Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) β. LncRNA-HIT-MEDIATED TGF-INDUCED EPITHELIAL TO MESENCHYMAL TRANSITION IN MAMMARY EPITHELIA.

Richards, Edward J.; Z, Gu; Li, Zhupeng; Permuth-Wey, Jennifer; Challa, Sridevi; Li, Yajuan; Kong, William; Su, Dan; Coppola, Domenico; Mao, Weimin; Sellers, Thomas A.; Cheng, Jin Q.

doi:10.1074/jbc.a114.610915

Cited by 53 publications

(71 citation statements)

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“…Mathematical predictions and experimental confirmation suggest that feedback loops between transcription factors and miRNAs function as reversible switches to promote TGF-β-induced EMT in a stepwise manner [73][74][75]. lncRNAs also contribute to TGF-β-induced EMT [76][77][78]. TGF-β-induced lncRNA-ATB (activated by TGF-β) enhances ZEB1 and ZEB2 expression by binding to the miR-200 family in hepatocellular carcinoma [76].…”

Section: Tgf-β-induced Emt In Cancer Progressionmentioning

confidence: 99%

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

et al. 2018

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Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-β in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Recent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors may be useful for the treatment of some cancers. TGF-β plays a pivotal role in the differentiation and function of regulatory T cells (Tregs). TGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressed on the surface of Tregs contains glycoprotein A repetitions predominant (GARP, also known as leucine-rich repeat containing 32 or LRRC32). Inhibition of the TGF-β activities through regulation of the latent TGF-β complex activation will be discussed.

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Section: Tgf-β-induced Emt In Cancer Progressionmentioning

confidence: 99%

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

et al. 2018

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“…lncRNA-HIT is an uncharacterized lncRNA located in the HOXA gene cluster, which functions in the nucleus and is significantly induced by TGF-β (138). Richards et al (138) found that lncRNA-HIT performs an important role in TGF-β-induced EMT, migration and invasion. Depletion of lncRNA-HIT significantly increases E-cadherin and reduces vimentin in mouse mammary gland epithelial cells, and inhibits TGF-β induced migration, invasion and EMT.…”

Section: Hoxa Transcript Induced By Tgf-β (Hit)mentioning

confidence: 99%

“…Depletion of lncRNA-HIT significantly increases E-cadherin and reduces vimentin in mouse mammary gland epithelial cells, and inhibits TGF-β induced migration, invasion and EMT. lncRNA-HIT is also significantly elevated in the highly metastatic mouse mammary tumor cell line (4T1) (138). Knockdown of lncRNA-HIT in this cell line results in significant reduction of cell migration, invasion, tumor growth and lung metastasis (138).…”

Section: Hoxa Transcript Induced By Tgf-β (Hit)mentioning

confidence: 99%

“…lncRNA-HIT is also significantly elevated in the highly metastatic mouse mammary tumor cell line (4T1) (138). Knockdown of lncRNA-HIT in this cell line results in significant reduction of cell migration, invasion, tumor growth and lung metastasis (138). Furthermore, lncRNA-HIT is conserved in humans and its expression is associated with more invasive breast cancer progression (138).…”

Section: Hoxa Transcript Induced By Tgf-β (Hit)mentioning

confidence: 99%

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Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis

Zhang¹,

Luo²,

Zhang³

et al. 2017

Oncology Letters

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Abstract. Breast cancer (BC) is now the most common malignancy worldwide, with high prevalence and lethality among women. Invasion and metastasis are the major reasons for breast cancer-associated mortality. However, the underlying mechanism of invasion and metastasis has not been entirely elucidated. Long non-coding RNAs (lncRNAs) are a large class of non-coding transcripts that are >200 bases in length and cannot encode proteins. Evidence has indicated that lncRNAs regulate gene expression at the levels of epigenetic modification, transcription and post-transcription. In addition, they are involved in diverse tumor biological processes, including cell proliferation, apoptosis, invasion, metastasis and angiogenesis. The present review focuses on the recent progress of lncRNAs in breast cancer invasion and metastasis, aiming to provide novel strategies for the clinical prevention, diagnosis and treatment of breast cancer.

