Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer

Role of exosomal ncRNAs in traumatic brain injury

“…In recent years, studies have revealed new mechanisms of extracellular vesicle ncRNAs in intercellular communication networks [ 61 ]. Extracellular vesicle-derived ncRNAs have significant implications for the diagnosis, treatment, and prevention of complications following TBI ( Table 1 ) [ [62] , [63] , [64] , [65] , [66] ].…”

Circular RNA in cervical cancer: Fundamental mechanism and clinical potential

“…Furthermore, deeper inquiries into exosomes have unveiled their enrichment in lncRNAs originating from CC cells. This enrichment is underscored by the prominent expression of lncRNAs such as HOX antisense intergenic RNA (HOTAIR), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and maternally expressed 3 (MEG3) within CC-derived exosomes retrieved from cervicovaginal lavage samples [ 81 ]. Additionally, the specific enrichment of miR-221–3p has been noted within exosomes secreted by cervical squamous cell carcinoma cells.…”

The role of long non-coding RNAs and circular RNAs in cervical cancer: modulating miRNA function

“…C5orf66-AS1 lncRNA primarily resides in the cytoplasm, suggesting its modulation of CC cell functions through the competing endogenous RNA (ceRNA) mechanism (Begliarzade et al, 2023). Previous research has identified interactions between C5orf66-AS1 and various miRNAs, including miR-621, miR-637, miR-663b, miR-3184, miR-3187, miR-4449, miR-4706, and miR-5001, depicting its role as a sponge for these miRNAs.…”