Long Non-Coding RNAs Associated with Heterochromatin Function in Immune Cells in Psychosis

Sudhalkar, Niyati; Rosen, Cherise; Melbourne, Jennifer K.; Park, Mi Rae; Chase, Kayla A.; Sharma, Rajiv P.

doi:10.3390/ncrna4040043

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…these transcripts has been associated with PANSS score (17). Moreover, clinical diagnoses of psychosis and symptom severity have been shown to alter expression of a number of lncRNAs (22) indicating a substantial role for these transcripts in the pathogenesis of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…They reported diagnostic differences with MEG3, PINT, and GAS5, and symptom acuity effect with MEG3 and GAS5. Moreover, there was significant difference in the expression of MEG3 between drug naïve patients and patients received risperidone (22). IFNG-AS1 expression has been shown to be down-regulated in patients with schizophrenia compared with healthy subjects in correlation with IFNG expression indicating a putative role for inflammation in this disorder (23).…”

Section: Lncrna Profile In Peripheral Bloodmentioning

confidence: 98%

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A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis

et al. 2021

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Schizophrenia is a destructive neuropsychiatric disease with a median prevalence of 4.0 per 1,000 during the whole life. Genome-wide association studies have shown the role of copy number variants (generally deletions) and certain alleles of common single nucleotide polymorphisms in the pathogenesis of schizophrenia. This disorder predominantly follows the polygenic inheritance model. Schizophrenia has also been linked with various alterations in the transcript and protein content of the brain tissue. Recent studies indicate that alterations in non-coding RNAs (ncRNAs) signature underlie a proportion of this dysregulation. High throughput microarray investigations have demonstrated momentous alterations in the expression of long non-coding RNAs (lncRNA) and microRNAs (miRNAs) in the circulation or post-mortem brain tissues of patients with schizophrenia compared with control samples. While Gomafu, PINT, GAS5, TCONS_l2_00021339, IFNG-AS1, FAS-AS1, PVT1, and TUG1 are among down-regulated lncRNAs in schizophrenia, MEG3, THRIL, HOXA-AS2, Linc-ROR, SPRY4-IT1, UCA1, and MALAT1 have been up-regulated in these patients. Moreover, several miRNAs, such as miR-30e, miR-130b, hsa-miR-130b, miR-193a-3p, hsa-miR-193a-3p, hsa-miR-181b, hsa-miR-34a, hsa-miR-346, and hsa-miR-7 have been shown to be dysregulated in blood or brain samples of patients with schizophrenia. Dysregulation of these transcripts in schizophrenia not only provides insight into the pathogenic processes of this disorder, it also suggests these transcripts could serve as diagnostic markers for schizophrenia. In the present paper, we explore the changes in the expression of miRNAs and lncRNAs in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Section: Lncrna Profile In Peripheral Bloodmentioning

confidence: 98%

A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis

et al. 2021

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“…Furthermore, increasing numbers of studies have shown that the levels of lncRNA in breast cancer tissues are imbalanced, including molecules such as zinc finger E‐box binding homeobox 1 (ZEB1)‐AS1 17,18 . Th lncRNAs regulate a variety of cellular functions, disorders of which are often associated with human diseases, including cancer 19,20 …”

Section: Introductionmentioning

confidence: 99%

“…17,18 Th lncRNAs regulate a variety of cellular functions, disorders of which are often associated with human diseases, including cancer. 19,20 For example, TTN-AS1 has been identified as a novel lncRNA with previously published studies suggesting that TTN-AS1 is an oncogene in multiple cancers, for instance, hepatocellular carcinoma, cervical cancer, papillary thyroid cancer, and gastric cancer. 21,22 Cui et al 23 established that TTN-AS1 drives papillary thyroid carcinoma progression by regulation of the microRNA (miRNA)-153-3p/ZNRF2 axis and activation of the PI3K/Akt/mTOR pathway.…”

mentioning

confidence: 96%

lncRNA TTN‐AS1 facilitates proliferation, invasion, and epithelial‐mesenchymal transition of breast cancer cells by regulating miR‐139‐5p/ZEB1 axis