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“…En retour, les cellules tumorales ayant subi une TEM vont modifier leur environnement. Elles libèrent en effet des facteurs solubles (facteurs de croissance, cytokines, chimiokines) qui servent de médiateurs de communication de microARN ou de lncARN (ARN longs non codants) [7,8]. Bien que l'implication de la TEM dans la dissémination métastatique reste encore un sujet de controverse [9,10], de nombreuses observations montrent, au moins dans certains types tumoraux, que sa réactiva-tion aberrante peut constituer un événement déterminant des étapes précoces de celle-ci.…”

Section: Rôle Du Microenvironnement Dans La Plasticité Des Cellules Cunclassified

Plasticité des cellules cancéreuses et dissémination métastatique

et al. 2016

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> La dissémination métastatique repose sur une séquence d'événements qui aboutit à la colonisation par les cellules cancéreuses d'un tissu à distance de la tumeur primaire. Il s'agit d'un processus inefficace, chaque étape représentant un obstacle que seul un petit nombre de cellules réussit à franchir. Deux phénomènes intrinsèquement associés au développement tumoral favorisent cependant leur dissémination au sein de l'organisme et la formation de métastases : la diversité génétique des cellules cancéreuses au sein d'une tumeur et la plasticité conférée à ces cellules par des signaux provenant du microenvironnement. La transition épithélio-mésenchymateuse, processus de trans-différenciation cellulaire, joue un rôle important dans ce contexte en accordant aux cellules tumorales une capacité unique de motilité, de survie et d'adaptation aux stress et aux nouveaux environnements rencontrés au cours des différentes phases de la dissémination métastatique. < manière individuelle ou collective, dans le tissu conjonctif intra-et péritumoral, entraînant une invasion locale. Cette étape précoce peut être dissociée des suivantes puisqu'une tumeur invasive localement ne devient pas forcément métastatique à distance. Le processus d'intravasation constitue une étape critique de la dissémination des cellules tumorales au sein de l'organisme puisqu'elle consiste en la traversée de la paroi des vaisseaux sanguins ou lymphatiques par les cellules cancéreuses pour entrer dans la circulation. Ce phénomène est favorisé par l'angiogenèse d'origine tumorale ou « néo-angiogenèse », c'est-à-dire la formation de nouveaux vaisseaux capables d'irriguer la tumeur en développement [39] (➜). Les cellules qui survivent aux pressions physiques et aux contraintes soumises par la circulation pourront procéder par la suite à l'étape d'extravasion, la sortie des vaisseaux leur permettant d'atteindre et de coloniser un organe cible. La sélection de ces organes est dépendante des caractéristiques biologiques de ces derniers, notamment de la microcirculation et du microenvironnement tissulaire, et des caractéristiques des cellules tumorales qui leur confèrent un tropisme tissulaire qui leur est propre. Les dernières étapes de la progression métastatique correspondent à l'implantation des cellules tumorales extravasées dans l'organe cible sous forme de cellules isolées ou d'amas pauci-cellulaires (c'est-à-dire comprenant peu de cellules), puis à la formation de micrométastases et enfin à la formation de métastases cliniquement décelables (Figure 1)

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Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) β. LncRNA-HIT-MEDIATED TGF-INDUCED EPITHELIAL TO MESENCHYMAL TRANSITION IN MAMMARY EPITHELIA.

Abstract: PAGE 6862:Lanes 5 and 6 of the U6 panel of Fig. 4C were missing in the original published figure. The revised figure shows these lanes. This correction does not affect the results or conclusions of this work.

Cited by 53 publications

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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis

Plasticité des cellules cancéreuses et dissémination métastatique

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