Long Non-Coding RNAs as Molecular Biomarkers in Cholangiocarcinoma

Wu, Yanhua; Khizar, Hayat; Hu, Yufei; Yang, Jianfeng

doi:10.3389/fcell.2022.890605

Cited by 7 publications

(7 citation statements)

References 132 publications

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“…Moreover, long non-coding RNAs (lncRNAs) are characterized as non-coding RNAs whose transcripts are longer than 200 nucleotides lacking the ability to code for proteins but influencing tumorigenesis, which are also implicated in the molecular biomarkers of CCA ( 136 , 137 ). For instance, lncRNA PCAT1 was remarkably upregulated in both eCCA tissues and cell lines ( 109 ).…”

Section: Biomarkers Of Ecca Novel or Clinicalmentioning

confidence: 99%

An overview of extrahepatic cholangiocarcinoma: from here to where?

Yang

Zhang

2023

Front. Oncol.

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Extrahepatic cholangiocarcinoma (eCCA) contains perihilar cholangiocarcinoma and distal cholangiocarcinoma both of which can arise at any point of the biliary tree and originate from disparate anatomical sites. Generally, the incidence of eCCA is increasing globally. Though surgical resection is the principal treatment of choice for the early stages of eCCA, optimal survival remains restricted by the high risk of recurrence when most patients are present with unresectable disease or distant metastasis. Furthermore, both intra- and intertumoral heterogeneity make it laborious to determine molecularly targeted therapies. In this review, we mainly focused on current findings in the field of eCCA, mostly including epidemiology, genomic abnormalities, molecular pathogenesis, tumor microenvironment, and other details while a summary of the biological mechanisms driving eCCA may shed light on intricate tumorigenesis and feasible treatment strategies.

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Section: Biomarkers Of Ecca Novel or Clinicalmentioning

confidence: 99%

An overview of extrahepatic cholangiocarcinoma: from here to where?

Yang

Zhang

2023

Front. Oncol.

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“…Like miRNA, lncRNA also play dual role, as tumor suppressor role or oncogenic role. Some specific lncRNAs that have been studied in relation to Cholangiocarcinoma, such as Prostate cancer-associated transcript 1(PCAT1), Neighboring enhancer of FOXA2 (NEF), Metastasis-associated lung adenocarcinoma transcript 1(MALAT1), H19, Colon cancer-associated transcript 1 (CCAT1), and ZEB1 Antisense RNA 1(ZEB-AS1) ( Yang et al ., 2020 ; Wu et al ., 2022 ). Exostosin1 (EXT1): EXT1 is a gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis.…”

Section: Diagnosis and Management Of Cholangiocarcinomamentioning

confidence: 99%

Fish and Food-Fatale: Food-borne Trematode Opisthorchis viverrini and Cholangiocarcinoma

Tan,

Machrumnizar

2023

Helminthologia

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Summary Neglected Tropical Diseases (NTDs) are a group of communicable diseases with a long history with human beings. NTDs are the proxy of poverty since they affect those in low-income and extreme-poverty populations, as those populations lack access to proper health care, clean water, sanitary conditions, and hygiene. NTDs create losses for a nation that come from the health and the economic sectors as well since the costs of diagnosis, prevention, and treatment strain the national purse strings. One of the 20 different forms of NTDs on the list is food-borne trematodes, comprises of Fasciola, Paragonimus, Clonorchis, and Opisthorchis. Currently, it is estimated that food-borne trematodes can cause a devastating effect on mortality and morbidity. All of them are zoonotic, as humans become infected by ingestion of a second intermediate host, such as freshwater snails, fish, or water vegetables. Opisthorchis viverrini, one of the food-borne trematodes that can be found mostly in South East Asia regions, especially in the Mekong basin, is regarded as a group 1 carcinogen leading to cholangiocarcinoma (CCA). This study aims to present the updated review of Opisthorchis viverrini and CCA.

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“…As an important regulatory factor in the human genome, lncRNA regulates histone modification, DNA methylation, or chromosome reconstruction through epigenetic regulation, transcriptional or post-transcriptional regulation, and other mechanisms to silence or activate genes, and then dynamically control disease-related gene changes and some important biological processes [ 4 ]. The abnormal expression of lncRNA can participate in both tumor inhibition and carcinogenesis [ 5 ]. Currently, many lncRNAs have been confirmed to be abnormally expressed in various organ tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, many lncRNAs have been confirmed to be abnormally expressed in various organ tumors. They interact with microRNAs via multiple mechanisms regulating gene expression [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis

Du,

Hou,

Zhang

et al. 2023

Aging

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Background: LncRNA is an important regulatory factor in the human genome. We aim to explore the roles of LncFALEC and miR-20a-5p/SHOC2 axis on the proliferation, migration, and Fluorouracil (5-FU) resistance of cholangiocarcinoma (CCA). Methods: In this study, the expression of FALEC and miR-20a-5p in CCA tissues and cell lines (HuCCT1, QBC939, and Huh-28) was detected by RT-qPCR. The FALEC in 5-FU-resistant CCA cell lines (QBC939-R, Huh-28-R) was knocked down to evaluate its effects on cell proliferation, migration, invasion, and drug resistance. Results: Our analysis showed that compared with the adjacent non-tumor tissues, FALEC was significantly higher in the CCA tissues and even higher in the samples from 5-FU-resistant patients. Knockdown FALEC increased the sensitivity of 5-FU and decreased migration and invasion of CCA cells. Dual luciferase reporter confirmed that FALEC sponges miR-20a-5p and down-regulated its expression. Moreover, SHOC2 leucine-rich repeat scaffold protein (SHOC2) was the target gene of miR-20a-5p. We found overexpression of FALEC (FALEC-OE) increased resistance of CCA cells to 5-FU significantly, which might contribute to increased SHOC2 expression and activation of the ERK1/2 signaling pathway. Conclusions: In summary, our study revealed that down-regulation of FALEC could inhibit the proliferation, migration, and invasion of CCA cells in vitro by regulating the miR-20a-5p/SHOC2 axis and participating in 5-FU resistance by mediating the ERK1/2 signaling pathway.

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Long Non-Coding RNAs as Molecular Biomarkers in Cholangiocarcinoma

Cited by 7 publications

References 132 publications

An overview of extrahepatic cholangiocarcinoma: from here to where?

An overview of extrahepatic cholangiocarcinoma: from here to where?

Fish and Food-Fatale: Food-borne Trematode Opisthorchis viverrini and Cholangiocarcinoma

LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis

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