Fang

Huang

Jin

et al. 2020

J of Cellular Biochemistry

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Breast cancer is a common malignant tumor suffered predominantly by women worldwide, which results in serious levels of morbidity and mortality. To control the effects of the cancer, it is critically important to elucidate the pathophysiological processes by which it occurs and develops. Reports have demonstrated that long noncoding RNAs perform a critical role in the development and metastasis of cancers. The lncRNA TTN-AS1 is considered carcinogenic. Nevertheless, the importance and biological functions of TTN-AS1 in breast cancer require greater exploration. In the current paper, we observed that TTN-AS1 expression was significantly upregulated in breast cancer tissues/cells compared with those that are healthy. TTN-AS1 enhanced the proliferation, migration, invasion, and epithelialmesenchymal transformation of breast cancer cells. Furthermore, a direct target of TTN-AS1, miR-139-5p was negatively regulated. In addition, zinc finger E-box binding homeobox 1 (ZEB1) is an important nuclear transcription factor, the expression of which is increased in multiple tumors. Here, we also found that ZEB1 is a target of miR-139-5p, of which TTN-AS1 could regulate the expression through competition with miR-139-5p. That is, TTN-AS1 promoted proliferation and invasion of breast cancer cells by interaction with the miR-139-5p/ZEB1 axis. In conclusion, the present study aimed to illustrate the significance of TTN-AS1 in breast cancer metastasis and contribute to potentially innovative strategies for its treatment.

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“…Tan et al showed that Meg3 modulated AMPA Receptor expression in the primary cortical neuron surface ( 50 ). The expression of MEG3 in immune cells was reported to be differentially expressed in drug naïve psychosis patients compared to those treated with risperidone ( 51 ). A study using an Alzheimer's disease rat model reported that upregulation of MEG3 improved cognitive impairment and alleviates neuronal damage through inactivating the PI3K/Akt signaling pathway ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

Repeated Winning and Losing Experiences in Chronic Social Conflicts Are Linked to RNA Editing Pattern Difference

Kong

Ren

et al. 2022

Front. Psychiatry

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Winner-loser effects influence subsequent agonistic interactions between conspecifics. Previous winning experiences could strengthen future aggression and increase the chance of winning the next agonistic interaction, while previous losing experiences could have the opposite effect. Although the role of A-to-I RNA editing has been recently implicated in chronic social defeat stress and aggressive behavior, it remains to be further elucidated in chronic social conflicts in agonistic interactions, especially in the repeated aggression (winners) and repeated defeat (losers) resulted from these conflicts. In the current study, transcriptome-wide A-to-I RNA editing in the dorsal striatum was investigated in a mouse model of chronic social conflicts, and compared between mice repeatedly winning and losing daily agonistic interactions. Our analysis identified 622 A-to-I RNA editing sites in the mouse dorsal striatum, with 23 to be differentially edited in 22 genes, most of which had been previously associated with neurological, psychiatric, or immune disorders. Among these differential RNA editing (DRE) sites four missense variants were observed in neuroligin 2 (Nlgn2), Cdc42 guanine nucleotide exchange factor 9 (Arhgef9) BLCAP apoptosis inducing factor (Blcap), and cytoplasmic FMR1 interacting protein 2 (Cyfip2), as well as two noncoding RNA sites in small nucleolar RNA host gene 11 (Snhg11) and the maternally expressed 3 (Meg3) gene. Moreover, significant changes were observed in gene functions and pathways enriched by genes with A-to-I RNA editing in losers and especially winners compared to controls. Our results demonstrate that repeated winning and losing experiences in chronic social conflicts are linked to A-to-I RNA editing pattern difference, underlining its role in the molecular mechanism of agonistic interactions between conspecifics.

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Long Non-Coding RNAs Associated with Heterochromatin Function in Immune Cells in Psychosis

Cited by 14 publications

References 31 publications

A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis

A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis

lncRNA TTN‐AS1 facilitates proliferation, invasion, and epithelial‐mesenchymal transition of breast cancer cells by regulating miR‐139‐5p/ZEB1 axis

Repeated Winning and Losing Experiences in Chronic Social Conflicts Are Linked to RNA Editing Pattern Difference

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