“…Moreover, our results exhibited the increased levels of COX-2, NO, IL-1β, IL-6, TNF-α, MDA, cleaved caspase-3, NOX4, iNOS and p47phox whereas reduced levels of SOD, collagen I, and collagen III further support our hypothesis. Additionally, LncRNA RP5-833A20.1 has also been reported to elevate the levels of inflammatory factors, such as IL-1β, IL-6, and, TNF-α in THP-1 macrophages in cardiovascular disease [ 23 ]. Besides, inhibition of lncRNA HIF 1 alpha-antisense RNA 1 (HIF1α-AS1) by siRNA can suppress the apoptosis and promote the proliferation of VSMCs by decreasing the caspase-3 expression in thoracic aortic aneurysms [ 24 ].…”