Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises

Lei, Cing Syuan; Kung, Hsing Jien; Shih, Jing Wen

doi:10.3390/ijms22094903

Cited by 10 publications

(5 citation statements)

References 163 publications

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“…Additionally, lncRNA BANCR in the OS model has been reported to function as an oncogene or tumor suppressor gene, which was often dysregulated in human cancers, including lung cancer [ 36 , 37 ]. Meanwhile, lncRNA MYOSLID in the DFS model was closely related to important biological processes and pathways that regulate cancer metastasis [ 38 – 40 ]. Notably, the coefficients of the two lncRNAs are the second biggest among the panels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Prognostic Value of Long Noncoding RNAs in Lung Squamous Cell Carcinoma

Zhang

et al. 2022

Journal of Oncology

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Lung squamous cell carcinoma (LUSC) is the most common type of lung cancer accounting for 40% to 51%. Long noncoding RNAs (lncRNAs) have been reported to play a significant role in the invasion, migration, and proliferation of lung cancer tissue cells. However, systematic identification of lncRNA signatures and evaluation of the prognostic value for LUSC are still an urgent problem. In this work, LUSC RNA-seq data were collected from TCGA database, and the limma R package was used to screen differentially expressed lncRNAs (DElncRNAs). In total, 216 DElncRNAs were identified between the LUSC and normal samples. lncRNAs associated with prognosis were calculated using univariate Cox regression analysis. The overall survival (OS) prognostic model containing 10 lncRNAs and the disease-free survival (DFS) prognostic model consisting of 11 lncRNAs were constructed using a machine learning-based algorithm, systematic LASSO-Cox regression analysis. We found that the survival rate of samples in the high-risk group was lower than that in the low-risk group. Results of ROC curves showed that both the OS and DFS risk score had better prognostic effects than the clinical characteristics, including age, stage, gender, and TNM. Two lncRNAs (LINC00519 and FAM83A-AS1) that were commonly identified as prognostic factors in both models could be further investigated for their clinical significance and therapeutic value. In conclusion, we constructed lncRNA prognostic models with considerable prognostic effect for both OS and DFS of LUSC.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Prognostic Value of Long Noncoding RNAs in Lung Squamous Cell Carcinoma

Zhang

et al. 2022

Journal of Oncology

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“…In particular, lncRNA and microRNA interference regulate OSCC metastasis via altering EMT (Han et al, 2020). Functional lncRNA differ from microRNA in that they can regulate gene expression at various levels, including chromatin modification, transcription, and posttranscriptional processes, which may impact EMT during cancer metastasis (Lei et al, 2021). The lncRNA expression profile in the human oral mucosa was first described by Gibb et al, (2011).…”

Section: The Effects Of Umbilical Cord Mesenchymal Stem Cells -Derive...mentioning

confidence: 99%

The Effects of Umbilical Cord Mesenchymal Stem Cells -Derived Exosomes in Oral Squamous Cell Carcinoma (In vitro Study)

Abdelwhab

El-Din

Sabry

et al. 2023

Asian Pac J Cancer Prev

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Objective: Mesenchymal stem cells (MSCs) derived exosomes offers several advantages as a cell-free therapeutic agents. In this study, Umbilical cord mesenchymal stem cells exosomes (UC-MSCs-exos) effects on oral squamous cell carcinoma (OSCC) cell line was evaluated. Methods: UC-MSCs-exos were isolated and co-cultured with OSCC cells and their impact on OSCC was explored by various tests. Comet assay and western blot for cleaved caspase-3 and immunocytochemistry for caspase-8 were used for apoptosis assessment. HO-1 and Nrf2 were used to determine antioxidant levels. Tumor necrosis factor-α and interleukin-6 were assessed as inflammatory biomarkers. HOX transcript antisense intergenic long noncoding RNA (HOTAIR) expression was also evaluated. Results: In a dose-dependent manner, UC-MSCs-exos reduced the levels of pro-inflammatory cytokines (IL-6 and TNF-α) and induced apoptosis of OSCC in vitro. Meanwhile, we found that UC-MSCs-exos downregulate HOTAIR. Conclusion: UC-MSCs-exos conferred a suppressive role on OSCC in vitro, highlighting a promising therapeutic role. However, the exact potentially involved molecules and molecular mechanisms need to be investigated in further studies.

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“…Specifically, by the activation of PI3K/AKT/mTOR signaling pathway, MALAT1 overexpression could lead to DDP resistance, whereas MALAT1 knockdown could effectively re-sensitize OSCC cells to DDP treatment, suggesting an instrumental role of MALAT1 in PI3K/AKT/mTOR signaling-associated DDP resistance development ( 214 ). Furthermore, PI3K/AKT/mTOR signaling is also known as a critical regulatory pathway of autophagy, a highly conserved catabolic process involving the lysosome-mediated degradation of intracytoplasmic components and participating in a variety of cellular biological activities ( 215 ). Autophagy may block or promote tumor survival, depending on the various tumor types and stages.…”

Section: Biogenesis and Function Of Lncrnas And Lncrnas-mediated Prog...mentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises

Cited by 10 publications

References 163 publications

Evaluation of the Prognostic Value of Long Noncoding RNAs in Lung Squamous Cell Carcinoma

Evaluation of the Prognostic Value of Long Noncoding RNAs in Lung Squamous Cell Carcinoma

The Effects of Umbilical Cord Mesenchymal Stem Cells -Derived Exosomes in Oral Squamous Cell Carcinoma (In vitro Study)

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

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