoV-2. Expression of NEAT1 was also increased in lungs tissue of COVID-19 patients. The deregulated lncRNA could interact with more than 2800 genes/proteins and 422 microRNAs as revealed from the database that catalogs experimentally determined interactions. Analysis with the interacting gene/protein partners of deregulated lncRNAs revealed that these genes/proteins were associated with many pathways related to viral infection, inflammation and immune functions. To find out whether these lncRNAs could be regulated by STATs and interferon regulatory factors (IRFs), we used ChIPBase v2.0 that catalogs experimentally determined binding from ChIP-seq data. It was revealed that any one of the transcription factors IRF1, IRF4, STAT1, STAT3 and STAT5A had experimentally determined binding at regions within -5kb to +1kb of the deregulated lncRNAs in at least 2 independent cell lines/conditions. Our analysis revealed that several lncRNAs could be regulated by IRF1, IRF4 STAT1 and STAT3 in response to SARS-CoV-2 infection and lncRNAs might be involved in antiviral response. However, these in silico observations are necessary to be validated experimentally.

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Section: Introductionmentioning

confidence: 99%

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

Laha

Saha

Dutta

et al. 2021

Heliyon

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“…uc002yug.2, by activating latent HIV and HIV replication, can be a potential therapeutic target ( 56 , 63 ). HEAL may be an attractive therapeutic target to inhibit HIV-1 latency, particularly considering that it is only upregulated in infected CD4+ and macrophages ( 53 , 55 , 63 ). SAF, involved in the resistance of HIV-1–infected macrophages to activation of apoptotic caspases, is a potential therapeutic target specifically intended for HIV cellular reservoirs ( 63 , 66 ).…”

Section: Hiv/aidsmentioning

confidence: 99%

Non-Coding RNAs in the Etiology and Control of Major and Neglected Human Tropical Diseases

et al. 2021

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Non-coding RNAs (ncRNAs) including microRNAs (miRs) and long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in immune cells development and function. Their expression is altered in different physiological and disease conditions, hence making them attractive targets for the understanding of disease etiology and the development of adjunctive control strategies, especially within the current context of mitigated success of control measures deployed to eradicate these diseases. In this review, we summarize our current understanding of the role of ncRNAs in the etiology and control of major human tropical diseases including tuberculosis, HIV/AIDS and malaria, as well as neglected tropical diseases including leishmaniasis, African trypanosomiasis and leprosy. We highlight that several ncRNAs are involved at different stages of development of these diseases, for example miR-26-5p, miR-132-3p, miR-155-5p, miR-29-3p, miR-21-5p, miR-27b-3p, miR-99b-5p, miR-125-5p, miR-146a-5p, miR-223-3p, miR-20b-5p, miR-142-3p, miR-27a-5p, miR-144-5p, miR-889-5p and miR-582-5p in tuberculosis; miR-873, MALAT1, HEAL, LINC01426, LINC00173, NEAT1, NRON, GAS5 and lincRNA-p21 in HIV/AIDS; miR-451a, miR-let-7b and miR-106b in malaria; miR-210, miR-30A-5P, miR-294, miR-721 and lncRNA 7SL RNA in leishmaniasis; and miR-21, miR-181a, miR-146a in leprosy. We further report that several ncRNAs were investigated as diseases biomarkers and a number of them showed good potential for disease diagnosis, including miR-769-5p, miR-320a, miR-22-3p, miR-423-5p, miR-17-5p, miR-20b-5p and lncRNA LOC152742 in tuberculosis; miR-146b-5p, miR-223, miR-150, miR-16, miR-191 and lncRNA NEAT1 in HIV/AIDS; miR-451 and miR-16 in malaria; miR-361-3p, miR-193b, miR-671, lncRNA 7SL in leishmaniasis; miR-101, miR-196b, miR-27b and miR-29c in leprosy. Furthermore, some ncRNAs have emerged as potential therapeutic targets, some of which include lncRNAs NEAT1, NEAT2 and lnr6RNA, 152742 in tuberculosis; MALAT1, HEAL, SAF, lincRNA-p21, NEAT1, GAS5, NRON, LINC00173 in HIV/AIDS; miRNA-146a in malaria. Finally, miR-135 and miR-126 were proposed as potential targets for the development of therapeutic vaccine against leishmaniasis. We also identify and discuss knowledge gaps that warrant for increased research work. These include investigation of the role of ncRNAs in the etiology of African trypanosomiasis and the assessment of the diagnostic potential of ncRNAs for malaria, and African trypanosomiasis. The potential targeting of ncRNAs for adjunctive therapy against tuberculosis, leishmaniasis, African trypanosomiasis and leprosy, as well as their targeting in vaccine development against tuberculosis, HIV/AIDS, malaria, African trypanosomiasis and leprosy are also new avenues to explore.

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“…Once the virus has took over the translational machinery and has assured the life host mainteinance, the following step is to maintain itself in a replicating yet not distruptive infectious status. HIV-1 v-ncRNAs, by repressing the polycomb gene EZH2, the DNA methyltransferase DNMT3a and the histone deacetylase HDAC1, modulate HIV-1 latency through epigenetic modulation [45,92]. The expression of HSV-1 sisRNAs, maintains viral infection by inhibiting apoptosis and silencing viral lytic gene expression through modification of the viral promoters [93,94].…”

Section: Viral Efficient and Persistent Infection Regulationmentioning

confidence: 99%

Non-Coding RNAs: Strategy for Viruses’ Offensive

Gallo

Bulati

Miceli

et al. 2020

ncRNA

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The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.

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Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets

Cited by 20 publications

References 115 publications

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

Non-Coding RNAs in the Etiology and Control of Major and Neglected Human Tropical Diseases

Non-Coding RNAs: Strategy for Viruses’ Offensive

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