Long Non-coding RNAs: key players in brain and central nervous system development

Abstract

CanadaComputational Molecular Biology (Online, ISSN 1927-5587) ), indexed by international database ProQuest, is an open access, peer reviewed journal publishing original research papers of general interest involving in the computational biology at the molecular level.The Journal is publishing all the latest and outstanding research articles, letters, methods, and reviews in all areas of Computational Molecular Biology, covering new discoveries in molecular biology, from genes to genomes, using statistical, mathematical, and computational methods as well as new development of computational methods and databases in molecular and genome biology.The papers published in the journal are expected to be of interests to computational scientists, biologists, and teachers/students/researchers engaged in biology, as well as are appropriate for R & D personnel and general readers interested in computational technology and biology.Computational Molecular Biology is published independently by BioPublisher. It is committed to publishing and disseminating significant original achievements in the related research fields of molecular biology. Vol.4, No.5, 1-13 (doi: 10.5376/cmb.2014.04.0005) Abstract Regulatory long non-coding RNAs have been emerged as a major contribution of cognitive evolution in mammalian central nervous system and brain tissues. Though proteins have relatively conserved during evolution, the lncRNAs have evolved rapidly to cope with essential and widespread cellular regulation, partly by directing generic protein function. Long non-coding RNAs, highly yet specifically expressed in mammalian brain, provide tissue-and neuronal activity-specific epigenetic and transcriptional regulation. lncRNAs have been documented to be essential for brain development and be involved in brain related diseases. We suggest that lncRNAs are important to modulate diverse central nervous system processes and are the major factor that is important to the brain development, which may be employed to develop novel diagnostic and therapeutic strategies to treat brain related diseases. Moreover, animal models with altered lncRNA expressions and high-throughput approaches would help to understand the mechanisms of lncRNAs in brain development and the etiology of lncRNA-driven human neurological diseases.